Results 51 to 60 of about 677,732 (163)

Genomic responses to climatic challenges in beef cattle: A review

Animal Genetics, Volume 55, Issue 6, Page 854-870, December 2024.
Abstract Climate change is a major concern for the near future and for livestock breeding. Cattle breeding, due to its greenhouse gas emissions, is one of the most implicated industries. Consequently, the main future goals are to breed animals resilient to climate change, with the aim of lowering the livestock impact on the environment and selecting ...
Daniele Colombi, Francesco Perini, Stefano Bettini, Salvatore Mastrangelo, Fabio Abeni, Giuseppe Conte, Donata Marletta, Martino Cassandro, Umberto Bernabucci, Roberta Ciampolini, Emiliano Lasagna   +10 more
wiley   +1 more source

Fundamental Dynamic Units: Feedforward Networks and Adjustable Gates [PDF]

arXiv, 2009
The activation/repression of a given gene is typically regulated by multiple transcription factors (TFs) that bind at the gene regulatory region and recruit RNA polymerase (RNAP). The interactions between the promoter region and TFs and between different TFs specify the dynamic responses of the gene under different physiological conditions. By choosing
arxiv  

Non-equilibrium dynamics of gene expression and the Jarzynski equality [PDF]

, 2007
In order to express specific genes at the right time, the transcription of genes is regulated by the presence and absence of transcription factor molecules. With transcription factor concentrations undergoing constant changes, gene transcription takes place out of equilibrium.
arxiv   +1 more source

AnimalTFDB 3.0: a comprehensive resource for annotation and prediction of animal transcription factors

Nucleic Acids Res., 2018
The Animal Transcription Factor DataBase (AnimalTFDB) is a resource aimed to provide the most comprehensive and accurate information for animal transcription factors (TFs) and cofactors.
Hui Hu, Ya-Ru Miao, Longhao Jia, Qingyang Yu, Qiong Zhang, An-Yuan Guo   +5 more
semanticscholar   +1 more source

Disruption of day‐to‐night changes in circadian gene expression with chronic tendinopathy

The Journal of Physiology, Volume 602, Issue 23, Page 6509-6524, 1 December 2024.
Abstract figure legend The primary goal of this study was to establish whether human tendon tissue is a circadian clock. Limited by obtaining only two patellar biopsies from each subject, we designed a study taking the biopsies 12 h apart, once in the day and once in the night, and analysed the gene expression by RNA sequencing.
Ching‐Yan Chloé Yeung, René B. Svensson, Kateryna Yurchenko, Nikolaj M. Malmgaard‐Clausen, Ida Tryggedsson, Marius Lendal, Anja Jokipii‐Utzon, Jens L. Olesen, Yinhui Lu, Karl E. Kadler, Peter Schjerling, Michael Kjær   +11 more
wiley   +1 more source

Deciphering the dynamic code: DNA recognition by transcription factors in the ever-changing genome

Transcription
Transcription factors (TFs) intricately navigate the vast genomic landscape to locate and bind specific DNA sequences for the regulation of gene expression programs.
Yumi Minyi Yao, Irina Miodownik, Michael P O'Hagan, Muhammad Jbara, Ariel Afek   +4 more
semanticscholar   +1 more source

PlantTFDB 4.0: toward a central hub for transcription factors and regulatory interactions in plants

Nucleic Acids Res., 2016
With the goal of providing a comprehensive, high-quality resource for both plant transcription factors (TFs) and their regulatory interactions with target genes, we upgraded plant TF database PlantTFDB to version 4.0 (http://planttfdb.cbi.pku.edu.cn ...
Jinpu Jin, Feng Tian, Dechang Yang, Yuqi Meng, Lei Kong, Jingchu Luo, Ge Gao   +6 more
semanticscholar   +1 more source

Serum iron and transferrin saturation variation are circadian regulated and linked to the harmonic circadian oscillations of erythropoiesis and hepatic Tfrc expression in mice

American Journal of Hematology, Volume 99, Issue 11, Page 2075-2083, November 2024.
Abstract Serum iron has long been thought to exhibit diurnal variation and is subsequently considered an unreliable biomarker of systemic iron status. Circadian regulation (endogenous ~24‐h periodic oscillation of a biologic function) governs many critical physiologic processes.
Cavan Bennett, Anne Pettikiriarachchi, Alistair R. D. McLean, Rebecca Harding, Marnie E. Blewitt, Cyril Seillet, Sant‐Rayn Pasricha   +6 more
wiley   +1 more source

Unsupervised learning of transcriptional regulatory networks via latent tree graphical models [PDF]

arXiv, 2016
Gene expression is a readily-observed quantification of transcriptional activity and cellular state that enables the recovery of the relationships between regulators and their target genes. Reconstructing transcriptional regulatory networks from gene expression data is a problem that has attracted much attention, but previous work often makes the ...
arxiv  

The circadian rhythm: A key variable in aging?

Aging Cell, Volume 23, Issue 11, November 2024.
In this study, general age‐related transcriptional trajectories in seven organs were investigated over the lifespan of mice. Since both sexes and two strains were used equally, biases in this regard are diminished. Twenty replicas per time provide a deeper insight than usual.
Patrick R. Winterhalter, Adrian‐Iustin Georgevici, Nitin J. Gharpure, Gábor Szabó, Andreas Simm   +4 more
wiley   +1 more source