Results 171 to 180 of about 196,577 (286)

A new approach to an old disease: Ageing, arrhythmogenic substrate and the role of risk‐factor modification in atrial fibrillation

Experimental Physiology, EarlyView.
Abstract Atrial fibrillation (AF) prevalence rises sharply with age due to two independent mechanisms. Ageing produces irreversible arrhythmogenic substrate changes through progressive fibrosis, cellular senescence and mitochondrial dysfunction, while modifiable risk factors such as obesity, hypertension, sleep apnoea, diabetes and alcohol use promote ...
Udit Thakur, Jonathan M. Kalman
wiley   +1 more source

Electrophysiological Changes in Children with Isolated Persistent Left Superior Vena Cava: A Case-Control Study. [PDF]

J Clin Med
Arici S, Surekli Karakus O, Yagar Keskin G, Tas E, Genc FA, Bayraktar S, Sungur M, Yildirim AI.   +7 more
europepmc   +1 more source

Senolytics and exercise: Dual modalities for rejuvenating muscle

The Journal of Physiology, EarlyView.
Abstract figure legend The role of senolytics on the heart and skeletal muscle. Senescent cell burden increases with ageing, disuse and disease. The senolytics dasatinib+quercetin (D+Q), navitoclax and fisetin, as well as exercise, eliminate senescent cells, reducing senescent cell burden and their senescence‐associated secretory phenotype (SASP ...
Zeynep Elif Yesilyurt‐Dirican, Ce Qi, Uchenna Okpechi, Maya Strand Ford, Georgina M. Ellison‐Hughes   +4 more
wiley   +1 more source

Junctional Ectopic Tachycardia After Adult Cardiac Surgery. [PDF]

JACC Case Rep
Jordan A, Zeljković I, Tomić SS, Lisičić A, Bušić N, Rode F, Manola Š, Pavlović N.   +7 more
europepmc   +1 more source

Deciphering pro‐arrhythmogenic mechanisms of EPAC in human atrial cardiomyocytes

The Journal of Physiology, EarlyView.
Abstract figure legend This study aimed to investigate the effect of exchange proteins directly activated by cAMP (EPAC) on the regulation of human atrial cardiomyocyte electrophysiology and their potential involvement in the onset of atrial fibrillation (AF).
Arthur Boileve, Margaux Aize, Maximin Détrait, Laura Brard, Adrien Leboyer, Pierre‐Antoine Dupont, Alexandre Lebrun, Vladimir Saplacan, Christophe Simard, Fabien Brette, Frank Lezoualc'h, Laurent Sallé   +11 more
wiley   +1 more source

An Abrupt Doubling of Heart Rate. [PDF]

JACC Case Rep
Kawji MM.
europepmc   +1 more source

Non‐invasive assessment of integrated cardiorespiratory network dynamics after physiological stress in humans

The Journal of Physiology, EarlyView.
Abstract figure legend This study aimed to develop a non‐invasive method for visualizing the cardiorespiratory network under baseline conditions and following isolated or combined exposure to hypoxia, exercise, and sleep deprivation. Twenty‐two healthy participants underwent assessments at rest and after normobaric hypoxia (FIO2${{F}_{{\mathrm{I ...
Cecilia Morandotti, Louise Rigny, Thomas B. Williams, Juan I. Badariotti, Matt Miller‐Dicks, Amar S. Bhogal, Shachula Han, Jo Corbett, Michael J. Tipton, Joseph T. Costello, Ali R. Mani   +10 more
wiley   +1 more source

A Complex Arrhythmic Phenotype in a Pediatric Patient with Variants in <i>SCN5A</i> and <i>KCNH2</i>. [PDF]

Genes (Basel)
Bienjonetti-Boudreau D, Tremblay-Laganiere C, Gkogkou E, Martinez A, Gonzalez Corcia C.   +4 more
europepmc   +1 more source

Computational modelling of cardiac fibroblast signalling reveals a key role for Ca2+ in driving atrial fibrillation‐associated fibrosis

The Journal of Physiology, EarlyView.
Abstract figure legend A pre‐existing fibroblast signalling model was enhanced by integrating atrial‐specific components and reactions linked to atrial fibrosis and atrial fibrillation (AF). The analysis highlights the central role of Ca2⁺ signalling in driving profibrotic responses to AF‐relevant stimuli, angiotensin‐II and transforming growth factor ...
Najme Khorasani, Haibo Ni, Jeffrey J Saucerman, Dobromir Dobrev, Stefano Morotti, Eleonora Grandi   +5 more
wiley   +1 more source