Results 171 to 180 of about 194,646 (286)

Non‐invasive assessment of integrated cardiorespiratory network dynamics after physiological stress in humans

The Journal of Physiology, EarlyView.
Abstract figure legend This study aimed to develop a non‐invasive method for visualizing the cardiorespiratory network under baseline conditions and following isolated or combined exposure to hypoxia, exercise, and sleep deprivation. Twenty‐two healthy participants underwent assessments at rest and after normobaric hypoxia (FIO2${{F}_{{\mathrm{I ...
Cecilia Morandotti, Louise Rigny, Thomas B. Williams, Juan I. Badariotti, Matt Miller‐Dicks, Amar S. Bhogal, Shachula Han, Jo Corbett, Michael J. Tipton, Joseph T. Costello, Ali R. Mani   +10 more
wiley   +1 more source

Mahaim Tachycardia Mimicking Ventricular Tachycardia. [PDF]

JACC Case Rep
Davtyan K, Topchyan A, Bazaeva E, Brutyan H.   +3 more
europepmc   +1 more source

Computational modelling of cardiac fibroblast signalling reveals a key role for Ca2+ in driving atrial fibrillation‐associated fibrosis

The Journal of Physiology, EarlyView.
Abstract figure legend A pre‐existing fibroblast signalling model was enhanced by integrating atrial‐specific components and reactions linked to atrial fibrosis and atrial fibrillation (AF). The analysis highlights the central role of Ca2⁺ signalling in driving profibrotic responses to AF‐relevant stimuli, angiotensin‐II and transforming growth factor ...
Najme Khorasani, Haibo Ni, Jeffrey J Saucerman, Dobromir Dobrev, Stefano Morotti, Eleonora Grandi   +5 more
wiley   +1 more source

Mechanistic insights into sex differences in atrial electrophysiology and arrhythmia vulnerability through sex‐specific computational models

The Journal of Physiology, EarlyView.
Abstract figure legend Sex‐specific models of the human atrial myocyte in normal sinus rhythm (nSR) and chronic atrial fibrillation (cAF) revealed increased alternans susceptibility in cAF males and DADs in females, driven primarily by ICaL and ryanodine receptor remodelling.
Nathaniel T. Herrera, Haibo Ni, Charlotte E. R. Smith, Yixuan Wu, Dobromir Dobrev, Stefano Morotti, Eleonora Grandi   +6 more
wiley   +1 more source

Cardiac Arrest in a Young Soccer Player With a Pathogenic SCN5A Variant. [PDF]

JACC Case Rep
Sigal IR, Power J, Kontorovich AR, Musikantow D.   +3 more
europepmc   +1 more source

Caenorhabditis elegans as an in vivo model system for human inherited primary arrhythmia syndromes

The Journal of Physiology, EarlyView.
Abstract figure legend Most genes involved in inherited primary arrhythmia syndromes (IPAS) are conserved in Caenorhabditis elegans, where genetic manipulation enables functional characterization of variants, identification of regulatory proteins, and in vivo drug testing.
Antoine Delinière, Thomas Boulin, Maëlle Jospin, Alexandre Janin, Gilles Millat, Philippe Chevalier, Olga Andrini   +6 more
wiley   +1 more source

Cardioneuroablation for Functional Atrioventricular Block: Let Physiology Lead the Way. [PDF]

JACC Case Rep
Pachon-M JC, Pachon CTC, Granjeiro AHK.
europepmc   +1 more source

The multicellular environment of the re‐entrant circuit in post‐myocardial infarction ventricular tachycardia: Beyond fibrosis

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic overview of the temporal evolution of the post‐myocardial infarction substrate leading to ventricular tachycardia. Acute ischaemic injury initiates metabolic and electrophysiological disruption, followed by progressive inflammatory, fibrotic and structural remodelling within the infarct border zone.
Mohammed Obeidat, Jaffar Al‐Sheikhli, Andrew M. Blanks, Joseph Mayer, Nicolas Lellouche, Tarvinder Dhanjal, Christopher O'Shea   +6 more
wiley   +1 more source

Stokes-Adams Syncope and Ventricular Standstill. [PDF]

J Arrhythm
Shakfeh K, Yamada T, Saini A.
europepmc   +1 more source

An age‐associated decline in the role of the sarcoplasmic reticulum and associated calcium‐handling proteins sets the pace for sinoatrial node function

The Journal of Physiology, EarlyView.
Abstract figure legend Stable, responsive pacemaking in the sinoatrial node is driven by the activity of the funny current (membrane clock), interplay of calcium cycling and release from the sarcoendoplasmic reticulum with depolarising sodium‐calcium exchange current (calcium clock). With increasing age, key proteins associated with calcium cycling are
Sandra A. Jones, Fiona S. Godbeer, Matthew K. Lancaster   +2 more
wiley   +1 more source