Results 11 to 20 of about 619,220 (177)

Melatonin-engineered MSCs-exosomes deliver USP4 to stabilise ARNTL and inhibit clock rhythmic ferroptosis for enhanced flap survival. [PDF]

Clin Transl Med
• Sleep restriction induces clock rhythmic ferroptosis, leading to skin flap necrosis. • MEXOs deliver USP4 to stabilise ARNTL, restoring circadian rhythm and inhibiting ferroptosis. • The METTL3/YTHDF1 m6A axis up‐regulates USP4 in melatonin‐preconditioned BMSCs.
Jiang X, Wang Y, Zhang X, Deng H, Fang L, Tafadzwa C, Yao J, Chen H, Ye A, Zhou K, Ling X, Xiao J.   +11 more
europepmc   +2 more sources

Physical Interaction between Cyclin-Dependent Kinase 5 (CDK5) and Clock Factors Affects the Circadian Rhythmicity in Peripheral Oscillators

Clocks & Sleep, 2022
Circadian rhythms are self-sustained oscillators with a period of 24 h that is based on the output of transcriptional and post-translational feedback loops.
J. Ripperger, Rohit Chavan, U. Albrecht, Andrea Brenna   +3 more
semanticscholar   +1 more source

Influence of DNA-Polymorphisms in Selected Circadian Clock Genes on Clock Gene Expression in Subjects from the General Population and Their Association with Sleep Duration

Medicina, 2022
Background and Objectives: Circadian rhythms have an important implication in numerous physiological and metabolic processes, including the sleep/wake cycle.
Rocío Barragán, José V. Sorlí, Oscar Coltell, Inmaculada Gonzalez-Monje, Rebeca Fernández-Carrión, Laura V. Villamil, Olga Portolés, Dolores Corella, Carolina Ortega-Azorín, Eva M. Asensio   +9 more
doaj   +1 more source

Genome-wide study of association and interaction with maternal cytomegalovirus infection suggests new schizophrenia loci. [PDF]

, 2013
Genetic and environmental components as well as their interaction contribute to the risk of schizophrenia, making it highly relevant to include environmental factors in genetic studies of schizophrenia.
A D Børglum, A Hedemand, A Ludwig, A Miyashita, A Terracciano, A Uitterlinden, AC Need, AC Ravanpay, AD Skol, AG Cardno, AR Fisher, AR Morgan, AS Brown, AS Brown, AS Yap, B Janssens, B Nørgaard-Pedersen, B Xu, BH Shirts, BJ Fredette, BM Gumbiner, BM Neale, BM Neale, C B Pedersen, C Ciatto, C Wiuf, CB Pedersen, CE Murcray, CM Nievergelt, D Demontis, D Demontis, D M Hougaard, D Moreno-De-Luca, DB Boivin, GR Abecasis, H Le-Niculescu, H Stefansson, H Stefansson, HA Mansour, HA Mansour, HC So, I Sousa, J Grove, J Lasky-Su, J Majercak, J Novembre, J Pallesen, J Shi, J van Os, J Yang, JA Embil, JE Buizer-Voskamp, JJ Kim, K Wang, K Wulff, K Zhou, KH Baratz, KP Lesch, L Athanasiu, LN Moens, M Didriksen, M M Nöthen, M Mattheisen, M Nordentoft, M Nyegaard, M Nyegaard, M Rietschel, M Rietschel, M Scholz, M Takeichi, M Takeichi, M V Hollegaard, ML Rao, MS Keshavan, MV Hollegaard, N Cermakian, N Patterson, O Mors, O Mors, P B Mortensen, PA Holmans, PB Mortensen, PF Sullivan, R A Ophoff, R H Yolken, R Steinberg, RL Schelonka, S Cichon, S Purcell, S Ripke, S Steinberg, SA Riazuddin, SA Staras, SH Lee, SJ Sanders, SL Buka, SL Buka, SM Purcell, T Miyoshi, T Takeuchi, T Ørntoft, TJ Crow, TL Edwards, V Busby, V Soria, VR Sobrado, X Liang, Y Adachi, Y Li   +108 more
core   +7 more sources

Integrative analysis of circadian clock with prognostic and immunological biomarker identification in ovarian cancer

Frontiers in Molecular Biosciences, 2023
Objective: To identify circadian clock (CC)-related key genes with clinical significance, providing potential biomarkers and novel insights into the CC of ovarian cancer (OC).Methods: Based on the RNA-seq profiles of OC patients in The Cancer Genome ...
Lianfang Zhao, Yuqin Tang, Jiayan Yang, Fang Lin, Xiaofang Liu, Yongqiang Zhang, Jianhui Chen   +6 more
doaj   +1 more source

