Results 71 to 80 of about 167,712 (159)
The circadian rhythm: A key variable in aging?
Aging Cell, Volume 23, Issue 11, November 2024.In this study, general age‐related transcriptional trajectories in seven organs were investigated over the lifespan of mice. Since both sexes and two strains were used equally, biases in this regard are diminished. Twenty replicas per time provide a deeper insight than usual.
Patrick R. Winterhalter +4 more
wiley +1 more source
Sex Differences in Doxorubicin‐Induced Cardiotoxicity: Insights from Transcriptome Analysis
Advanced Therapeutics, Volume 7, Issue 9, September 2024.Uncovering the molecular mechanisms of sex difference in DOX (doxorubicin)‐induced cardiotoxicity is important for DOX's application in male and female patients with cancer. The results of this study show that after DOX treatment, males and females have significantly different patterns of differentially expressed gene.
Qingqing Su +9 more
wiley +1 more source
Molecular Oncology, Volume 19, Issue S1, Page 1-895, June 2025.Abstracts submitted to the ‘EACR 2025 Congress: Innovative Cancer Science’, from 16–19 June 2025 and accepted by the Congress Organising Committee are published in this Supplement of Molecular Oncology, an affiliated journal of the European Association for Cancer Research (EACR).
wiley +1 more source
Journal of Neurochemistry, Volume 168, Issue 9, Page 1826-1841, September 2024.Major depressive disorder is commonly accompanied by circadian rhythm (CR) disturbances in the form of sleep pattern and hormonal rhythm disruption. These CR disturbances have been linked to alterations in the circadian expression patterns of circadian clock genes (ccgs) in various tissues, including the brain. Here, we investigate the dysregulation of
Kristoffer Højgaard +4 more
wiley +1 more source
iMeta, Volume 3, Issue 4, August 2024.16S rRNA sequencing, liquid chromatography‐tandem mass spectrometry, RNA sequencing and immunofluorescence staining were combined to assess the role of ARB‐modified gut microbes. ARB‐modified gut microbiota exert protective roles in hypertension, vascular remodeling and injury, metabolic abnormality and intestinal dysfunctions, suggesting a pivotal ...
Jing Li +8 more
wiley +1 more source
Negative Example Aided Transcription Factor Binding Site Search [PDF]
arXiv, 2011 Computational approaches to transcription factor binding site identification have been actively researched for the past decade. Negative examples have long been utilized in de novo motif discovery and have been shown useful in transcription factor binding site search as well.
arxiv
Transcription-driven genome organization: a model for chromosome structure and the regulation of gene expression tested through simulations [PDF]
Nucleic Acids Res. 46, 9895 (2018), 2020 Current models for the folding of the human genome see a hierarchy stretching down from chromosome territories, through A/B compartments and TADs (topologically-associating domains), to contact domains stabilized by cohesin and CTCF. However, molecular mechanisms underlying this folding, and the way folding affects transcriptional activity, remain ...
arxiv
The clock protein period 2 synchronizes mitotic expansion and decidual transformation of human endometrial stromal cells [PDF]
, 2015 Implantation requires coordinated interactions between the conceptus and surrounding decidual cells, but the involvement of clock genes in this process is incompletely understood.
Brighton, Paul (Paul J.) +8 more
core +2 more sources
Polymorphisms in the circadian expressed genes PER3 and ARNTL2 are associated with diurnal preference and GNβ3 with sleep measures [PDF]
, 2014 Sleep and circadian rhythms are intrinsically linked, with several sleep traits, including sleep timing and duration, influenced by both sleep homeostasis and the circadian phase.
Archer, Simon N +6 more
core +2 more sources
A Computational Analysis of Alternative Splicing across Mammalian Tissues Reveals Circadian and Ultradian Rhythms in Splicing Events [PDF]
, 2019 Mounting evidence points to a role of the circadian clock in the temporal regulation of post-transcriptional processes in mammals, including alternative splicing (AS).
El-Athman, Rukeia +3 more
core +1 more source