Results 61 to 70 of about 677,732 (163)

Sex Differences in Doxorubicin‐Induced Cardiotoxicity: Insights from Transcriptome Analysis

Advanced Therapeutics, Volume 7, Issue 9, September 2024.
Uncovering the molecular mechanisms of sex difference in DOX (doxorubicin)‐induced cardiotoxicity is important for DOX's application in male and female patients with cancer. The results of this study show that after DOX treatment, males and females have significantly different patterns of differentially expressed gene.
Qingqing Su, Min Fu, Wanli Xiao, Huan Zhao, Yang Yu, Jianguo Feng, Yulin Liu, Ying Wan, Yajun Yu, Chunxiang Zhang   +9 more
wiley   +1 more source

Dysregulation of circadian clock gene expression patterns in a treatment‐resistant animal model of depression

Journal of Neurochemistry, Volume 168, Issue 9, Page 1826-1841, September 2024.
Major depressive disorder is commonly accompanied by circadian rhythm (CR) disturbances in the form of sleep pattern and hormonal rhythm disruption. These CR disturbances have been linked to alterations in the circadian expression patterns of circadian clock genes (ccgs) in various tissues, including the brain. Here, we investigate the dysregulation of
Kristoffer Højgaard, Erik Kaadt, Birgitte Hviid Mumm, Vitor Silva Pereira, Betina Elfving   +4 more
wiley   +1 more source

Targeting Transcription Factors for Cancer Treatment

Molecules, 2018
Transcription factors are involved in a large number of human diseases such as cancers for which they account for about 20% of all oncogenes identified so far. For long time, with the exception of ligand-inducible nuclear receptors, transcription factors
M. Lambert, S. Jambon, S. Depauw, M. David-Cordonnier   +3 more
semanticscholar   +1 more source

Intestinal microbiota by angiotensin receptor blocker therapy exerts protective effects against hypertensive damages

iMeta, Volume 3, Issue 4, August 2024.
16S rRNA sequencing, liquid chromatography‐tandem mass spectrometry, RNA sequencing and immunofluorescence staining were combined to assess the role of ARB‐modified gut microbes. ARB‐modified gut microbiota exert protective roles in hypertension, vascular remodeling and injury, metabolic abnormality and intestinal dysfunctions, suggesting a pivotal ...
Jing Li, Si‐Yuan Wang, Kai‐Xin Yan, Pan Wang, Jie Jiao, Yi‐Dan Wang, Mu‐Lei Chen, Ying Dong, Jiu‐Chang Zhong   +8 more
wiley   +1 more source

Negative Example Aided Transcription Factor Binding Site Search [PDF]

arXiv, 2011
Computational approaches to transcription factor binding site identification have been actively researched for the past decade. Negative examples have long been utilized in de novo motif discovery and have been shown useful in transcription factor binding site search as well.
arxiv  

WRKY transcription factors in plant responses to stresses.

Journal of Integrative Plant Biology, 2017
The WRKY gene family is among the largest families of transcription factors (TFs) in higher plants. By regulating the plant hormone signal transduction pathway, these TFs play critical roles in some plant processes in response to biotic and abiotic ...
Jingjing Jiang, Shenghui Ma, Nenghui Ye, Ming Jiang, Jiashu Cao, Jianhua Zhang   +5 more
semanticscholar   +1 more source

Age‐related dysregulation of the retinal transcriptome in African turquoise killifish

Aging Cell, Volume 23, Issue 8, August 2024.
Transcriptomic analysis of the ageing killifish retina showed a marked upregulation of processes observed to be altered in the aged human retina and brain, including oxidative stress, gliosis, and inflammageing. Single‐cell RNA sequencing unveiled the cellular heterogeneity of the killifish retina, while the integration of both bulk and single‐cell ...
Steven Bergmans, Nicole C. L. Noel, Luca Masin, Ellen G. Harding, Aleksandra M. Krzywańska, Julie D. De Schutter, Rajagopal Ayana, Chi‐Kuo Hu, Lut Arckens, Philip A. Ruzycki, Ryan B. MacDonald, Brian S. Clark, Lieve Moons   +12 more
wiley   +1 more source

Transcription-driven genome organization: a model for chromosome structure and the regulation of gene expression tested through simulations [PDF]

Nucleic Acids Res. 46, 9895 (2018), 2020
Current models for the folding of the human genome see a hierarchy stretching down from chromosome territories, through A/B compartments and TADs (topologically-associating domains), to contact domains stabilized by cohesin and CTCF. However, molecular mechanisms underlying this folding, and the way folding affects transcriptional activity, remain ...
arxiv  

WRKY Transcription Factors: Molecular Regulation and Stress Responses in Plants

Frontiers in Plant Science, 2016
Plants in their natural habitat have to face multiple stresses simultaneously. Evolutionary adaptation of developmental, physiological, and biochemical parameters give advantage over a single window of stress but not multiple.
Ujjal J Phukan, G. Jeena, R. Shukla
semanticscholar   +1 more source

ARNTL hypermethylation promotes tumorigenesis and inhibits cisplatin sensitivity by activating CDK5 transcription in nasopharyngeal carcinoma

Journal of experimental & clinical cancer research : CR, 2019
Increasing evidence support an important role for DNA methylation in nasopharyngeal carcinoma (NPC). Here, we explored the role of circadian clock gene Aryl Hydrocarbon Receptor Nuclear Translocator-Like (ARNTL) methylation in NPC.
Hao-ran Peng, J. Zhang, Panpan Zhang, Lei Chen, L. Tang, Xiao-jing Yang, Qingmei He, Xin Wen, Ying Sun, Na Liu, Yingqin Li, Jun Ma   +11 more
semanticscholar   +1 more source