Results 11 to 20 of about 934,191 (255)

Pan-cancer efficacy of pralsetinib in patients with RET fusion–positive solid tumors from the phase 1/2 ARROW trial

open access: yesNature Medicine, 2022
Oncogenic RET fusions occur in diverse cancers. Pralsetinib is a potent, selective inhibitor of RET receptor tyrosine kinase. ARROW (NCT03037385, ongoing) was designed to evaluate pralsetinib efficacy and safety in patients with advanced RET-altered ...
Vivek Subbiah   +2 more
exaly   +2 more sources

Arrow of Causality and Quantum Gravity [PDF]

open access: yesPhysical Review Letters, 2019
Causality in quantum field theory is defined by the vanishing of field commutators for spacelike separations. However, this does not imply a direction for causal effects.
John Francis Donoghue, Gabriel Menezes
exaly   +2 more sources

Time's arrow, time's cycle: Granulite metamorphism and geodynamics

open access: yesMineralogical Magazine, 2019
Although the thermal evolution of the mantle before c. 3.0 Ga remains unclear, since c. 3.0 Ga secular cooling has dominated over heat production—this is time's arrow.
Michael Brown, Te Johnson, Tim Johnson
exaly   +2 more sources

Solid-Phase Microextraction Arrow for the Sampling of Volatile Organic Compounds in Milk Samples

open access: yesSeparations, 2020
A novel sample preparation method based on the use of the Arrow solid-phase microextraction device was used to extract and preconcentrate volatile organic compounds (VOCs) from milk samples prior to their determination by gas chromatography–mass ...
Natalia Manousi   +2 more
doaj   +2 more sources

Decision Making in the Arrow of Time [PDF]

open access: yesPhysical Review Letters, 2015
We show that the steady-state entropy production rate of a stochastic process is inversely proportional to the minimal time needed to decide on the direction of the arrow of time. Here we apply Wald's sequential probability ratio test to optimally decide
Édgar Roldán   +2 more
exaly   +2 more sources

Analyzing volatiles in brown rice vinegar by headspace solid-phase microextraction (SPME)–Arrow: Optimizing the extraction conditions and comparisons with conventional SPME

open access: yesInternational Journal of Food Properties, 2019
The ability to readily determine the composition of brown rice vinegar is important for quality assurance purposes. To that end, solid–phase microextraction (SPME)–Arrow method was optimized for the determination of volatile organic compounds (VOCs) from
Tae Gyu Nam   +4 more
doaj   +2 more sources

PAL SPME Arrow—evaluation of a novel solid-phase microextraction device for freely dissolved PAHs in water

open access: yesAnalytical and Bioanalytical Chemistry, 2015
After more than 25 years, solid-phase microextraction (SPME) has gained widespread acceptance as a well-automatable and flexible microextraction technique, while its instrumental basis remained mostly unchanged.
Maik A Jochmann, Torsten C Schmidt
exaly   +2 more sources

Decomposing the Local Arrow of Time in Interacting Systems. [PDF]

open access: yesPhysical Review Letters, 2021
We show that the evidence for a local arrow of time, which is equivalent to the entropy production in thermodynamic systems, can be decomposed. In a system with many degrees of freedom, there is a term that arises from the irreversible dynamics of the ...
Christopher W. Lynn   +3 more
semanticscholar   +1 more source

Flourishing in critical dialogue

open access: yesSSM - Mental Health, 2023
We discuss various critiques of the research literature on flourishing. We fully agree with calls for greater attention to qualitative work, to cultural differences, and to questions of power and justice concerning flourishing. We argue, however, that in
Tyler J. VanderWeele   +7 more
doaj   +1 more source

ARROW: restoration-aware traffic engineering

open access: yesConference on Applications, Technologies, Architectures, and Protocols for Computer Communication, 2021
Fiber cut events reduce the capacity of wide-area networks (WANs) by several Tbps. In this paper, we revive the lost capacity by reconfiguring the wavelengths from cut fibers into healthy fibers.
Zhizhen Zhong   +5 more
semanticscholar   +1 more source

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