Results 211 to 220 of about 489,421 (410)

Leveraging Visibility Graphs for Enhanced Arrhythmia Classification with Graph Convolutional Networks [PDF]

arXiv
Arrhythmias, detectable through electrocardiograms (ECGs), pose significant health risks, underscoring the need for accurate and efficient automated detection techniques. While recent advancements in graph-based methods have demonstrated potential to enhance arrhythmia classification, the challenge lies in effectively representing ECG signals as graphs.
arxiv  

Machine Learning‐Driven Discovery of Structurally Related Natural Products as Activators of the Cardiac Calcium Pump SERCA2a

ChemMedChem, EarlyView.
Heart failure involves reduced SERCA2a activity, crucial for calcium regulation in heart cells. This study reports machine learning screening of 57,423 natural products, identifying several structurally related SERCA2a activators. Three compounds enhance calcium transport in cardiac cells, despite off‐target effects, offering promising hits for ...
Carlos Cruz‐Cortés, Eli Fernández‐de Gortari, Rodrigo Aguayo‐Ortiz, Jaroslava Šeflová, Adam Ard, Martin Clasby, Justus Anumonwo, L. Michel Espinoza‐Fonseca   +7 more
wiley   +1 more source

Deporte y síndromes arritmogénicos hereditarios (Sport and inherited arrhythmogenic syndromes)

Retos: Nuevas Tendencias en Educación Física, Deportes y Recreación
Los síndromes arritmogénicos hereditarios son un grupo de patologías cardiacas asociadas a arritmias malignas y un mayor riesgo de muerte súbita cardiaca, en ocasiones la primera manifestación de la patología.
Georgia Sarquella-Brugada, Estefanía Martínez-Barrios, Sergio Cesar, Elena Arbelo, Carles Diez, Oscar Campuzano Larrea   +5 more
doaj   +1 more source

Osborn Waves: History and Significance [PDF]

, 2004
The Osborn wave is a deflection with a dome or hump configuration occurring at the R-ST junction (J point) on the ECG (Fig. 1). In the historical view, different names have been used for this wave in the medical literature, such as “camel-hump sign ...
Atarashi, Hirotsugu, Hirayama, Yoshiyuki, Katoh, Takao, Kobayashi, Yoshinori, Kodani, Eitaroh, Maruyama, Mitsunori, Takano, Teruo   +6 more
core   +2 more sources

A Clinical Lecture ON SOME FORMS OF CARDIAC ARRHYTHMIA FROM THE POINT OF VIEW OF THE MYOGENIC THEORY: One of a Course of Lectures and Demonstrations given by the Staff of the Hospital for Diseases of the Chest, Brompton [PDF]

, 1908
W. J. Fenton
openalex   +1 more source

Further SAR of GIRK1/2 activators: Synthesis and Biological Characterization of In Vitro Tool Compounds

ChemMedChem, Accepted Article.
The work presented herein outlines the ongoing structure‐activity relationship (SAR) studies centered around a potent, efficacious, and selective activators of the GIRK1/2 channel. Optimization studies centered around the pyrazole privileged scaffold, the N‐1‐position of the pyrazole and the right‐hand ether.
Sumaiya Nahid, Fahad Imtiaz Rahman, Yu Du, Brittany Spitznagel, Sandeep K Singh, Yashpal Chhonker, Daryl J Murry, David Weaver, Corey R Hopkins   +8 more
wiley   +1 more source

The Significance of Arrhythmias and Systolic Murmurs in Relation to Cardiac Efficiency [PDF]

, 1917
Henry A. Christian
openalex   +1 more source

Respiratory Arrhythmia and Change in Cardiac Rate in Hypertensive Patients with Change of Posture

, 1953
K Itahara, Denjiro Musha, Gen Sato, Masataka Kato   +3 more
openalex   +2 more sources

NON-TECHNICAL DIFFERENTIATION OF CARDIAC ARRHYTHMIAS [PDF]

, 1915
Wilfred M. Barton
openalex   +1 more source

A Phase 1 Randomized Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of Single Escalating Oral Doses of Dordaviprone and the Effects of Food on the Bioavailability of Dordaviprone in Healthy Adult Subjects

Clinical Pharmacology in Drug Development, EarlyView.
Abstract Dordaviprone (ONC201) is a novel, small molecule imipridone with antitumor effects in glioma patients. This study evaluated the pharmacokinetics and safety of dordaviprone following single escalating doses (Part A), as a capsule content mixed with applesauce or Gatorade (sports drink) [Part B1]), and with or without food [Part B2].
Shamia L. Faison, Joelle Batonga, Thangam Arumugham, Angela Bartkus, Marion Morrison, Mark J. Mullin, Tim Tippin, Odin Naderer   +7 more
wiley   +1 more source