Results 41 to 50 of about 5,209 (116)

Identification of Melatonin-Regulated Genes in the Ovine Pituitary Pars Tuberalis, a Target Site for Seasonal Hormone Control [PDF]

, 2008
The pars tuberalis (PT) of the pituitary gland expresses a high density of melatonin (MEL) receptors and is believed to regulate seasonal physiology by decoding changes in nocturnal melatonin secretion.
Alison Downing, Ando, Andrew S. I. Loudon, Ashburner, Bae, Barrett, Bartness, Bechtold, Benoit Malpaux, Bockers, Bockers, Bockmann, Brahimi-Horn, Camon, Carr, Chemineau, Chen, Curlewis, Daphne Mouzaki, Dardente, Dave W. Burt, David Waddington, Draghici, Dupre, Fukuhara, Gerald A. Lincoln, Ghorbel, Graham, Grossmann, Hanon, Hazlerigg, Hazlerigg, Hazlerigg, Hogenesch, Hu, Hu, Johnston, Johnston, Johnston, Julian R. E. Davis, Kel, Kijas, Klosen, Ko, Lamolet, Lee, Lincoln, Lincoln, Lincoln, Lincoln, Malpaux, Merks, Messager, Michan, Morgan, Morgan, Mutoh, Nakao, Naya, Naya, Nilaweera, Oki, Poulin, Reick, Revollo, Richard Talbot, Roepke, Rutter, Samal, Sandrine M. Dupré, Schroeder, Segawa, Stehle, Stirland, Storey, Su, Tobler, Tournier, Wagner, Westfall, Williams, Wittkowski, Yang, Yokoyama   +83 more
core   +2 more sources

The Circadian Clock, the Immune System, and Viral Infections: The Intricate Relationship Between Biological Time and Host-Virus Interaction [PDF]

, 2020
Living beings spend their lives and carry out their daily activities interacting with environmental situations that present space-time variations and that involve contact with other life forms, which may behave as commensals or as invaders and/or ...
Carbone, Annalucia, Mazzoccoli, Gianluigi, Relógio, Angela, Vinciguerra, Manlio   +3 more
core   +1 more source

AMPK‐Dependent Epigenetic Regulation of Metabolism Mediates the Anti‐Cancer Action of Pterostilbene in Hepatocellular Carcinoma

Molecular Nutrition &Food Research, Volume 69, Issue 23, December 2025.
This study investigates the anti‐cancer effects of pterostilbene (PTS), a naturally occurring dietary phytoestrogen, in a rat model of hepatocellular carcinoma (HCC) induced by a choline‐deficient L‐amino acid‐defined (CDAA) diet. Supplementation with PTS significantly reduces liver steatosis and tumor formation.
Cayla Boycott, Megan Beetch, Katarzyna Lubecka‐Gajewska, Benjamin S. Ramsey, Sandra Torregrosa‐Allen, Bennett D. Elzey, Abigail Cox, Nadia Atallah Lanman, Aline de Conti, Min Li, Mario Ferruzzi, Igor Pogribny, Barbara Stefanska   +12 more
wiley   +1 more source

Integrative analysis of chromatin accessibility and transcriptome landscapes in the induction of peritoneal fibrosis by high glucose

Journal of Translational Medicine
Background Peritoneal fibrosis is the prevailing complication induced by prolonged exposure to high glucose in patients undergoing peritoneal dialysis.
Qiong Song, Pengbo Wang, Huan Wang, Meijing Pan, Xiujuan Li, Zhuan’e Yao, Wei Wang, Guangbo Tang, Sen Zhou   +8 more
doaj   +1 more source

Circadian rhythms and the light‐dark cycle interact to regulate amyloid‐beta plaque accumulation and tau phosphorylation in 5xFAD mice

Alzheimer's &Dementia, Volume 21, Issue 11, November 2025.
Abstract INTRODUCTION Circadian rhythm disruption is an early symptom of Alzheimer's disease (AD), though it remains unclear how the light‐dark (LD) cycle and the central circadian clock in the suprachiasmatic nucleus (SCN) influence AD pathobiology.
Melvin W. King, Sophie M. Jacob, Ashish Sharma, Jennifer H. Lawrence, Erik S. Musiek   +4 more
wiley   +1 more source

Core and region-enriched networks of behaviorally regulated genes and the singing genome [PDF]

, 2014
Songbirds represent an important model organism for elucidating molecular mechanisms that link genes with complex behaviors, in part because they have discrete vocal learning circuits that have parallels with those that mediate human speech.
Audet, Jean-Nicolas, Blatti, Charles A., Hartemink, Alexander J., Howard, Jason T., Jarvis, Erich D., Kellis, Manolis, Liu, Fang, Mukherjee, Sayan, Pfenning, Andreas R., Sinha, Saurabh, Wang, Rui, Ward, James M., West, Anne E., Whitney, Osceola   +13 more
core   +1 more source

Long‐term sub‐erythemal UVB exposure does not impact circadian rhythms in mice under standard and rotating shift light conditions

Photochemistry and Photobiology, Volume 101, Issue 6, Page 1429-1442, November/December 2025.
Circadian disruption is a potential carcinogen, but the impact of environmental carcinogens on circadian rhythms is unclear. Here we evaluated the impact of chronic UVB exposure with environmental‐ and genetic‐induced circadian disruption on mouse rhythmic locomotor activity and clock gene expression. Created in BioRender. Cone, S.
Adam J. Greer, Sean J. Cone, Rachel Bernstein, Elizabeth Schuetz, Narayani Prasad Kar, Bala S. C. Koritala, Shobhan Gaddameedhi   +6 more
wiley   +1 more source

Constructing a Model Using Clock‐Related lncRNAs for Predicting the Tumor Microenvironment of Gliomas

Brain and Behavior, Volume 15, Issue 10, October 2025.
Step 1: Identify hub clock‐related genes through differential expression analysis, univariate Cox analysis, and LASSO‐Cox regression; Step 2: Identify and screen hub clock‐related lncRNAs using correlation analysis and LASSO‐Cox regression; Step 3: Validate the expression differences of the selected lncRNAs in cell experiments using qPCR.
Mingjie Gong, Chengfa Sun, Zhenhua Shi, Junxiang Wang, Weiwei Zhai, Zhengquan Yu   +5 more
wiley   +1 more source

Circadian Rhythm Disruption Promotes Lung Tumorigenesis [PDF]

, 2018
Circadian rhythms are 24-hr oscillations that control a variety of biological processes in living systems, including two hallmarks of cancer, cell division and metabolism.
Bartlebaugh, Jordan M. E., Bauer, Matthew R., Bhutkar, Arjun, Davidson, Shawn M., Heimann, Megan Kristianne, Jacks, Tyler E., Papagiannakopoulos, Thales, Subbaraj, Lakshmipriya, Vander Heiden, Matthew G.   +8 more
core   +1 more source

Red Blood Cell‐Mediated Enhancement of Hematopoietic Stem Cell Functions via a Hes1‐Dependent Pathway

The FASEB Journal, Volume 39, Issue 17, 15 September 2025.
After chemotherapy, blood cell numbers initially decrease but later recover as hematopoietic progenitor cells increase. Following chemotherapy, RBC concentrations in bone marrow peaked at day 5, and direct contact between HSCs and RBCs increased. This contact induced elevated expression of Notch1 and Hes1 in HSCs. Hes1‐deficient HSCs and treatment with
Erika Yamashita, Soichiro Hashimoto, Hiroaki Abe, Takao Sudo, Daisuke Okuzaki, Toshiya Okawa, Masaru Ishii   +6 more
wiley   +1 more source