Results 151 to 160 of about 1,896,797 (391)

Time's Arrow, Friday, December 8, 2000 [PDF]

open access: yes, 2000
This is the concert program of the Time's Arrow performance on Friday, December 8, 2000 at 8:00 p.m., at the Tsai Performance Center, 685 Commonwealth Avenue, Boston, Massachusetts.
School of Music, Boston University
core  

Cosmological wheel or the arrow of time: A classical versus quantum perspective of gravity

open access: yes, 2017
It is shown that the structures in the universe can be interpreted to show a closed wheel of time, rather than a straight arrow. An analysis in $f(R)$ gravity model has been carried out to show that due to local observations a small arc at any given ...
Verma, Murli Manohar, Yadav, Bal Krishna
core   +1 more source

A working model for cytoplasmic assembly of H/ACA snoRNPs

open access: yesFEBS Letters, EarlyView.
Dyskerin is the component of nuclear H/ACA ribonucleoproteins (RNPs) endowed with pseudouridine synthase catalytic activity. Two isoforms of human dyskerin have been characterized: the abundant Iso1, mainly nuclear, and the shorter Iso3, mainly cytoplasmic but occasionally imported into nuclei.
Alberto Angrisani, Maria Furia
wiley   +1 more source

“Current training” in Cardiac devices – a Cardiology trainee perspective: a questionnaire survey

open access: yesMedEdPublish, 2017
A national survey (questionnaire) on Cardiology trainees undertaken on behalf of the author by the British Junior Cardiologists Association (BJCA) on training opportunities, needs, attitudes and perceived barriers that exist within "current training" in ...
Cheuk Wing Jonathan Lee, Archana Rao
doaj  

Mechanistic basis for inhibition of the extended‐spectrum β‐lactamase GES‐1 by enmetazobactam and tazobactam

open access: yesFEBS Letters, EarlyView.
Antimicrobial resistance (AMR) is of huge importance, resulting in over 1 million deaths each year. Here, we describe how a new drug, enmetazobactam, designed to help fight resistant bacterial diseases, inhibits a key enzyme (GES‐1) responsible for AMR. Our data show it is a more potent inhibitor than the related tazobactam, with high‐level computation
Michael Beer   +10 more
wiley   +1 more source

C9orf72 ALS‐causing mutations lead to mislocalization and aggregation of nucleoporin Nup107 into stress granules

open access: yesFEBS Letters, EarlyView.
Mutations in the C9orf72 gene represent the most common genetic cause of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Using patient‐derived neurons and C. elegans models, we find that the nucleoporin Nup107 is dysregulated in C9orf72‐associated ALS. Conversely, reducing Nup107 levels mitigates disease‐related changes.
Saygın Bilican   +7 more
wiley   +1 more source

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