Results 41 to 50 of about 677,732 (163)
Discovery of Novel Pain Regulators Through Integration of Cross‐Species High‐Throughput Data
CNS Neuroscience &Therapeutics, Volume 31, Issue 2, February 2025.Cross‐species analysis was used to identify novel pain mediators based on human DRG expression profiles and RNA‐seq data from a mouse model of neuropathic pain injury. ABSTRACT Aims Chronic pain is an impeding condition that affects day‐to‐day life and poses a substantial economic burden, surpassing many other health conditions.
Ying Chen +9 more
wiley +1 more source
Patterns of subnet usage reveal distinct scales of regulation in the transcriptional regulatory network of Escherichia coli [PDF]
, 2010 The set of regulatory interactions between genes, mediated by transcription factors, forms a species' transcriptional regulatory network (TRN). By comparing this network with measured gene expression data one can identify functional properties of the TRN and gain general insight into transcriptional control.
arxiv +1 more source
The lower bound on the precision of transcriptional regulation [PDF]
Phys. Rev. E 90 (2014) 032708, 2014 The diffusive arrival of transcription factors at the promoter sites on the DNA sets a lower bound on how accurately a cell can regulate its protein levels. Using results from the literature on diffusion-influenced reactions, we derive an analytical expression for the lower bound on the precision of transcriptional regulation.
arxiv +1 more source
Nr4a transcription factors limit CAR T cell function in solid tumors
Nature, 2019 T cells expressing chimeric antigen receptors (CAR T cells) targeting human CD19 (hCD19) have shown clinical efficacy against B cell malignancies1,2.
Joyce Chen +8 more
semanticscholar +1 more source
Experimental Physiology, Volume 110, Issue 2, Page 261-276, 1 February 2025.Abstract Osteoporosis (OP) is a prevalent bone disease characterized by reduced bone density and quality, increasing fragility and fracture risk. Osteoclast (OC) activity and circadian rhythm play a role in the pathogenesis of OP. Melatonin is a circadian regulator that affects bone metabolism, but its molecular mechanism has not been studied in detail.
Jiewen Zhang +9 more
wiley +1 more source
Stochastic analysis of bistability in coherent mixed feedback loops combining transcriptional and post-transcriptional regulations [PDF]
, 2014 Mixed feedback loops combining transcriptional and post-transcriptional regulations are common in cellular regulatory networks. They consist of two genes, encoding a transcription factor and a small non-coding RNA (sRNA), which mutually regulate each other's expression.
arxiv +1 more source
The FASEB Journal, Volume 39, Issue 1, 15 January 2025.This study demonstrated the critical roles of C3/C3aR in developing AILI. In APAP‐treated mice, C3/C3aR signaling upregulated the expression and phosphorylation of transcription factors STATs and c‐Fos in hepatic Kupffer cells, which in turn increased PDPN expression, promoting platelet recruitment to the Kupffer cells via the interaction of PDPN and ...
Zhanli Xie +6 more
wiley +1 more source
Reliable scaling of Position Weight Matrices for binding strength comparisons between transcription factors [PDF]
arXiv, 2015 Scoring DNA sequences against Position Weight Matrices (PWMs) is a widely adopted method to identify putative transcription factor binding sites. While common bioinformatics tools produce scores that can reflect the binding strength between a specific transcription factor and the DNA, these scores are not directly comparable between different ...
arxiv
Resetting of the Human Circadian Melatonin Rhythm by Ambient Hypoxia
Journal of Pineal Research, Volume 77, Issue 1, January 2025.ABSTRACT Circadian clocks in the body drive daily cycles in physiology and behavior. A master clock in the brain maintains synchrony with the environmental day–night cycle and uses internal signals to keep clocks in other tissues aligned. Work in cell cultures uncovered cyclic changes in tissue oxygenation that may serve to reset and synchronize ...
Titiaan E. Post +11 more
wiley +1 more source
Proceedings of the National Academy of Sciences of the United States of America, 2019 Significance A recent exciting development in cancer therapy involves using a patient’s own immune system to attack cancers. The attack is carried out by CD8+ T cells that destroy the malignant cells; after infiltrating tumors, however, these cells ...
Hyungseok Seo +14 more
semanticscholar +1 more source