INFLUENCE OF THE AUTONOMIC NERVOUS SYSTEM UPON SPONTANEOUS CARDIAC ARRHYTHMIAS DURING CYCLOPROPANE ANESTHESIA [PDF]
, 1945 CHARLES R. ALLEN +3 more
openalex +1 more source
ChemMedChem, EarlyView.Heart failure involves reduced SERCA2a activity, crucial for calcium regulation in heart cells. This study reports machine learning screening of 57,423 natural products, identifying several structurally related SERCA2a activators. Three compounds enhance calcium transport in cardiac cells, despite off‐target effects, offering promising hits for ...
Carlos Cruz‐Cortés +7 more
wiley +1 more source
Leveraging Visibility Graphs for Enhanced Arrhythmia Classification with Graph Convolutional Networks [PDF]
arXivArrhythmias, detectable through electrocardiograms (ECGs), pose significant health risks, underscoring the need for accurate and efficient automated detection techniques. While recent advancements in graph-based methods have demonstrated potential to enhance arrhythmia classification, the challenge lies in effectively representing ECG signals as graphs.
arxiv
ChemMedChem, Accepted Article.The work presented herein outlines the ongoing structure‐activity relationship (SAR) studies centered around a potent, efficacious, and selective activators of the GIRK1/2 channel. Optimization studies centered around the pyrazole privileged scaffold, the N‐1‐position of the pyrazole and the right‐hand ether.
Sumaiya Nahid +8 more
wiley +1 more source
A Clinical Lecture ON SOME FORMS OF CARDIAC ARRHYTHMIA FROM THE POINT OF VIEW OF THE MYOGENIC THEORY: One of a Course of Lectures and Demonstrations given by the Staff of the Hospital for Diseases of the Chest, Brompton [PDF]
, 1908 W. J. Fenton
openalex +1 more source
The Significance of Arrhythmias and Systolic Murmurs in Relation to Cardiac Efficiency [PDF]
, 1917 Henry A. Christian
openalex +1 more source
Clinical Pharmacology in Drug Development, EarlyView.Abstract Dordaviprone (ONC201) is a novel, small molecule imipridone with antitumor effects in glioma patients. This study evaluated the pharmacokinetics and safety of dordaviprone following single escalating doses (Part A), as a capsule content mixed with applesauce or Gatorade (sports drink) [Part B1]), and with or without food [Part B2].
Shamia L. Faison +7 more
wiley +1 more source
Respiratory Arrhythmia and Change in Cardiac Rate in Hypertensive Patients with Change of Posture
, 1953 K Itahara +3 more
openalex +2 more sources
NON-TECHNICAL DIFFERENTIATION OF CARDIAC ARRHYTHMIAS [PDF]
, 1915 Wilfred M. Barton
openalex +1 more source
QTc Interval Changes in Preeclampsia vs. Normal Pregnancy: A Systematic Review and Meta‐Analysis
Clinical Pharmacology &Therapeutics, EarlyView.Pregnancy induces significant adaptations in the cardio‐autonomic nervous system, with additional cardiac stress in preeclampsia potentially impacting ventricular repolarization. Despite the widespread use of QT‐prolonging drugs during pregnancy, the extent of heart rate (HR)‐corrected QT (QTc) interval changes during normal pregnancy and preeclampsia ...
Omar A. Aboshady +4 more
wiley +1 more source