Results 1 to 10 of about 5,209 (116)

Nutrient supply affects the mRNA expression profile of the porcine skeletal muscle [PDF]

BMC Genomics, 2017
Background The genetic basis of muscle fat deposition in pigs is not well known. So far, we have only identified a limited number of genes involved in the absorption, transport, storage and catabolism of lipids.
Tainã Figueiredo Cardoso, Raquel Quintanilla, Joan Tibau, Marta Gil, Emilio Mármol-Sánchez, Olga González-Rodríguez, Rayner González-Prendes, Marcel Amills   +7 more
doaj   +6 more sources

Expression of circadian regulatory genes is dysregulated by increased cytokine production in mice subjected to concomitant intestinal injury and parenteral nutrition.

PLoS ONE, 2023
BackgroundWe have developed a mouse model of Parenteral Nutrition Associated Cholestasis (PNAC) in which combining intestinal inflammation and PN infusion results in cholestasis, hepatic macrophage activation, and transcriptional suppression of bile acid
Colin T Shearn, Aimee L Anderson, Michael W Devereaux, Karim C El Kasmi, David J Orlicky, Ronald J Sokol   +5 more
doaj   +3 more sources

MOLECULAR BASIS OF THE DEVELOPMENT OF INSULIN RESISTANCE IN OBESE ADOLESCENT AND ADULT MEN [PDF]

Biotechnologia Acta, 2022
The aim of this work was to study the association between the expression of glucose metabolism related genes and insulin resistance, which expression is changed in obese adolescents and adult men with and without insulin resistance, for better ...
Y. Viletska, D. Minchenko, O. Luzina, O. Ratushna   +3 more
doaj   +1 more source

Single-cell multi-omics analysis reveals dysfunctional Wnt signaling of spermatogonia in non-obstructive azoospermia

Frontiers in Endocrinology, 2023
BackgroundNon-obstructive azoospermia (NOA) is the most severe type that leads to 1% of male infertility. Wnt signaling governs normal sperm maturation.
Shengjie Zeng, Liuxun Chen, Xvdong Liu, Haibin Tang, Hao Wu, Chuan Liu   +5 more
doaj   +1 more source

Influence of DNA-Polymorphisms in Selected Circadian Clock Genes on Clock Gene Expression in Subjects from the General Population and Their Association with Sleep Duration

Medicina, 2022
Background and Objectives: Circadian rhythms have an important implication in numerous physiological and metabolic processes, including the sleep/wake cycle.
Rocío Barragán, José V. Sorlí, Oscar Coltell, Inmaculada Gonzalez-Monje, Rebeca Fernández-Carrión, Laura V. Villamil, Olga Portolés, Dolores Corella, Carolina Ortega-Azorín, Eva M. Asensio   +9 more
doaj   +1 more source

Circadian gene ARNTL initiates circGUCY1A2 transcription to suppress non-small cell lung cancer progression via miR-200c-3p/PTEN signaling

Journal of Experimental & Clinical Cancer Research, 2023
Background As a subclass of endogenous stable noncoding RNAs, circular RNAs are beginning to be appreciated for their potential as tumor therapeutics. However, the functions and mechanisms by which circRNAs exert protective functions in non-small cell ...
Deze Zhao, Yeping Dong, Minghao Duan, Dan He, Qun Xie, Wei Peng, Weifang Cui, Junjie Jiang, Yuanda Cheng, Heng Zhang, Faqing Tang, Chunfang Zhang, Yang Gao, Chaojun Duan   +13 more
doaj   +1 more source

Novel loci affecting iron homeostasis and their effects in individuals at risk for hemochromatosis [PDF]

, 2014
Variation in body iron is associated with or causes diseases, including anaemia and iron overload. Here, we analyse genetic association data on biochemical markers of iron status from 11 European-population studies, with replication in eight additional ...
Anderson, Denise, Benyamin, Beben, Broer, Linda, Esko, Tonu, Franke, Lude, Goegele, Martin, Haeldin, Jonas, Jolley, Jennifer, Kiemeney, Lambertus A., Kutalik, Zoltan, Luan, Jian'an, Meitinger, Thomas, Mihailov, Evelin, Milani, Lili, Peters, Annette, Podmore, Clara, Radhakrishnan, Aparna, Rendon, Augusto, Ried, Janina S., Sambrook, Jennifer, Sanna, Serena, Sweep, Fred C., Tanaka, Toshiko, Thiery, Joachim, Traglia, Michela, van der Meer, Peter, Vermeulen, Sita H., Waldenberger, Melanie, Wang, Fudi, Westra, Harm-Jan, Winkelmann, Juliane   +30 more
core   +11 more sources

