Npas4 is activated by melatonin, and drives the clock gene Cry1 in the ovine pars tuberalis [PDF]
, 2013 Seasonal mammalsintegrate changes in the duration of nocturnal melatonin secretion to drive annual physiologic cycles. Melatonin receptors within the proximal pituitary region, the pars tuberalis (PT), are essential in regulating seasonal neuroendocrine ...
Burt, Dw +8 more
core +1 more source
Circadian control of interferon-sensitive gene expression in murine skin. [PDF]
, 2020 The circadian clock coordinates a variety of immune responses with signals from the external environment to promote survival. We investigated the potential reciprocal relationship between the circadian clock and skin inflammation.
Andersen, Bogi +9 more
core +2 more sources
Identification of novel HIV-1 dependency factors in primary CCR4+CCR6+Th17 cells via a genome-wide transcriptional approach [PDF]
, 2015 Additional file 2: Table S2. The complete list of genes down regulated in Th17 versus Th1 subsets are included and classified based on p-values
Annie Gosselin +14 more
core +6 more sources
Genetic insights on sleep schedules: this time, it's PERsonal. [PDF]
, 2012 The study of circadian rhythms is emerging as a fruitful opportunity for understanding cellular mechanisms that govern human physiology and behavior, fueled by evidence directly linking sleep disorders to genetic mutations affecting circadian molecular ...
Chong, SY Christin +2 more
core +1 more source
Sustained expression of microRNA-155 in hematopoietic stem cells causes a myeloproliferative disorder [PDF]
, 2008 Mammalian microRNAs are emerging as key regulators of the development and function of the immune system. Here, we report a strong but transient induction of miR-155 in mouse bone marrow after injection of bacterial lipopolysaccharide (LPS) correlated ...
Baltimore, David +7 more
core +3 more sources
HMGCS2 is a key ketogenic enzyme potentially involved in type 1 diabetes with high cardiovascular risk. [PDF]
, 2017 Diabetes increases the risk of Cardio-vascular disease (CVD). CVD is more prevalent in type 2 diabetes (T2D) than type 1 diabetes (T1D), but the mortality risk is higher in T1D than in T2D. The pathophysiology of CVD in T1D is poorly defined.
Addya, Sankar +6 more
core +2 more sources
HIV-1 selectively targets gut-homing CCR6+CD4+ T cells via mTOR-dependent mechanisms [PDF]
, 2017 Gut-associated lymphoid tissues are enriched in CCR6+ Th17-polarized CD4+ T cells that contribute to HIV-1 persistence during antiretroviral therapy (ART). This raises the need for Th17-targeted immunotherapies.
Ancuta, P +9 more
core +2 more sources
12-h clock regulation of genetic information flow by XBP1s [PDF]
, 2020 © The Author(s), 2020. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Pan, Y., Ballance, H., Meng, H., Gonzalez, N., Kim, S., Abdurehman, L., York, B., Chen, X., Schnytzer,
Abdurehman, Leymaan +14 more
core +1 more source
Ribosome profiling reveals the rhythmic liver translatome and circadian clock regulation by upstream open reading frames. [PDF]
, 2015 Mammalian gene expression displays widespread circadian oscillations. Rhythmic transcription underlies the core clock mechanism, but it cannot explain numerous observations made at the level of protein rhythmicity.
Arpat, A.B. +4 more
core +2 more sources
PRKCDBP (CAVIN3) and CRY2 associate with major depressive disorder [PDF]
, 2017 Peer ...
Donner, Kati +3 more
core +1 more source