Results 131 to 140 of about 677,732 (163)

Circadian clock disruption impairs immune oscillation in chronic endogenous hypercortisolism: a multi-level analysis from a multicentre clinical trial. [PDF]

EBioMedicine
Hasenmajer V, Sbardella E, Sciarra F, Simeoli C, Pivonello C, Ceccato F, Pofi R, Minnetti M, Rizzo F, Ferrari D, Bonaventura I, Barbagallo F, Giannetta E, Alunni Fegatelli D, Conia S, Navigli R, Arnaldi G, Scaroni C, Pivonello R, Gianfrilli D, Venneri MA, Isidori AM.   +21 more
europepmc   +1 more source

Gene expression of Decompression Sickness-resistant rats through a miRnome/transcriptome crossed approach. [PDF]

Commun Biol
Dugrenot E, Guernec A, Orsat J, Guerrero F.   +3 more
europepmc   +1 more source

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The circadian clock gene ARNTL regulates the expression of CCR6 and Th17 related genes in human cells

Journal of Immunology, 2022
Previously we have shown that CCR6 expression uniquely defines a major branch of the Th effector/memory population that includes cells with both Th17 and Th17-associated phenotypes, therefore, studying the regulation of CCR6 will reveal molecular ...
S. Singh, Farhat Parween, Nithin Edara, Hongwei H Zhang, Paul J. Gardina, Francisco Otaizo-Carrasquero, T. Myers, J. Farber   +7 more
semanticscholar   +1 more source

Targeting bacterial transcription factors for infection control: opportunities and challenges

Transcription, 2023
The rising threat of antibiotic resistance in pathogenic bacteria emphasizes the need for new therapeutic strategies. This review focuses on bacterial transcription factors (TFs), which play crucial roles in bacterial pathogenesis.
Ahmed Al-Tohamy, A. Grove
semanticscholar   +1 more source

Transcription factors in the development and treatment of immune disorders

Transcription, 2023
Immune function is highly controlled at the transcriptional level by the binding of transcription factors (TFs) to promoter and enhancer elements. Several TF families play major roles in immune gene expression, including NF-κB, STAT, IRF, AP-1, NRs, and ...
Samantha D Patalano, Paula Fuxman Bass, J. F. Fuxman Bass   +2 more
semanticscholar   +1 more source

Relationship between AMPK and the transcriptional balance of clock-related genes in skeletal muscle.

American Journal of Physiology. Endocrinology and Metabolism, 2008
Circadian clocks coordinate physiological, behavioral, and biochemical events with predictable daily environmental changes by a self-sustained transcriptional feedback loop.
E. Vieira, Elisabeth C. Nilsson, A. Nerstedt, M. Ormestad, Y. C. Long, P. García-Rovés, J. Zierath, M. Mahlapuu   +7 more
semanticscholar   +1 more source

BMAL1 Links Bevacizumab Resistance in Colorectal Cancer to Circadian Rhythm and Heme Receptor REVERBA

Social Science Research Network, 2019
Heme sensor Nuclear Receptor Subfamily 1 Group D Member 1 (NR1D1/REVERBA) and its target gene Aryl Hydrocarbon Receptor Nuclear Translocator-Like (ARNTL/BMAL1) regulate circadian rhythm and angiogenesis.
E. Burgermeister, F. Battaglin, F. Eladly, Wen Wu, F. Herweck, N. Schulte, J. Betge, N. Härtel, Jakob Nikolas Kather, Cleo-Aron Weis, T. Gaiser, A. Marx, C. Weiss, R. Hofheinz, Ian S. Miller, F. Loupakis, H. Lenz, A. Byrne, M. Ebert   +18 more
semanticscholar   +1 more source

Parenteral nutrition results in peripheral ileal to hepatic circadian discordance in mice.

American Journal of Physiology - Gastrointestinal and Liver Physiology
BACKGROUND We have developed a mouse model of Parenteral Nutrition Associated Liver Disease in which PN infusion results in cholestatic liver injury.
C. Shearn, Aimee L Anderson, M. Devereaux, Ronald J. Sokol   +3 more
semanticscholar   +1 more source

Hypoxia-inducible transcription factors: architects of tumorigenesis and targets for anticancer drug discovery

Transcription
Hypoxia-inducible factors (HIFs) play a pivotal role as master regulators of tumor survival and growth, controlling a wide array of cellular processes in response to hypoxic stress.
Alexander McDermott, Ali Tavassoli
semanticscholar   +1 more source

Transcription factors of the NFAT family: regulation and function.

Annual Review of Immunology, 1997
As targets for the immunosuppressive drugs cyclosporin A and FK506, transcription factors of the NFAT (nuclear factor of activated T cells) family have been the focus of much attention. NFAT proteins, which are expressed in most immune-system cells, play
A. Rao, C. Luo, P. Hogan
semanticscholar   +1 more source