Journal of Experimental & Clinical Cancer Research, 2023 Background As a subclass of endogenous stable noncoding RNAs, circular RNAs are beginning to be appreciated for their potential as tumor therapeutics. However, the functions and mechanisms by which circRNAs exert protective functions in non-small cell ...
Deze Zhao +13 more
doaj +2 more sources
PLoS ONE, 2023 BackgroundWe have developed a mouse model of Parenteral Nutrition Associated Cholestasis (PNAC) in which combining intestinal inflammation and PN infusion results in cholestasis, hepatic macrophage activation, and transcriptional suppression of bile acid
Colin T Shearn +5 more
doaj +4 more sources
Bmal1 regulates inflammatory responses in macrophages by modulating enhancer RNA transcription
Scientific Reports, 2017 Bmal1 (encoded by Arntl gene) is a core circadian clock gene that regulates various genes involved in circadian rhythm. Although Bmal1 is expressed rhythmically in macrophages, the role of Bmal1 in the regulation of their cellular function remains ...
Yumiko Oishi +7 more
doaj +2 more sources
Diurnal regulation of RNA polymerase III transcription is under the control of both the feeding–fasting response and the circadian clock [PDF]
Genome Research, 2017 RNA polymerase III (Pol III) synthesizes short noncoding RNAs, many of which are essential for translation. Accordingly, Pol III activity is tightly regulated with cell growth and proliferation by factors such as MYC, RB1, TRP53, and MAF1.
François Mange +5 more
semanticscholar +3 more sources
Nutrient supply affects the mRNA expression profile of the porcine skeletal muscle [PDF]
BMC Genomics, 2017 Background The genetic basis of muscle fat deposition in pigs is not well known. So far, we have only identified a limited number of genes involved in the absorption, transport, storage and catabolism of lipids.
Tainã Figueiredo Cardoso +7 more
doaj +6 more sources
ARNTL-mediated INO80-DHX15 axis reprograms the glycolytic metabolism and augments the progression of endometrial carcinoma. [PDF]
Cell Death DisImmune evasion is a major mechanism responsible for tumor cell survival and dissemination. This study aims to explore key molecules involved in immunosuppression and metastasis of endometrial carcinoma (EC).
Ye L, Jiang G, Sun Y, Li B.
europepmc +2 more sources
Deletion of Arntl, a component of the molecular clock, in adipocytes leads to cellular hypertrophy by increasing insulin sensitivity via FGF21. [PDF]
NPJ Biol Timing SleepBrain and muscle Arnt-like protein 1 (BMAL1), encoded by Aryl hydrocarbon receptor nuclear translocator like 1 (Arntl) gene, is a transcription factor that regulates the circadian rhythm of the expressions of several genes.
Ishii H, Kitaura S, Wada T, Shimba S.
europepmc +2 more sources
Parenteral nutrition results in peripheral ileal to hepatic circadian discordance in mice.
Am J Physiol Gastrointest Liver PhysiolBACKGROUND We have developed a mouse model of Parenteral Nutrition Associated Liver Disease in which PN infusion results in cholestatic liver injury.
Shearn CT +3 more
europepmc +2 more sources
MOLECULAR BASIS OF THE DEVELOPMENT OF INSULIN RESISTANCE IN OBESE ADOLESCENT AND ADULT MEN [PDF]
Biotechnologia Acta, 2022 The aim of this work was to study the association between the expression of glucose metabolism related genes and insulin resistance, which expression is changed in obese adolescents and adult men with and without insulin resistance, for better ...
Y. Viletska +3 more
doaj +1 more source
Frontiers in Endocrinology, 2023 BackgroundNon-obstructive azoospermia (NOA) is the most severe type that leads to 1% of male infertility. Wnt signaling governs normal sperm maturation.
Shengjie Zeng +5 more
doaj +1 more source