Results 71 to 80 of about 137,760 (296)

The Multitarget Compound ZLY032 Achieves Treatment of Chronic Wounds

Advanced Science, EarlyView.
ZLY032, a dual free fatty acid receptor 1/peroxisome proliferator‐activated receptor δ agonist, accelerates wound healing in normal/diabetic/methicillin‐resistant Staphylococcus aureus‐infected models by promoting angiogenesis, reducing inflammation, and exhibiting antibacterial activity via argininosuccinate lyase targeting, with demonstrated efficacy
Manyu Gong, Zhiyuan Du, Tiantian Gong, Yu Wang, Chenchen Yin, Bosi Sun, Zijia Liu, Lianru Chen, Zibin Liao, Wenxin Wang, Tianjiao Zhao, Yifei Wang, Ying Dong, Kexin Wang, Mengru Ma, Weijun Li, Jiacheng Li, Haodong Li, Congcong Lin, Ying Zhang, Yu Liu, Xin Liu, Tao Ban, Hongxia Bao, Ying Zhang, Yang Zhang, Zheng Li, Lei Jiao   +27 more
wiley   +1 more source

Normas de alerta e valência para 908 palavras da Língua Portuguesa

Psicologia: Teoria e Pesquisa
Normas de valência e alerta para 908 palavras foram coletadas utilizando-se a escala de julgamento SAM (Self-Assessment Manikin). Participaram do estudo 4.359 estudantes universitários oriundos de quatro universidades.
Nelson Rocha de Oliveira, Gerson Américo Janczura, Goiara Mendonça de Castilho   +2 more
doaj   +1 more source

Distance to the Neutral Face Predicts Arousal Ratings of Dynamic Facial Expressions in Individuals With and Without Autism Spectrum Disorder

Frontiers in Psychology, 2020
Arousal is one of the dimensions of core affect and frequently used to describe experienced or observed emotional states. While arousal ratings of facial expressions are collected in many studies it is not well understood how arousal is displayed in or ...
Jan N. Schneider, Jan N. Schneider, Timothy R. Brick, Isabel Dziobek   +3 more
doaj   +1 more source

A Water‐Triggered Sensor for Self‐Powered Flood Alarming

Advanced Science, EarlyView.
Urban floods related to global warming generally cause significant casualties. Traditional cable flood warning systems are costly, while wireless ones face power limitations. This research proposes a self‐powered flood sensor with a water‐triggered Galvanic battery, enabling rapid flood warnings with great promise of low cost and long service lifetime.
Mingqi Zhao, Shanzhi Lyu, Yingchao Ma, Nan Zhang, Yapei Wang   +4 more
wiley   +1 more source

Sleep Deprivation Activates a Conserved Lactate‐H3K18la‐RORα Axis Driving Neutrophilic Inflammation Across Species

Advanced Science, EarlyView.
Sleep deprivation triggers systemic immune activation characterized by neutrophil accumulation and cytokine release. This study reveals a conserved metabolic‒epigenetic mechanism whereby lactate‐induced H3K18 lactylation upregulates RORα expression, promoting neutrophilic inflammation.
Ren Zhou, Keyun Li, Xiezong Hu, Shuhao Fan, Yuxuan Gao, Xiaoshu Xue, Yu Bu, Haoyi Zhang, Yili Wang, Chunjiao Wei, Shangrong Zhang, Zhongwen Xie, Chao Liu, Peng Chen, Zongjun Yin, Dalong Ren   +15 more
wiley   +1 more source

Perovskite Neuromorphic Engine for Transformer Architectures

Advanced Science, EarlyView.
This paper introduces a perovskite‐based memristive computing unit that performs all necessary operations for Transformer artificial neural networks entirely in the analog domain. The system achieves comparable performance to GPU‐based systems, but with only 1.7% of the energy consumption, boosting power efficiency by 58 times.
Zhenye Zhan, Yulu Gao, Yue Liao, Weiguang Xie, Si Liu, Xiaomu Wang   +5 more
wiley   +1 more source

A Subcircuit in the Suprachiasmatic Nucleus Generates Wakefulness

Advanced Science, EarlyView.
This study identifies a sub‐circuit within the circadian pacemaker suprachiasmatic nucleus (SCN) that promotes arousal. This sub‐circuit is labeled by the clock output molecule mWAKE, which suppresses its excitability in a time‐dependent manner. mWAKE‐expressing cells in the SCN (SCNmWAKE cells) project to the subparaventricular zone (SPZ) to mediate ...
Qiang Liu, Sang Soo Lee, Jiali Xiong, Shahin Ahmadi, Benjamin J. Bell, Mehmet F. Keles, Mark N. Wu   +6 more
wiley   +1 more source

Skin Conductance as a Viable Alternative for Closing the Deep Brain Stimulation Loop in Neuropsychiatric Disorders

Frontiers in Neuroscience, 2019
Markers from local field potentials, neurochemicals, skin conductance, and hormone concentrations have been proposed as a means of closing the loop in Deep Brain Stimulation (DBS) therapy for treating neuropsychiatric and movement disorders. Developing a
Dilranjan S. Wickramasuriya, Md. Rafiul Amin, Rose T. Faghih   +2 more
doaj   +1 more source

Ultra‐Low Hysteresis Under Large Deformation Enabled by Fast Chains Relaxation in Highly Competitive Dynamic Hydrogen Bond Networks

Advanced Science, EarlyView.
This study demonstrates that incorporating deep eutectic solvent (DES) components tunes the relaxation dynamics of strong hydrogen bonds between polymer segments, rendering them mechanically “invisible” during service conditions (low hysteresis: <3%).
Shuaijun Guo, Shilei Zhu, Yang Qiao, Shanhao Feng, Xin Yang, Beibei Kang, Chaojun Yue, Yanjing Zhang, Zhuangzhuang Li, Ya Nan Ye, Qiang Zheng   +10 more
wiley   +1 more source

Plasma Metabolic Profile with Machine Learning Reveals Distinct Diagnostic and Biological Signatures for Pathologic Myopia

Advanced Science, EarlyView.
Plasma metabolic detection combined with machine learning offers a precise (area under the curve of 0.874) and high‐throughput (<30 s) diagnosis for pathologic myopia (serious myopic macular degeneration). The biomarkers indicate the pathologic myopia‐associated systemic metabolic reprogramming, which exhibits specificity for myopic macular ...
Ziheng Qi, Jiao Qi, Ye Zhang, Yanhui Wang, Yuchen Feng, Zifan Yang, Yating Wang, Weikang Shu, Dongling Guo, Ching Kang, Keke Zhang, Yi Lu, Jingjing Wan, Xiangjia Zhu   +13 more
wiley   +1 more source