Results 61 to 70 of about 619,220 (177)

Circadian rhythms and the light‐dark cycle interact to regulate amyloid‐beta plaque accumulation and tau phosphorylation in 5xFAD mice

Alzheimer's &Dementia, Volume 21, Issue 11, November 2025.
Abstract INTRODUCTION Circadian rhythm disruption is an early symptom of Alzheimer's disease (AD), though it remains unclear how the light‐dark (LD) cycle and the central circadian clock in the suprachiasmatic nucleus (SCN) influence AD pathobiology.
Melvin W. King, Sophie M. Jacob, Ashish Sharma, Jennifer H. Lawrence, Erik S. Musiek   +4 more
wiley   +1 more source

Transcription Factors Activate Genes through the Phase-Separation Capacity of Their Activation Domains.

Cell, 2018
Gene expression is controlled by transcription factors (TFs) that consist of DNA-binding domains (DBDs) and activation domains (ADs). The DBDs have been well characterized, but little is known about the mechanisms by which ADs effect gene activation ...
Ann Boija, Isaac A. Klein, Benjamin R. Sabari, Alessandra Dall’Agnese, Eliot L. Coffey, A. V. Zamudio, Charles H. Li, Krishna Shrinivas, John C. Manteiga, N. Hannett, B. Abraham, Lena K. Afeyan, Y. Guo, Jenna K. Rimel, Charli B. Fant, Jurian Schuijers, Tong Ihn Lee, D. Taatjes, R. Young   +18 more
semanticscholar   +1 more source

Long‐term sub‐erythemal UVB exposure does not impact circadian rhythms in mice under standard and rotating shift light conditions

Photochemistry and Photobiology, Volume 101, Issue 6, Page 1429-1442, November/December 2025.
Circadian disruption is a potential carcinogen, but the impact of environmental carcinogens on circadian rhythms is unclear. Here we evaluated the impact of chronic UVB exposure with environmental‐ and genetic‐induced circadian disruption on mouse rhythmic locomotor activity and clock gene expression. Created in BioRender. Cone, S.
Adam J. Greer, Sean J. Cone, Rachel Bernstein, Elizabeth Schuetz, Narayani Prasad Kar, Bala S. C. Koritala, Shobhan Gaddameedhi   +6 more
wiley   +1 more source

Nr4a transcription factors limit CAR T cell function in solid tumors

Nature, 2019
T cells expressing chimeric antigen receptors (CAR T cells) targeting human CD19 (hCD19) have shown clinical efficacy against B cell malignancies1,2.
Joyce Chen, Isaac F. López-Moyado, Hyungseok Seo, C. Lio, Laura J. Hempleman, T. Sekiya, A. Yoshimura, J. Scott-Browne, A. Rao   +8 more
semanticscholar   +1 more source

Constructing a Model Using Clock‐Related lncRNAs for Predicting the Tumor Microenvironment of Gliomas

Brain and Behavior, Volume 15, Issue 10, October 2025.
Step 1: Identify hub clock‐related genes through differential expression analysis, univariate Cox analysis, and LASSO‐Cox regression; Step 2: Identify and screen hub clock‐related lncRNAs using correlation analysis and LASSO‐Cox regression; Step 3: Validate the expression differences of the selected lncRNAs in cell experiments using qPCR.
Mingjie Gong, Chengfa Sun, Zhenhua Shi, Junxiang Wang, Weiwei Zhai, Zhengquan Yu   +5 more
wiley   +1 more source

Red Blood Cell‐Mediated Enhancement of Hematopoietic Stem Cell Functions via a Hes1‐Dependent Pathway

The FASEB Journal, Volume 39, Issue 17, 15 September 2025.
After chemotherapy, blood cell numbers initially decrease but later recover as hematopoietic progenitor cells increase. Following chemotherapy, RBC concentrations in bone marrow peaked at day 5, and direct contact between HSCs and RBCs increased. This contact induced elevated expression of Notch1 and Hes1 in HSCs. Hes1‐deficient HSCs and treatment with
Erika Yamashita, Soichiro Hashimoto, Hiroaki Abe, Takao Sudo, Daisuke Okuzaki, Toshiya Okawa, Masaru Ishii   +6 more
wiley   +1 more source

External Cues as Transducers of Peripheral Tissue‐Specific Molecular Clocks to Regulate Systemic Circadian Rhythms and Metabolism

The FASEB Journal, Volume 39, Issue 17, 15 September 2025.
Tissue‐specific circadian clocks synchronize via diet, intestinal microbiota, and exercise. Time‐restricted feeding extends lifespan through synergistic action of molecular clocks and autophagy, establishing rhythmicity and harmony in hepatic proteasome activity.
Zhe Zhang, Bei‐bei Liu, Shu‐zhe Ding
wiley   +1 more source

TOX and TOX2 transcription factors cooperate with NR4A transcription factors to impose CD8+ T cell exhaustion

Proceedings of the National Academy of Sciences of the United States of America, 2019
Significance A recent exciting development in cancer therapy involves using a patient’s own immune system to attack cancers. The attack is carried out by CD8+ T cells that destroy the malignant cells; after infiltrating tumors, however, these cells ...
Hyungseok Seo, Joyce Chen, Edahí González-Avalos, Daniela Samaniego-Castruita, Arundhoti Das, Yueqiang H. Wang, Isaac F. López-Moyado, Romain O. Georges, Wade Zhang, A. Onodera, Cheng-Jang Wu, Li-Fan Lu, P. Hogan, A. Bhandoola, A. Rao   +14 more
semanticscholar   +1 more source

The effects of graded levels of calorie restriction : XI. Evaluation of the main hypotheses underpinning the life extension effects of CR using the hepatic transcriptome [PDF]

, 2017
We would like to acknowledge the BSU staff for their invaluable help with caring for the animals.Peer reviewedPublisher ...
Chen, Luonan, Derous, Davina, Douglas, Alex, Green, Cara L, Han, Jing-Dong J, Lusseau, David, Mitchell, Sharon E, Promislow, Daniel E L, Speakman, John R, Wang, Lu, Wang, Yingchun   +10 more
core   +1 more source

Polymorphisms in the circadian expressed genes PER3 and ARNTL2 are associated with diurnal preference and GNβ3 with sleep measures [PDF]

, 2014
Sleep and circadian rhythms are intrinsically linked, with several sleep traits, including sleep timing and duration, influenced by both sleep homeostasis and the circadian phase.
Archer, Simon N, Barclay, Nicola L, Eley, Thalia C, Gregory, Alice M, Lester, Kathryn J, Nolan, Patrick M, Parsons, Michael J   +6 more
core   +2 more sources