Results 51 to 60 of about 7,913 (283)
Trends in Genetics, 2017 Evolution in the form of selective breeding has long been harnessed as a useful tool by humans. However, rapid evolution can also be a danger to our health and a stumbling block for biotechnology. Unwanted evolution can underlie the emergence of drug and pesticide resistance, cancer, and weeds.
James J, Bull, Jeffrey E, Barrick
openaire +2 more sources
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
The Effect of Cable Aging on Surge Arresters Designed by Genetic Algorithm
Applied Sciences, 2023 The degradation of communication cable insulators reduces the availability of the train control system and is caused by the degrading of data transmission line parameters.
Dariusz Zieliński, Damian Grzechca
doaj +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
PENENTUAN JARAK ARRESTER DENGAN TRANSFORMATOR DI PT.PLN LEUNG BATA CABANG BANDA ACEH [PDF]
, 2015 Setiap industri besar membutuhkan sumber energi listrik yang besar. Melihat pengaruhnya terhadap tegangan abnormal yang tiba pada transformator. Arrester adalah alat proteksi bagi peralatan listrik terhadap tegangan lebih yang disebabkan oleh petir atau ...
Risma Afdhal
core
Analysis of transmission lightning arrester locations using Tflash [PDF]
, 2016 Tropical countries with extensive lightning activity, such as Malaysia, encounter numerous problems on their electrical transmission and distribution systems.
Arief, Y. Z. +8 more
core +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Condition Assessment of Metal Oxide Surge Arrester Based on Multi-Layer SVM Classifier
Iranian Journal of Electrical and Electronic Engineering, 2015 This paper introduces the indicators for surge arrester condition assessment based on the leakage current analysis. Maximum amplitude of fundamental harmonic of the resistive leakage current, maximum amplitude of third harmonic of the resistive leakage ...
M Khodsuz, M Mirzaie
doaj
Comparison of transformer modeling on riser pole arresters behavior during switching transients
Archives of Electrical Engineering, 2017 Arresters are widely used in power systems to protect other equipment against overvoltages. However, in some conditions, they can’t operate successfully.
Abbaszadeh Amir +2 more
doaj +1 more source