Results 121 to 130 of about 21,961,403 (345)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

SAR processing on the MPP [PDF]

The processing of synthetic aperture radar (SAR) signals using the massively parallel processor (MPP) is discussed. The fast Fourier transform convolution procedures employed in the algorithms are described.
Batcher, K. E., Eddey, E. E., Faiss, R. O., Gilmore, P. A.   +3 more
core   +1 more source

The skills required for transition to university and study in biological sciences: A student perspective

FEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

Ghost Discrimination Method for Broadband Direct Position Determination Based on Frequency Coloring Technology

Journal of Marine Science and Engineering
Recently proposed direct position determination (DPD) methods have garnered considerable interest in passive localization due to their excellent positioning accuracy.
Mengling Yu, Long Yang, Yixin Yang, Xionghou Liu, Lu Wang   +4 more
doaj   +1 more source

Trends in Adaptive Array Processing

International Journal of Antennas and Propagation, 2012
Enormous progress has been made during the past five decades in the area of adaptive array processing. Increased computational power has resulted in many practical applications of optimum algorithms.
Hema Singh, Rakesh Mohan Jha
doaj   +1 more source

Parallel algorithms for interactive manipulation of digital terrain models [PDF]

Interactive three-dimensional graphics applications, such as terrain data representation and manipulation, require extensive arithmetic processing. Massively parallel machines are attractive for this application since they offer high computational rates,
Davis, E. W., Mcallister, D. F., Nagaraj, V.   +2 more
core   +1 more source

Space-based Aperture Array For Ultra-Long Wavelength Radio Astronomy

, 2015
The past decade has seen the rise of various radio astronomy arrays, particularly for low-frequency observations below 100MHz. These developments have been primarily driven by interesting and fundamental scientific questions, such as studying the dark ...
Arts, Michel, Belien, Frederik, Bentum, Mark, Boonstra, Albert-Jan, Klein-Wolt, Marc, Rajan, Raj Thilak, Saks, Noah, van der Veen, Alle-Jan   +7 more
core   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Optimization of design of space experiments from the standpoint of data processing Semiannual report, 1 Oct. 1967 - 31 Mar. 1968 [PDF]

Design and construction work on spacecraft array processor for onboard processing of experimental ...
Algazi, V. R., Sakrison, D. J., Silver, S.   +2 more
core   +1 more source

Frailty Exacerbates Disability in Progressive Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background To evaluate frailty in severe progressive multiple sclerosis (PMS) and to investigate the underlying mechanisms. Methods This prospective, cross‐sectional, multicenter study enrolled a late severe PMS group requiring skilled nursing (n = 53) and an age, sex, and disease duration‐matched control PMS group (n = 53).
Taylor R. Wicks, Anna Wolska, Diala Ghazal, Dejan Jakimovski, Bianca Weinstock‐Guttman, Alexander Burnham, Niels Bergsland, Michael G. Dwyer, Alan T. Remaley, Robert Zivadinov, Murali Ramanathan   +10 more
wiley   +1 more source