Novel Crack Stopper Concept for Lightweight Foam Cored Sandwich Structures – Experimental Validation, Fe-Modelling and Potential for Use in Structures [PDF]
, 2016 Andreasen, Jens H. +3 more
core
KDM4A Erases the H3R17me2a Mark, Facilitating Chromosome Condensation
Advanced Science, EarlyView.This study reveals a reversible histone modification switch governing chromosome condensation during mitosis. PKCα‐activated KDM4A removes H3R17me2a, permitting Suv39h1‐driven H3K9me3 deposition. This epigenetic transition recruits the chromosomal passenger complex and triggers Aurora B‐dependent H3S10 phosphorylation, coordinating chromatin remodeling
Yena Cho +6 more
wiley +1 more source
Advanced Science, EarlyView.Phospholipase A2 (PLA2), a dormant enzyme, becomes lethal when activated—collapsing lungs in minutes. Our dual therapy (DOPS + varespladib) boosts survival from 0% to >90% in sepsis/ALI. A breakthrough for acute lung injury treatment. ABSTRACT This study reveals that phospholipase A2 (PLA2), normally stable and nontoxic, can be activated specifically ...
Jianyu Wang +7 more
wiley +1 more source
Assessment of the Risk of Failure in Electric Power Supply Systems for Railway Traffic Control Devices. [PDF]
Sensors (Basel)Ciszewski T +5 more
europepmc +1 more source
On the Origins of Toughness in Corymbia calophylla (Marri Tree) Nuts
Advanced Science, EarlyView.We uncover the natural toughening mechanisms of the marri nut, including fiber pullout, crack deflection, and a viscoelastic matrix, which enable exceptional energy absorption and ductility comparable to Teflon, with an elastic modulus similar to acrylic.
Wegood M. Awad +7 more
wiley +1 more source
Exploring the surge current degradation of natural ester oil-based nanofluids. [PDF]
Sci RepTsovilis T +4 more
europepmc +1 more source
Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy
Advanced Science, EarlyView.Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong +5 more
wiley +1 more source
Study of the Microstructure Characterization and In Situ Observation of Crack Propagation in TC4/Al<sub>3</sub>Ti Metal-Intermetallic Laminated Composites. [PDF]
Materials (Basel)Miao Y, Shi Y, Wang W, Ding X, Zhang S.
europepmc +1 more source
Industrial metabolism: a case study of the economics of cadmium control [PDF]
, 2009 Klepper, Gernot +2 more
core