The Role of Ferroptosis in Women's Health and Diseases
MedComm, Volume 6, Issue 8, August 2025.At present, there are many common women's diseases, such as preeclampsia (PE), ovarian cancer, and cervical cancer, endangering women's health. These diseases all over the world are characterized by high morbidity and mortality. In the past decade, ferroptosis, a unique pattern of programmed cell death primarily driven by iron‐dependent phospholipid ...
Qiang Xu +5 more
wiley +1 more source
Deciphering the dynamic code: DNA recognition by transcription factors in the ever-changing genome
TranscriptionTranscription factors (TFs) intricately navigate the vast genomic landscape to locate and bind specific DNA sequences for the regulation of gene expression programs.
Yumi Minyi Yao +4 more
semanticscholar +1 more source
Comparing circadian dynamics in primary derived stem cells from different sources of human adult tissue [PDF]
, 2017 Optimising cell/tissue constructs so that they can be successfully accepted and integrated within a host body is essential in modern tissue engineering. To do this, adult stem cells are frequently utilised, but there are many aspects of their environment
Fawcett, SA +3 more
core +2 more sources
Circadian Gene BMAL1 Regulation of Cellular Senescence in Thyroid Aging
Aging Cell, Volume 24, Issue 8, August 2025.BMAL1 downregulation during aging reduces NFKBIA expression, accelerating thyroid cellular senescence and impairing hormone synthesis. Circadian rhythm disruption exacerbates thyroid functional decline, highlighting the BMAL1‐NFKBIA axis as a key mediator of aging‐related thyroid dysfunction and offering insights for stabilizing thyroid health in aging
Dandan Zong +4 more
wiley +1 more source
PlantTFDB 4.0: toward a central hub for transcription factors and regulatory interactions in plants
Nucleic Acids Res., 2016 With the goal of providing a comprehensive, high-quality resource for both plant transcription factors (TFs) and their regulatory interactions with target genes, we upgraded plant TF database PlantTFDB to version 4.0 (http://planttfdb.cbi.pku.edu.cn ...
Jinpu Jin +6 more
semanticscholar +1 more source
Circadian Rhythm Abnormalities in Parkinson's Disease from Humans to Flies and Back [PDF]
, 2018 Clinical and research studies have suggested a link between Parkinson\u2019s disease (PD) and alterations in the circadian clock. Drosophila melanogaster may represent a useful model to study the relationship between the circadian clock and PD.
Bisaglia, Marco +3 more
core +1 more source
The Emerging Role of Epigenetic Modifiers in Repair of DNA Damage Associated with Chronic Inflammatory Diseases [PDF]
, 2017 At sites of chronic inflammation epithelial cells are exposed to high levels of reactive oxygen species (ROS), which can contribute to the initiation and development of many different human cancers.
Ding, Ning +2 more
core +1 more source
MicroRNA-433 Dampens Glucocorticoid Receptor Signaling, Impacting Circadian Rhythm and Osteoblastic Gene Expression [PDF]
, 2016 FUNDING This work was supported by the National Institute of Arthritis and Musculoskeletal and Skin Diseases of the National Institutes of Health [AR44877]; the National Institutes for Dental and Craniofacial Research [5T90DE21989]; a Grant-in-Aid award ...
Delany, Anne M +4 more
core +1 more source
Molecular mechanisms in mood regulation involving the circadian clock [PDF]
, 2017 The circadian system coordinates activities and functions in cells and tissues in order to optimize body functions in anticipation to daily changes in the environment.
Albrecht, Urs
core +1 more source
The Interplay between Colon Cancer Cells and Tumour-Associated Stromal Cells Impacts the Biological Clock and Enhances Malignant Phenotypes [PDF]
, 2019 Cancer cells interrelate with the bordering host microenvironment that encompasses the extracellular matrix and a nontumour cellular component comprising fibroblasts and immune-competent cells.
Abreu, Mónica +7 more
core +1 more source