Results 31 to 40 of about 619,220 (177)

Circadian Clock: A Regulator of Immunity in Autoimmune Diseases. [PDF]

Immun Inflamm Dis
This review explores the intricate connections between circadian clocks and immune responses in autoimmune diseases. We aim to open new avenues for therapeutic interventions, including chronotherapy and targeting clock genes, with the potential to improve treatment outcomes in autoimmune diseases.
Wu YJ, Zhang SY, Chen HY, He XR, Yang GR.   +4 more
europepmc   +2 more sources

HMGCS2 is a key ketogenic enzyme potentially involved in type 1 diabetes with high cardiovascular risk. [PDF]

, 2017
Diabetes increases the risk of Cardio-vascular disease (CVD). CVD is more prevalent in type 2 diabetes (T2D) than type 1 diabetes (T1D), but the mortality risk is higher in T1D than in T2D. The pathophysiology of CVD in T1D is poorly defined.
Addya, Sankar, Liu, Weijing, Rafiq, Khadija, Sarkar, Amrita, Shukla, Sanket Kumar, Sikder, Kunal, Wei, Yidong   +6 more
core   +2 more sources

12-h clock regulation of genetic information flow by XBP1s [PDF]

, 2020
© The Author(s), 2020. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Pan, Y., Ballance, H., Meng, H., Gonzalez, N., Kim, S., Abdurehman, L., York, B., Chen, X., Schnytzer,
Abdurehman, Leymaan, Ballance, Heather, Chen, Xi, Dacso, Clifford C., Gonzalez, Naomi, Kim, Sam-Moon, Levy, Oren, Liu, Silvia, McClung, Colleen A., Meng, Huan, O’Malley, Bert W., Pan, Yinghong, Schnytzer, Yisrael, York, Brian, Zhu, Bokai   +14 more
core   +1 more source

HIV-1 selectively targets gut-homing CCR6+CD4+ T cells via mTOR-dependent mechanisms [PDF]

, 2017
Gut-associated lymphoid tissues are enriched in CCR6+ Th17-polarized CD4+ T cells that contribute to HIV-1 persistence during antiretroviral therapy (ART). This raises the need for Th17-targeted immunotherapies.
Ancuta, P, Fassati, A, Gosselin, A, Goulet, J-P, Grandvaux, N, Hope, TJ, Monteiro, P, Planas, D, Routy, J-P, Zhang, Y   +9 more
core   +2 more sources

Circadian Entrainment Triggers Maturation of Human In Vitro Islets

, 2020
Stem-cell-derived tissues could transform disease research and therapy, yet most methods generate functionally immature products. We investigate how human pluripotent stem cells (hPSCs) differentiate into pancreatic islets in vitro by profiling DNA ...
Alvarez-Dominguez, J., Charlton, J., Donaghey, J., Helman, A., Kenty, J., Meissner, A., Melton, D., Rasouli, N., Straubhaar, J.   +8 more
core   +1 more source

Ribosome profiling reveals the rhythmic liver translatome and circadian clock regulation by upstream open reading frames. [PDF]

, 2015
Mammalian gene expression displays widespread circadian oscillations. Rhythmic transcription underlies the core clock mechanism, but it cannot explain numerous observations made at the level of protein rhythmicity.
Arpat, A.B., Castelo-Szekely, V., Gatfield, D., Janich, P., Lopes, M.   +4 more
core   +2 more sources

Predictive response-relevant clustering of expression data provides insights into disease processes

Nucleic Acids Research, 2010
This article describes and illustrates a novel method of microarray data analysis that couples model-based clustering and binary classification to form clusters of `response-relevant' genes; that is, genes that are informative when discriminating between
L. Hopcroft, M. McBride, K. Harris, Amanda K. Sampson, J. McClure, D. Graham, G. Young, T. Holyoake, M. Girolami, A. Dominiczak   +9 more
semanticscholar   +1 more source

PRKCDBP (CAVIN3) and CRY2 associate with major depressive disorder [PDF]

, 2017
Peer ...
Donner, Kati, Kaunisto, Mari, Kovanen, Leena, Partonen, Timo   +3 more
core   +1 more source

Resolving candidate genes of mouse skeletal muscle QTL via RNA-Seq and expression network analyses [PDF]

, 2012
Peer reviewedPublisher ...
Blizard, David A, Carroll, Andrew M, Derry, Jonathan M J, Lionikas, Arimantas, Meharg, Caroline, Ratkevicius, Aivaras, Vandenbergh, David J   +6 more
core   +2 more sources

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source