The effects of graded levels of calorie restriction : VI. Impact of short-term graded calorie restriction on transcriptomic responses of the hypothalamic hunger and circadian signaling pathways [PDF]
, 2016 Acknowledgements We would like to acknowledge the BSU staff for their invaluable help with caring for the animals. Funding The work was supported by the UK Biotechnology and Biological Sciences Research Council BBSRC (BB/G009953/1 and BB/J020028/1) to ...
Chen, Luonan +9 more
core +1 more source
The FASEB Journal, Volume 39, Issue 17, 15 September 2025.Tissue‐specific circadian clocks synchronize via diet, intestinal microbiota, and exercise. Time‐restricted feeding extends lifespan through synergistic action of molecular clocks and autophagy, establishing rhythmicity and harmony in hepatic proteasome activity.
Zhe Zhang, Bei‐bei Liu, Shu‐zhe Ding
wiley +1 more source
The Role of Ferroptosis in Women's Health and Diseases
MedComm, Volume 6, Issue 8, August 2025.At present, there are many common women's diseases, such as preeclampsia (PE), ovarian cancer, and cervical cancer, endangering women's health. These diseases all over the world are characterized by high morbidity and mortality. In the past decade, ferroptosis, a unique pattern of programmed cell death primarily driven by iron‐dependent phospholipid ...
Qiang Xu +5 more
wiley +1 more source
The effects of graded levels of calorie restriction : XI. Evaluation of the main hypotheses underpinning the life extension effects of CR using the hepatic transcriptome [PDF]
, 2017 We would like to acknowledge the BSU staff for their invaluable help with caring for the animals.Peer reviewedPublisher ...
Chen, Luonan +10 more
core +1 more source
Circadian Gene BMAL1 Regulation of Cellular Senescence in Thyroid Aging
Aging Cell, Volume 24, Issue 8, August 2025.BMAL1 downregulation during aging reduces NFKBIA expression, accelerating thyroid cellular senescence and impairing hormone synthesis. Circadian rhythm disruption exacerbates thyroid functional decline, highlighting the BMAL1‐NFKBIA axis as a key mediator of aging‐related thyroid dysfunction and offering insights for stabilizing thyroid health in aging
Dandan Zong +4 more
wiley +1 more source
Biology of the Cell, Volume 117, Issue 7, July 2025.Homeobox genes associated with the circadian rhythm and the development of specific tissues, playing crucial roles in regulating cellular differentiation and the formation of structures during embryonic development. ABSTRACT As master regulators of embryonic development, regulating homeobox genes is fundamental for developmental biology.
Joice de Faria Poloni +1 more
wiley +1 more source
Polymorphisms in the circadian expressed genes PER3 and ARNTL2 are associated with diurnal preference and GNβ3 with sleep measures [PDF]
, 2014 Sleep and circadian rhythms are intrinsically linked, with several sleep traits, including sleep timing and duration, influenced by both sleep homeostasis and the circadian phase.
Archer, Simon N +6 more
core +2 more sources
Aging Cell, Volume 24, Issue 6, June 2025.This study demonstrates that reducing the enzyme topoisomerase Top2 or its mammalian homolog TOP2B promotes longevity across multiple species, including yeast, worms, and mice. At the cellular/molecular level, TOP2B reduction mitigates the major cellular aging hallmarks such as epigenetic alterations, cell senescence, lysosomal biogenesis, and ...
Man Zhu +12 more
wiley +1 more source
The Emerging Role of Epigenetic Modifiers in Repair of DNA Damage Associated with Chronic Inflammatory Diseases [PDF]
, 2017 At sites of chronic inflammation epithelial cells are exposed to high levels of reactive oxygen species (ROS), which can contribute to the initiation and development of many different human cancers.
Ding, Ning +2 more
core +1 more source
Circadian Rhythm Abnormalities in Parkinson's Disease from Humans to Flies and Back [PDF]
, 2018 Clinical and research studies have suggested a link between Parkinson\u2019s disease (PD) and alterations in the circadian clock. Drosophila melanogaster may represent a useful model to study the relationship between the circadian clock and PD.
Bisaglia, Marco +3 more
core +1 more source