Large-scale comparative genomics and structure-function analysis enables characterization of known and novel genetic determinants of antimicrobial resistance in bacterial pathogens. [PDF]
Mannion A +3 more
europepmc +1 more source
Factors Associated With Receipt of Adjuvant Radiation in Locally Advanced Rectal Cancer
ABSTRACT Background Neoadjuvant radiotherapy (RT) has been the standard of care for locally advanced rectal cancer (LARC) for over two decades. Adjuvant RT use in LARC represents a deviation from standard care and warrants further investigation. Objectives To identify factors associated with adjuvant RT utilization.
Maryam Sherwani +4 more
wiley +1 more source
Improved Artificial Protozoa Optimizer-Based PI Control for Temperature and Power Regulation of PCM Thermal Energy Storage. [PDF]
Turkeri C.
europepmc +1 more source
Bispecific NK‐Cell Engager Targeting TP53 Mutation Through Integration of a TCR‐mimic Antibody
Most existing NK cell engagers (NKCEs) target tumor‐associated antigens (TAAs), risking on‐target, off‐tumor toxicity. We engineered a novel NKCE termed C33×CD16, a single‐chain diabody (scDb) constructed by fusing TCR‐mimic antibody C33‐Ab (targeting p53R175H/HLA‐A*02:01) to the scFv of 3G8 (anti‐CD16 antibody) (a).
Hanfei Wu +16 more
wiley +1 more source
Disrupted Vestibular Nuclei Neuron Development in a Chick Model for Congenital Vestibular Disorders. [PDF]
Bogin EB +5 more
europepmc +1 more source
Inverse Single-Strand RACE: An Adapter-Independent Method of 5′RACE
Yoram Eyal +3 more
doaj +1 more source
Atherosclerosis: From Pathogenesis to Therapeutic Interventions
The diagram outlines the core mechanisms driving atherosclerosis, including endothelial dysfunction, inflammatory responses, phenotypic switching of smooth muscle cells, and the gut–vascular axis. It also presents the corresponding therapeutic approaches now under development, such as gene therapies, immunotherapies, and nanotechnology platforms ...
Enge Zhou +9 more
wiley +1 more source
A chemically optimized, GalNAc-conjugated siRNA targeting HSD17B13 demonstrates efficacy in a human 3D organoid model of MASH, showcasing an alternative to animal testing. [PDF]
Meng Q +6 more
europepmc +1 more source
Abstract We analyze challenges and adaptation strategies of Nordic legal overseers, the Parliamentary Ombudsmen and Chancellors of Justice in Denmark, Finland, Norway and Sweden, amid the COVID‐19 crisis. We study how the accountability capacities of the legal overseers were affected when standard practices of inclusive decision‐making were severed ...
Tero Erkkilä +2 more
wiley +1 more source
DS-ARO: a multi-strategy improved artificial rabbits optimization algorithm for global optimization and corporate bankruptcy prediction. [PDF]
Bai X, Li Y.
europepmc +1 more source

