Expression of circadian regulatory genes is dysregulated by increased cytokine production in mice subjected to concomitant intestinal injury and parenteral nutrition. [PDF]
PLoS ONE, 2023 BackgroundWe have developed a mouse model of Parenteral Nutrition Associated Cholestasis (PNAC) in which combining intestinal inflammation and PN infusion results in cholestasis, hepatic macrophage activation, and transcriptional suppression of bile acid
Colin T Shearn +5 more
doaj +5 more sources
Circadian gene ARNTL initiates circGUCY1A2 transcription to suppress non-small cell lung cancer progression via miR-200c-3p/PTEN signaling [PDF]
Journal of Experimental & Clinical Cancer Research, 2023 Background As a subclass of endogenous stable noncoding RNAs, circular RNAs are beginning to be appreciated for their potential as tumor therapeutics. However, the functions and mechanisms by which circRNAs exert protective functions in non-small cell ...
Deze Zhao +13 more
doaj +3 more sources
Bmal1 regulates inflammatory responses in macrophages by modulating enhancer RNA transcription
Scientific Reports, 2017 Bmal1 (encoded by Arntl gene) is a core circadian clock gene that regulates various genes involved in circadian rhythm. Although Bmal1 is expressed rhythmically in macrophages, the role of Bmal1 in the regulation of their cellular function remains ...
Yumiko Oishi +7 more
doaj +2 more sources
Monocyte/Macrophage-Specific Loss of ARNTL Suppresses Chronic Kidney Disease-Associated Cardiac Impairment. [PDF]
Int J Mol SciDefects in Aryl hydrocarbon receptor nuclear translocator-like 1 (ARNTL), a central component of the circadian clock mechanism, may promote or inhibit the induction of inflammation by monocytes/macrophages, with varying effects on different diseases ...
Yoshida Y +16 more
europepmc +2 more sources
d-Alanine, a Circadian Metabolite that Regulates Glucose Metabolism and Viral Infection. [PDF]
Chembiochemd‐Alanine is a circadian metabolite essential for life. Beyond exhibiting a pronounced circadian rhythm in its concentration within the body, d‐alanine regulates the circadian rhythm itself by influencing the circadian transcriptional network, thereby modulating related physiological processes such as glucose homeostasis.
Kimura T, Sakai S, Isaka Y.
europepmc +2 more sources
Role of the tendon circadian clock in tendinopathy and implications for therapeutics. [PDF]
Int J Exp PatholAbstract Tendinopathy or tendon overuse injury is a major clinical problem for individuals and has a significant socio‐economic cost. Its pathophysiology is not yet fully understood and involves multiple factors, including mechanical, cellular and molecular factors.
Møbjerg A +3 more
europepmc +2 more sources
MOLECULAR BASIS OF THE DEVELOPMENT OF INSULIN RESISTANCE IN OBESE ADOLESCENT AND ADULT MEN [PDF]
Biotechnologia Acta, 2022 The aim of this work was to study the association between the expression of glucose metabolism related genes and insulin resistance, which expression is changed in obese adolescents and adult men with and without insulin resistance, for better ...
Y. Viletska +3 more
doaj +1 more source
Frontiers in Endocrinology, 2023 BackgroundNon-obstructive azoospermia (NOA) is the most severe type that leads to 1% of male infertility. Wnt signaling governs normal sperm maturation.
Shengjie Zeng +5 more
doaj +1 more source
Clocks & Sleep, 2022 Circadian rhythms are self-sustained oscillators with a period of 24 h that is based on the output of transcriptional and post-translational feedback loops.
J. Ripperger +3 more
semanticscholar +1 more source
Targeting transcription factors in cancer — from undruggable to reality
Nature Reviews Cancer, 2019 John H Bushweller
exaly +2 more sources