Results 51 to 60 of about 619,220 (177)

Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities.

Molecules and Cells, 2010
Genome-scale studies have revealed extensive, cell type-specific colocalization of transcription factors, but the mechanisms underlying this phenomenon remain poorly understood.
S. Heinz, C. Benner, N. Spann, E. Bertolino, Yin C Lin, P. Laslo, Jason X. Cheng, C. Murre, Harinder Singh, C. Glass   +9 more
semanticscholar   +1 more source

Identification of Melatonin-Regulated Genes in the Ovine Pituitary Pars Tuberalis, a Target Site for Seasonal Hormone Control [PDF]

, 2008
The pars tuberalis (PT) of the pituitary gland expresses a high density of melatonin (MEL) receptors and is believed to regulate seasonal physiology by decoding changes in nocturnal melatonin secretion.
Alison Downing, Ando, Andrew S. I. Loudon, Ashburner, Bae, Barrett, Bartness, Bechtold, Benoit Malpaux, Bockers, Bockers, Bockmann, Brahimi-Horn, Camon, Carr, Chemineau, Chen, Curlewis, Daphne Mouzaki, Dardente, Dave W. Burt, David Waddington, Draghici, Dupre, Fukuhara, Gerald A. Lincoln, Ghorbel, Graham, Grossmann, Hanon, Hazlerigg, Hazlerigg, Hazlerigg, Hogenesch, Hu, Hu, Johnston, Johnston, Johnston, Julian R. E. Davis, Kel, Kijas, Klosen, Ko, Lamolet, Lee, Lincoln, Lincoln, Lincoln, Lincoln, Malpaux, Merks, Messager, Michan, Morgan, Morgan, Mutoh, Nakao, Naya, Naya, Nilaweera, Oki, Poulin, Reick, Revollo, Richard Talbot, Roepke, Rutter, Samal, Sandrine M. Dupré, Schroeder, Segawa, Stehle, Stirland, Storey, Su, Tobler, Tournier, Wagner, Westfall, Williams, Wittkowski, Yang, Yokoyama   +83 more
core   +2 more sources

Fresh insights into the light‐induced pineal gland circadian rhythm transmission mechanism derived from mRNA and miRNA profiling

Animal Research and One Health, Volume 4, Issue 1, Page 36-54, February 2026.
Mechanisms of light in regulating the chick pineal clock. Abstract The circadian clock significantly impacts animal health and productivity, with light playing a crucial role in regulating circadian rhythms. However, the mechanisms behind light‐induced circadian transmission remain unclear, particularly in light‐sensitive avian species.
Yunlei Li, Yanyan Sun, Jingwei Yuan, Xiangchen Li, Lei Shi, Adamu Mani Isa, Yuanmei Wang, Pingzhuang Ge, Yunhe Zong, Panlin Wang, Jilan Chen   +10 more
wiley   +1 more source

Integrative Omics Reveal Female‐Specific Benefits of p16+ Cell Clearance in Aging Mice

Advanced Science, Volume 13, Issue 3, 14 January 2026.
Aging causes accumulation of p16⁺ senescent cells that promote inflammation and dysfunction. Multi‐omics analyses reveal striking sex differences in senescent cell burden and clearance: females accumulate more p16⁺ cells, especially in the liver, and their removal rejuvenates molecular and functional profiles.
Yao Lin, Boshi Wang, Mengling Huang, Justina C. Wolters, Marco Demaria   +4 more
wiley   +1 more source

Integrative analysis of chromatin accessibility and transcriptome landscapes in the induction of peritoneal fibrosis by high glucose

Journal of Translational Medicine
Background Peritoneal fibrosis is the prevailing complication induced by prolonged exposure to high glucose in patients undergoing peritoneal dialysis.
Qiong Song, Pengbo Wang, Huan Wang, Meijing Pan, Xiujuan Li, Zhuan’e Yao, Wei Wang, Guangbo Tang, Sen Zhou   +8 more
doaj   +1 more source

Circadian Rhythm Disruption Promotes Lung Tumorigenesis [PDF]

, 2018
Circadian rhythms are 24-hr oscillations that control a variety of biological processes in living systems, including two hallmarks of cancer, cell division and metabolism.
Bartlebaugh, Jordan M. E., Bauer, Matthew R., Bhutkar, Arjun, Davidson, Shawn M., Heimann, Megan Kristianne, Jacks, Tyler E., Papagiannakopoulos, Thales, Subbaraj, Lakshmipriya, Vander Heiden, Matthew G.   +8 more
core   +1 more source

Core and region-enriched networks of behaviorally regulated genes and the singing genome [PDF]

, 2014
Songbirds represent an important model organism for elucidating molecular mechanisms that link genes with complex behaviors, in part because they have discrete vocal learning circuits that have parallels with those that mediate human speech.
Audet, Jean-Nicolas, Blatti, Charles A., Hartemink, Alexander J., Howard, Jason T., Jarvis, Erich D., Kellis, Manolis, Liu, Fang, Mukherjee, Sayan, Pfenning, Andreas R., Sinha, Saurabh, Wang, Rui, Ward, James M., West, Anne E., Whitney, Osceola   +13 more
core   +1 more source

The Human Transcription Factors.

Cell, 2018
Samuel A. Lambert,1,9 Arttu Jolma,2,9 Laura F. Campitelli,1,9 Pratyush K. Das,3 Yimeng Yin,4 Mihai Albu,2 Xiaoting Chen,5 Jussi Taipale,3,4,6,* Timothy R. Hughes,1,2,* and Matthew T.
Samuel A. Lambert, A. Jolma, L. Campitelli, P. Das, Yimeng Yin, Mihai Albu, Xiaoting Chen, J. Taipale, T. Hughes, M. Weirauch   +9 more
semanticscholar   +1 more source

The effects of graded levels of calorie restriction : VI. Impact of short-term graded calorie restriction on transcriptomic responses of the hypothalamic hunger and circadian signaling pathways [PDF]

, 2016
Acknowledgements We would like to acknowledge the BSU staff for their invaluable help with caring for the animals. Funding The work was supported by the UK Biotechnology and Biological Sciences Research Council BBSRC (BB/G009953/1 and BB/J020028/1) to ...
Chen, Luonan, Derous, Davina, Douglas, Alex, Green, Cara L., Han, Jing-Dong J., Lusseau, David, Mitchell, Sharon E., Promislow, Daniel E. L., Speakman, John R., Wang, Yingchun   +9 more
core   +1 more source

AMPK‐Dependent Epigenetic Regulation of Metabolism Mediates the Anti‐Cancer Action of Pterostilbene in Hepatocellular Carcinoma

Molecular Nutrition &Food Research, Volume 69, Issue 23, December 2025.
This study investigates the anti‐cancer effects of pterostilbene (PTS), a naturally occurring dietary phytoestrogen, in a rat model of hepatocellular carcinoma (HCC) induced by a choline‐deficient L‐amino acid‐defined (CDAA) diet. Supplementation with PTS significantly reduces liver steatosis and tumor formation.
Cayla Boycott, Megan Beetch, Katarzyna Lubecka‐Gajewska, Benjamin S. Ramsey, Sandra Torregrosa‐Allen, Bennett D. Elzey, Abigail Cox, Nadia Atallah Lanman, Aline de Conti, Min Li, Mario Ferruzzi, Igor Pogribny, Barbara Stefanska   +12 more
wiley   +1 more source