Results 21 to 30 of about 677,732 (163)
Functional Characteristics of Gene Expression Motifs with Single and Dual Strategies of Regulation [PDF]
Biomed. Phys. Eng. Express, 2 , 025009(2016), 2016 Transcriptional regulation by transcription factors and post-transcriptional regulation by microRNAs constitute two major modes of regulation of gene expression. While gene expression motifs incorporating solely transcriptional regulation are well investigated, the dynamics of motifs with dual strategies of regulation, i.e., both transcriptional and ...
arxiv +1 more source
How the DNA sequence affects the Hill curve of transcriptional response [PDF]
Phys. Biol. 9 (2012) 056006, 2011 The Hill coefficient is often used as a direct measure of the cooperativity of binding processes. It is an essential tool for probing properties of reactions in many biochemical systems. Here we analyze existing experimental data and demonstrate that the Hill coefficient characterizing the binding of transcription factors to their cognate sites can in ...
arxiv +1 more source
Endocrinology, 2012 Coiled-coil domain containing 80 (Ccdc80) is a secreted protein highly enriched in mouse and human white adipose tissue (WAT) that plays an important role during adipocyte differentiation in vitro.
Frédéric Tremblay +12 more
semanticscholar +1 more source
Extending the dynamic range of transcription factor action by translational regulation [PDF]
Phys. Rev. E 93, 022404 (2016), 2015 A crucial step in the regulation of gene expression is binding of transcription factor (TF) proteins to regulatory sites along the DNA. But transcription factors act at nanomolar concentrations, and noise due to random arrival of these molecules at their binding sites can severely limit the precision of regulation.
arxiv +1 more source
Predictive response-relevant clustering of expression data provides insights into disease processes
Nucleic Acids Research, 2010 This article describes and illustrates a novel method of microarray data analysis that couples model-based clustering and binary classification to form clusters of `response-relevant' genes; that is, genes that are informative when discriminating between
L. Hopcroft +9 more
semanticscholar +1 more source
Pioneer Transcription Factors Initiating Gene Network Changes.
Annual Review of Genetics, 2020 Pioneer transcription factors have the intrinsic biochemical ability to scan partial DNA sequence motifs that are exposed on the surface of a nucleosome and thus access silent genes that are inaccessible to other transcription factors.
K. Zaret
semanticscholar +1 more source
A role for ATP-dependent chromatin remodeling in the hierarchical cooperativity between noninteracting transcription factors [PDF]
J. Theor. Biol. 287, 74-81 (2011), 2015 Chromatin remodeling machineries are abundant and diverse in eukaryotic cells. They have been involved in a variety of situations such as histone exchange and DNA repair, but their importance in gene expression remains unclear. Although the influence of nucleosome position on the regulation of gene expression is generally envisioned under the quasi ...
arxiv +1 more source
Control of noise in gene expression by transcriptional reinitiation [PDF]
, 2019 Gene expression is a random or noisy process. The process consists of several random events among which the reinitiation of transcription by RNAP is an important one. The RNAP molecules can bind the gene only after the promoter gets activated by transcription factors.
arxiv +1 more source
The role of master regulators in gene regulatory networks [PDF]
Papers in Physics 7, 070011 (2015), 2015 Gene regulatory networks present a wide variety of dynamical responses to intrinsic and extrinsic perturbations. Arguably, one of the most important of such coordinated responses is the one of amplification cascades, in which activation of a few key-responsive transcription factors (termed master regulators, MRs) lead to a large series of ...
arxiv +1 more source
Aging Cell, EarlyView.This study demonstrates that reducing the enzyme topoisomerase Top2 or its mammalian homolog TOP2B promotes longevity across multiple species, including yeast, worms, and mice. At the cellular/molecular level, TOP2B reduction mitigates the major cellular aging hallmarks such as epigenetic alterations, cell senescence, lysosomal biogenesis, and ...
Man Zhu +12 more
wiley +1 more source