Results 31 to 40 of about 677,732 (163)

Midbrain Dopaminergic Neuron Development is Regulated by Two Molecularly Distinct Subtypes of Radial Glia Cells

bioRxiv
Understanding midbrain dopaminergic (mDA) neuron development is key to advancing cell replacement therapies for Parkinson’s disease (PD). Recent single-cell RNA-sequencing (scRNA-seq) studies have identified different subtypes of transient radial glia ...
E. S. Ásgrímsdóttir, Luca Fusar Bassini, Pia Rivetti di Val Cervo, Daniel Gyllborg, Clàudia Puigsasllosas Pastor, K. Lee, Christopher Grigsby, Saiful Islam, Peter Lönneberg, Carlos Villaescusa, C. Saltó, S. Linnarsson, Gioele La Manno, E. Toledo, Ernest Arenas   +14 more
semanticscholar   +1 more source

Circadian Gene BMAL1 Regulation of Cellular Senescence in Thyroid Aging

Aging Cell, EarlyView.
BMAL1 downregulation during aging reduces NFKBIA expression, accelerating thyroid cellular senescence and impairing hormone synthesis. Circadian rhythm disruption exacerbates thyroid functional decline, highlighting the BMAL1‐NFKBIA axis as a key mediator of aging‐related thyroid dysfunction and offering insights for stabilizing thyroid health in aging
Dandan Zong, Baihui Sun, Qiting Ye, Hongxin Cao, Haixia Guan   +4 more
wiley   +1 more source

Long‐term sub‐erythemal UVB exposure does not impact circadian rhythms in mice under standard and rotating shift light conditions

Photochemistry and Photobiology, EarlyView.
Circadian disruption is a potential carcinogen, but the impact of environmental carcinogens on circadian rhythms is unclear. Here we evaluated the impact of chronic UVB exposure with environmental‐ and genetic‐induced circadian disruption on mouse rhythmic locomotor activity and clock gene expression. Created in BioRender. Cone, S.
Adam J. Greer, Sean J. Cone, Rachel Bernstein, Elizabeth Schuetz, Narayani Prasad Kar, Bala S. C. Koritala, Shobhan Gaddameedhi   +6 more
wiley   +1 more source

Dynamics of gene expression and the regulatory inference problem [PDF]

, 2007
From the response to external stimuli to cell division and death, the dynamics of living cells is based on the expression of specific genes at specific times. The decision when to express a gene is implemented by the binding and unbinding of transcription factor molecules to regulatory DNA.
arxiv   +1 more source

A matter of time: Using dynamics and theory to uncover mechanisms of transcriptional bursting [PDF]

, 2020
Eukaryotic transcription generally occurs in bursts of activity lasting minutes to hours; however, state-of-the-art measurements have revealed that many of the molecular processes that underlie bursting, such as transcription factor binding to DNA, unfold on timescales of seconds.
arxiv   +1 more source

Post-transcriptional regulation across human tissues [PDF]

PLoS Comput Biol 13(5): e1005535 (2017), 2015
Transcriptional and post-transcriptional regulation shape tissue-type-specific proteomes, but their relative contributions remain contested. Estimates of the factors determining protein levels in human tissues do not distinguish between (i) the factors determining the variability between the abundances of different proteins, i.e., mean-level ...
arxiv   +1 more source

Single‐nucleus transcriptomics reveals subsets of degenerative myonuclei after rotator cuff tear‐induced muscle atrophy

Cell Proliferation, Volume 58, Issue 3, March 2025.
We performed single‐nucleus RNA‐seq to reveal the transcriptional heterogeneity in myofibers after rotator cuff tear (RCT). Gene signatures of all muscle tissue populations were identified after RCT to reveal the potential transitions of myofibers and other resident cells.
Ziying Sun, Xi Cheng, Zheng Wang, Chenfeng Qiao, Hong Qian, Tao Yuan, Zhongyang Lv, Wenshuang Sun, Hanwen Zhang, Yuan Liu, Zhihao Lu, Jintao Lin, Chengteng Lai, Yang Wang, Xiaojiang Yang, Xingyun Wang, Jia Meng, Nirong Bao   +17 more
wiley   +1 more source

Testosterone Modulation of Muscle Transcriptomic Profile During Lifestyle Therapy in Older Men with Obesity and Hypogonadism

Journal of Cachexia, Sarcopenia and Muscle, Volume 16, Issue 1, February 2025.
ABSTRACT Background Testosterone replacement therapy (TRT) added to lifestyle therapy can mitigate weight‐loss–induced reduction of muscle mass and bone mineral density (BMD) in older men with obesity and hypogonadism. Objective To investigate the molecular mechanisms underlying the attenuation of muscle and BMD loss in response to TRT during intensive
Viola Viola, Tagari Samanta, Maria Liza Duremdes Nava, Alessandra Celli, Reina Armamento‐Villareal, Ngoc Ho Lam Nguyen, Georgia Colleluori, Yoann Barnouin, Nicola Napoli, Clifford Qualls, Benny Abraham Kaipparettu, Dennis T. Villareal   +11 more
wiley   +1 more source

Integrative analysis of chromatin accessibility and transcriptome landscapes in the induction of peritoneal fibrosis by high glucose

Journal of Translational Medicine
Background Peritoneal fibrosis is the prevailing complication induced by prolonged exposure to high glucose in patients undergoing peritoneal dialysis.
Qiong Song, Pengbo Wang, Huan Wang, Meijing Pan, Xiujuan Li, Zhuan’e Yao, Wei Wang, Guangbo Tang, Sen Zhou   +8 more
doaj   +1 more source

Genome-wide discovery of modulators of transcriptional interactions in human B lymphocytes [PDF]

RECOMB'06 Proceedings, LNCS 3909, Springer, 2006, 2005
Transcriptional interactions in a cell are modulated by a variety of mechanisms that prevent their representation as pure pairwise interactions between a transcription factor and its target(s). These include, among others, transcription factor activation by phosphorylation and acetylation, formation of active complexes with one or more co-factors, and ...
arxiv   +1 more source