Photoperiodic Modulation of Circadian Clock and Reproductive Axis Gene Expression in the Pre-Pubertal European Sea Bass Brain [PDF]

, 2015
The acquisition of reproductive competence requires the activation of the brain-pituitary-gonad (BPG) axis, which in most vertebrates, including fishes, is initiated by changes in photoperiod.
A Felip, A Felip, A Servili, Adelino V. M. Canário, Ana Gomez, BH Miller, BL Smarr, CD Cohen, D González-Martínez, DJ Kennaway, E Saillant, F Espigares, F Prat, G Nabi, GL Taranger, H Volkoff, H Volkoff, HO de la Iglesia, I Begtashi, I Parhar, JH Choi, JM Gillespie, L Kovanen, L Rodrıguez, L Rodríguez, L Rodríguez, L Rodríguez, LM Beaver, M Tena-Sempere, Manuel Carrillo, MJ Bayarri, MJ Bayarri, ML Gottsch, N Zmora, Nicolas Cermakian, R Nishiguchi, R Rodríguez, RS Martins, RST Martins, Rute S. T. Martins, S Escobar, S Escobar, S Fessele, SE Klein, Silvia Zanuy, SL Harmer, T Kitahashi, T Werner, W Xia, WP Williams 3rd   +49 more
core   +18 more sources

Myostatin Exhibits an Evolutionarily Conserved Circadian Pattern in Skeletal Muscles. [PDF]

J Cachexia Sarcopenia Muscle
ABSTRACT Introduction Myostatin (MSTN), a transforming growth factor‐beta (TGF‐β) superfamily member, is an evolutionarily conserved negative regulator of skeletal muscle mass. Loss of MSTN commonly promotes augmentation in skeletal muscle mass in all animal species examined.
Liu X, Song C, Xiong Y, Gu J, Wu L, Liu T, Chen X, Shu H, Dong Y, Shan T, Wang S, Zhu Y, Song T, Fu L, Lin Y, Liu C, Zheng R, Zhao X, Li H, Xu Y, Kuang S, Wang H, Guo B, Xu P, Jia Z.   +24 more
europepmc   +2 more sources

Novel loci affecting iron homeostasis and their effects in individuals at risk for hemochromatosis [PDF]

, 2014
Variation in body iron is associated with or causes diseases, including anaemia and iron overload. Here, we analyse genetic association data on biochemical markers of iron status from 11 European-population studies, with replication in eight additional ...
Anderson, Denise, Benyamin, Beben, Broer, Linda, Esko, Tonu, Franke, Lude, Goegele, Martin, Haeldin, Jonas, Jolley, Jennifer, Kiemeney, Lambertus A., Kutalik, Zoltan, Luan, Jian'an, Meitinger, Thomas, Mihailov, Evelin, Milani, Lili, Peters, Annette, Podmore, Clara, Radhakrishnan, Aparna, Rendon, Augusto, Ried, Janina S., Sambrook, Jennifer, Sanna, Serena, Sweep, Fred C., Tanaka, Toshiko, Thiery, Joachim, Traglia, Michela, van der Meer, Peter, Vermeulen, Sita H., Waldenberger, Melanie, Wang, Fudi, Westra, Harm-Jan, Winkelmann, Juliane   +30 more
core   +11 more sources

Associations of clock genes polymorphisms with soft tissue sarcoma susceptibility and prognosis [PDF]

, 2018
BACKGROUND: Dysfunction of the circadian clock and polymorphisms of some circadian genes have been linked to cancer development and progression. We investigated the relationship between circadian genes germline variation and susceptibility or prognosis ...
Benna, Clara, Del Fiore, Paolo, Mocellin, Simone, Rajendran, Senthilkumar, Rossi, Carlo Riccardo, Spiro, Giovanna, Tropea, Saveria   +6 more
core   +2 more sources

BMAL1 controls the diurnal rhythm and set point for electrical seizure threshold in mice

Frontiers in Systems Neuroscience, 2014
The epilepsies are a heterogeneous group of neurological diseases defined by the occurrence of unprovoked seizures which, in many cases, are correlated with diurnal rhythms.
Jason Robert Gerstner, Jason Robert Gerstner, George eSmith, George eSmith, Olivia eLenz, Isaac J Perron, Isaac J Perron, Russell J Buono, Thomas N Ferraro, Thomas N Ferraro, Thomas N Ferraro   +10 more
doaj   +1 more source