Results 11 to 20 of about 5,209 (116)

Melatonin-engineered MSCs-exosomes deliver USP4 to stabilise ARNTL and inhibit clock rhythmic ferroptosis for enhanced flap survival. [PDF]

Clin Transl Med
• Sleep restriction induces clock rhythmic ferroptosis, leading to skin flap necrosis. • MEXOs deliver USP4 to stabilise ARNTL, restoring circadian rhythm and inhibiting ferroptosis. • The METTL3/YTHDF1 m6A axis up‐regulates USP4 in melatonin‐preconditioned BMSCs.
Jiang X, Wang Y, Zhang X, Deng H, Fang L, Tafadzwa C, Yao J, Chen H, Ye A, Zhou K, Ling X, Xiao J.   +11 more
europepmc   +2 more sources

Myostatin Exhibits an Evolutionarily Conserved Circadian Pattern in Skeletal Muscles. [PDF]

J Cachexia Sarcopenia Muscle
ABSTRACT Introduction Myostatin (MSTN), a transforming growth factor‐beta (TGF‐β) superfamily member, is an evolutionarily conserved negative regulator of skeletal muscle mass. Loss of MSTN commonly promotes augmentation in skeletal muscle mass in all animal species examined.
Liu X, Song C, Xiong Y, Gu J, Wu L, Liu T, Chen X, Shu H, Dong Y, Shan T, Wang S, Zhu Y, Song T, Fu L, Lin Y, Liu C, Zheng R, Zhao X, Li H, Xu Y, Kuang S, Wang H, Guo B, Xu P, Jia Z.   +24 more
europepmc   +2 more sources

Associations of clock genes polymorphisms with soft tissue sarcoma susceptibility and prognosis [PDF]

, 2018
BACKGROUND: Dysfunction of the circadian clock and polymorphisms of some circadian genes have been linked to cancer development and progression. We investigated the relationship between circadian genes germline variation and susceptibility or prognosis ...
Benna, Clara, Del Fiore, Paolo, Mocellin, Simone, Rajendran, Senthilkumar, Rossi, Carlo Riccardo, Spiro, Giovanna, Tropea, Saveria   +6 more
core   +2 more sources

Predictive response-relevant clustering of expression data provides insights into disease processes [PDF]

, 2010
This article describes and illustrates a novel method of microarray data analysis that couples model-based clustering and binary classification to form clusters of ;response-relevant' genes; that is, genes that are informative when discriminating between
Abe, Amanda K. Sampson, Anna F. Dominiczak, Bach, Bae, Benjamini, Bennett, Bishop, Breitling, Bunger, Clark, de Snoo, Delyth Graham, Doi, Dudoit, Golub, Gore, Graham, Graham Young, Hanczar, Harris, Hoffbrand, Hubert, Huffman, Irizarry, Jeffs, John D. McClure, Kearney, Keith J. Harris, Lee, Lee, Lisa E. M. Hopcroft, Mark A. Girolami, Martin W. McBride, McBride, Mohri, Park, Stein, Tessa L. Holyoake, Tibshirani, Vinh, Weinberger, Woon, Ziino, Zuber   +44 more
core   +3 more sources

BMAL1 controls the diurnal rhythm and set point for electrical seizure threshold in mice

Frontiers in Systems Neuroscience, 2014
The epilepsies are a heterogeneous group of neurological diseases defined by the occurrence of unprovoked seizures which, in many cases, are correlated with diurnal rhythms.
Jason Robert Gerstner, Jason Robert Gerstner, George eSmith, George eSmith, Olivia eLenz, Isaac J Perron, Isaac J Perron, Russell J Buono, Thomas N Ferraro, Thomas N Ferraro, Thomas N Ferraro   +10 more
doaj   +1 more source

Metabolic syndrome influences cardiac gene expression pattern at the transcript level in male ZDF rats [PDF]

, 2013
Background: Metabolic syndrome (coexisting visceral obesity, dyslipidemia, hyperglycemia, and hypertension) is a prominent risk factor for cardiovascular morbidity and mortality, however, its effect on cardiac gene expression pattern is unclear ...
Csonka, Csaba, Csont, Tamás Bálint, Fekete, Veronika, Ferdinandy, Péter, Gyémánt, Nóra, Kocsis-Fodor, Gabriella, Pipis, Judit, Puskás, László, Szűcs, Gergő, Sárközy, Márta, Zvara, Ágnes   +10 more
core   +3 more sources

A bioinformatic analysis identifies circadian expression of splicing factors and time-dependent alternative splicing events in the HD-MY-Z cell line [PDF]

, 2019
The circadian clock regulates key cellular processes and its dysregulation is associated to several pathologies including cancer. Although the transcriptional regulation of gene expression by the clock machinery is well described, the role of the clock ...
Abreu, Mónica, Astaburuaga, Rosario, Basti, Alireza, Genov, Nikolai, Relógio, Angela   +4 more
core   +1 more source

Circadian Clock: A Regulator of Immunity in Autoimmune Diseases. [PDF]

Immun Inflamm Dis
This review explores the intricate connections between circadian clocks and immune responses in autoimmune diseases. We aim to open new avenues for therapeutic interventions, including chronotherapy and targeting clock genes, with the potential to improve treatment outcomes in autoimmune diseases.
Wu YJ, Zhang SY, Chen HY, He XR, Yang GR.   +4 more
europepmc   +2 more sources

Bmal1 regulates inflammatory responses in macrophages by modulating enhancer RNA transcription

Scientific Reports, 2017
Bmal1 (encoded by Arntl gene) is a core circadian clock gene that regulates various genes involved in circadian rhythm. Although Bmal1 is expressed rhythmically in macrophages, the role of Bmal1 in the regulation of their cellular function remains ...
Yumiko Oishi, Shinichiro Hayashi, Takayuki Isagawa, Motohiko Oshima, Atsushi Iwama, Shigeki Shimba, Hitoshi Okamura, Ichiro Manabe   +7 more
doaj   +1 more source

Diurnal regulation of RNA polymerase III transcription is under the control of both the feeding-fasting response and the circadian clock. [PDF]

, 2017
RNA polymerase III (Pol III) synthesizes short noncoding RNAs, many of which are essential for translation. Accordingly, Pol III activity is tightly regulated with cell growth and proliferation by factors such as MYC, RB1, TRP53, and MAF1.
Eugenia Migliavacca, François Mange, Frédéric Schütz, Ian M. Willis, Nouria Hernandez, null null, Viviane Praz   +6 more
core   +1 more source