Integrative analysis of circadian clock with prognostic and immunological biomarker identification in ovarian cancer

Frontiers in Molecular Biosciences, 2023
Objective: To identify circadian clock (CC)-related key genes with clinical significance, providing potential biomarkers and novel insights into the CC of ovarian cancer (OC).Methods: Based on the RNA-seq profiles of OC patients in The Cancer Genome ...
Lianfang Zhao, Yuqin Tang, Jiayan Yang, Fang Lin, Xiaofang Liu, Yongqiang Zhang, Jianhui Chen   +6 more
doaj   +1 more source

Photoperiodic Modulation of Circadian Clock and Reproductive Axis Gene Expression in the Pre-Pubertal European Sea Bass Brain [PDF]

, 2015
The acquisition of reproductive competence requires the activation of the brain-pituitary-gonad (BPG) axis, which in most vertebrates, including fishes, is initiated by changes in photoperiod.
A Felip, A Felip, A Servili, Adelino V. M. Canário, Ana Gomez, BH Miller, BL Smarr, CD Cohen, D González-Martínez, DJ Kennaway, E Saillant, F Espigares, F Prat, G Nabi, GL Taranger, H Volkoff, H Volkoff, HO de la Iglesia, I Begtashi, I Parhar, JH Choi, JM Gillespie, L Kovanen, L Rodrıguez, L Rodríguez, L Rodríguez, L Rodríguez, LM Beaver, M Tena-Sempere, Manuel Carrillo, MJ Bayarri, MJ Bayarri, ML Gottsch, N Zmora, Nicolas Cermakian, R Nishiguchi, R Rodríguez, RS Martins, RST Martins, Rute S. T. Martins, S Escobar, S Escobar, S Fessele, SE Klein, Silvia Zanuy, SL Harmer, T Kitahashi, T Werner, W Xia, WP Williams 3rd   +49 more
core   +18 more sources

Genome-wide study of association and interaction with maternal cytomegalovirus infection suggests new schizophrenia loci. [PDF]

, 2013
Genetic and environmental components as well as their interaction contribute to the risk of schizophrenia, making it highly relevant to include environmental factors in genetic studies of schizophrenia.
A D Børglum, A Hedemand, A Ludwig, A Miyashita, A Terracciano, A Uitterlinden, AC Need, AC Ravanpay, AD Skol, AG Cardno, AR Fisher, AR Morgan, AS Brown, AS Brown, AS Yap, B Janssens, B Nørgaard-Pedersen, B Xu, BH Shirts, BJ Fredette, BM Gumbiner, BM Neale, BM Neale, C B Pedersen, C Ciatto, C Wiuf, CB Pedersen, CE Murcray, CM Nievergelt, D Demontis, D Demontis, D M Hougaard, D Moreno-De-Luca, DB Boivin, GR Abecasis, H Le-Niculescu, H Stefansson, H Stefansson, HA Mansour, HA Mansour, HC So, I Sousa, J Grove, J Lasky-Su, J Majercak, J Novembre, J Pallesen, J Shi, J van Os, J Yang, JA Embil, JE Buizer-Voskamp, JJ Kim, K Wang, K Wulff, K Zhou, KH Baratz, KP Lesch, L Athanasiu, LN Moens, M Didriksen, M M Nöthen, M Mattheisen, M Nordentoft, M Nyegaard, M Nyegaard, M Rietschel, M Rietschel, M Scholz, M Takeichi, M Takeichi, M V Hollegaard, ML Rao, MS Keshavan, MV Hollegaard, N Cermakian, N Patterson, O Mors, O Mors, P B Mortensen, PA Holmans, PB Mortensen, PF Sullivan, R A Ophoff, R H Yolken, R Steinberg, RL Schelonka, S Cichon, S Purcell, S Ripke, S Steinberg, SA Riazuddin, SA Staras, SH Lee, SJ Sanders, SL Buka, SL Buka, SM Purcell, T Miyoshi, T Takeuchi, T Ørntoft, TJ Crow, TL Edwards, V Busby, V Soria, VR Sobrado, X Liang, Y Adachi, Y Li   +108 more
core   +7 more sources