Photoperiodic Modulation of Circadian Clock and Reproductive Axis Gene Expression in the Pre-Pubertal European Sea Bass Brain [PDF]
, 2015 The acquisition of reproductive competence requires the activation of the brain-pituitary-gonad (BPG) axis, which in most vertebrates, including fishes, is initiated by changes in photoperiod.
A Felip +49 more
core +19 more sources
BMAL1 controls the diurnal rhythm and set point for electrical seizure threshold in mice
Frontiers in Systems Neuroscience, 2014 The epilepsies are a heterogeneous group of neurological diseases defined by the occurrence of unprovoked seizures which, in many cases, are correlated with diurnal rhythms.
Jason Robert Gerstner +10 more
doaj +1 more source
A bioinformatic analysis identifies circadian expression of splicing factors and time-dependent alternative splicing events in the HD-MY-Z cell line [PDF]
, 2019 The circadian clock regulates key cellular processes and its dysregulation is associated to several pathologies including cancer. Although the transcriptional regulation of gene expression by the clock machinery is well described, the role of the clock ...
Abreu, Mónica +4 more
core +1 more source
Novel loci affecting iron homeostasis and their effects in individuals at risk for hemochromatosis. [PDF]
, 2014 Variation in body iron is associated with or causes diseases, including anaemia and iron overload. Here, we analyse genetic association data on biochemical markers of iron status from 11 European-population studies, with replication in eight additional ...
Amin, Najaf +70 more
core +12 more sources
Metabolic syndrome influences cardiac gene expression pattern at the transcript level in male ZDF rats [PDF]
, 2013 Background: Metabolic syndrome (coexisting visceral obesity, dyslipidemia, hyperglycemia, and hypertension) is a prominent risk factor for cardiovascular morbidity and mortality, however, its effect on cardiac gene expression pattern is unclear ...
Csonka, Csaba +10 more
core +3 more sources
Bmal1 regulates inflammatory responses in macrophages by modulating enhancer RNA transcription
Scientific Reports, 2017 Bmal1 (encoded by Arntl gene) is a core circadian clock gene that regulates various genes involved in circadian rhythm. Although Bmal1 is expressed rhythmically in macrophages, the role of Bmal1 in the regulation of their cellular function remains ...
Yumiko Oishi +7 more
doaj +1 more source
Diurnal regulation of RNA polymerase III transcription is under the control of both the feeding-fasting response and the circadian clock. [PDF]
, 2017 RNA polymerase III (Pol III) synthesizes short noncoding RNAs, many of which are essential for translation. Accordingly, Pol III activity is tightly regulated with cell growth and proliferation by factors such as MYC, RB1, TRP53, and MAF1.
Eugenia Migliavacca +6 more
core +1 more source
Npas4 is activated by melatonin, and drives the clock gene Cry1 in the ovine pars tuberalis [PDF]
, 2013 Seasonal mammalsintegrate changes in the duration of nocturnal melatonin secretion to drive annual physiologic cycles. Melatonin receptors within the proximal pituitary region, the pars tuberalis (PT), are essential in regulating seasonal neuroendocrine ...
Burt, Dw +8 more
core +1 more source
HMGCS2 is a key ketogenic enzyme potentially involved in type 1 diabetes with high cardiovascular risk. [PDF]
, 2017 Diabetes increases the risk of Cardio-vascular disease (CVD). CVD is more prevalent in type 2 diabetes (T2D) than type 1 diabetes (T1D), but the mortality risk is higher in T1D than in T2D. The pathophysiology of CVD in T1D is poorly defined.
Addya, Sankar +6 more
core +2 more sources
Genetic insights on sleep schedules: this time, it's PERsonal. [PDF]
, 2012 The study of circadian rhythms is emerging as a fruitful opportunity for understanding cellular mechanisms that govern human physiology and behavior, fueled by evidence directly linking sleep disorders to genetic mutations affecting circadian molecular ...
Chong, SY Christin +2 more
core +1 more source