Results 11 to 20 of about 1,939,761 (391)

Pan-cancer efficacy of pralsetinib in patients with RET fusion–positive solid tumors from the phase 1/2 ARROW trial

Nature Medicine, 2022
Oncogenic RET fusions occur in diverse cancers. Pralsetinib is a potent, selective inhibitor of RET receptor tyrosine kinase. ARROW (NCT03037385, ongoing) was designed to evaluate pralsetinib efficacy and safety in patients with advanced RET-altered ...
Vivek Subbiah, Salvatore Siena, Pilar Garrido   +2 more
exaly   +2 more sources

Arrow of Causality and Quantum Gravity [PDF]

Physical Review Letters, 2019
Causality in quantum field theory is defined by the vanishing of field commutators for spacelike separations. However, this does not imply a direction for causal effects.
John Francis Donoghue, Gabriel Menezes
exaly   +2 more sources

Relating the thermodynamic arrow of time to the causal arrow [PDF]

Journal of Statistical Mechanics: Theory and Experiment, 2007
Consider a Hamiltonian system that consists of a slow subsystem S and a fast subsystem F. The autonomous dynamics of S is driven by an effective Hamiltonian, but its thermodynamics is unexpected.
Armen E Allahverdyan, Balian R, Becker R, Berdichevsky V L, Berry M V, Campisi M, Carroll S M Chen J, Carroll S M Chen J, De Roeck W Maes C Netocny K, Dominik Janzing, Gemmer J, Gorban A, Haken H, Hoffding H, Kano Y Shimizu S, Kasuga T, Lichtenberg A J, Lindblad G, Munster A, Pearl J, Penrose O, Reichenbach H, Risken H, Sagdeev R Z, Schulman L S, Schölkopf B, Spirtes P, Sun X Janzing D Schölkopf B, Wald R M, Weiss U, Zeh H D   +30 more
core   +5 more sources

Thermodynamic optimization in laminar and fully developed flow in double pipe heat exchanger with arrow-shaped extended surfaces: A novel design

Case Studies in Thermal Engineering, 2023
An innovative design of extended fins in the form of arrow fins is optimized for high performance heat transfer in a double pipe heat exchanger (DPHX).
Ghazala Ashraf, Sardar Bilal, Muhammad Ishaq, Syed Khalid Saifullah, A.S. Alqahtani, M.Y. Malik   +5 more
doaj   +2 more sources

Decision Making in the Arrow of Time [PDF]

Physical Review Letters, 2015
We show that the steady-state entropy production rate of a stochastic process is inversely proportional to the minimal time needed to decide on the direction of the arrow of time. Here we apply Wald's sequential probability ratio test to optimally decide
Édgar Roldán, Izaak Neri, Meik Dörpinghaus   +2 more
exaly   +2 more sources

Solid-Phase Microextraction Arrow for the Sampling of Volatile Organic Compounds in Milk Samples

Separations, 2020
A novel sample preparation method based on the use of the Arrow solid-phase microextraction device was used to extract and preconcentrate volatile organic compounds (VOCs) from milk samples prior to their determination by gas chromatography–mass ...
Natalia Manousi, Erwin Rosenberg, George A. Zachariadis   +2 more
doaj   +2 more sources

Identification of a Gravitational Arrow of Time [PDF]

Physical Review Letters, 2014
It is widely believed that special initial conditions must be imposed on any time-symmetric law if its solutions are to exhibit behavior of any kind that defines an "arrow of time." We show that this is not so.
Tim Koslowski, Flavio Mercati
exaly   +2 more sources

The length of time's arrow [PDF]

Physical Review Letters, 2008
An unresolved problem in physics is how the thermodynamic arrow of time arises from an underlying time reversible dynamics. We contribute to this issue by developing a measure of time-symmetry breaking, and by using the work fluctuation relations, we ...
A. S. Eddington, Edward H. Feng, Gavin E. Crooks, H. Jeffreys, H. Price, I. J. Taneja, T. M. Cover   +6 more
core   +6 more sources

Is Time's Arrow Perspectival? [PDF]

, 2015
We observe entropy decrease towards the past. Does this imply that in the past the world was in a non-generic microstate? I point out an alternative. The subsystem to which we belong interacts with the universe via a relatively small number of quantities,
Rovelli, Carlo
core   +5 more sources

Analyzing volatiles in brown rice vinegar by headspace solid-phase microextraction (SPME)–Arrow: Optimizing the extraction conditions and comparisons with conventional SPME

International Journal of Food Properties, 2019
The ability to readily determine the composition of brown rice vinegar is important for quality assurance purposes. To that end, solid–phase microextraction (SPME)–Arrow method was optimized for the determination of volatile organic compounds (VOCs) from
Tae Gyu Nam, Jun-Young Lee, Bum-Keun Kim, Nho-Eul Song, Hae Won Jang   +4 more
doaj   +2 more sources