Results 61 to 70 of about 856,080 (316)
A working model for cytoplasmic assembly of H/ACA snoRNPs
FEBS Letters, EarlyView.Dyskerin is the component of nuclear H/ACA ribonucleoproteins (RNPs) endowed with pseudouridine synthase catalytic activity. Two isoforms of human dyskerin have been characterized: the abundant Iso1, mainly nuclear, and the shorter Iso3, mainly cytoplasmic but occasionally imported into nuclei.
Alberto Angrisani, Maria Furia
wiley +1 more source
The Direction of Time: From the Global Arrow to the Local Arrow [PDF]
International Journal of Theoretical Physics, 2003 In this paper we discuss the traditional approaches to the problem of the arrow of time. On the basis of this discussion we adopt a global and non-entropic approach, according to which the arrow of time has a global origin and is an intrinsic, geometrical feature of space-time.
Olimpia Lombardi +2 more
openaire +3 more sources
FEBS Letters, EarlyView.Antimicrobial resistance (AMR) is of huge importance, resulting in over 1 million deaths each year. Here, we describe how a new drug, enmetazobactam, designed to help fight resistant bacterial diseases, inhibits a key enzyme (GES‐1) responsible for AMR. Our data show it is a more potent inhibitor than the related tazobactam, with high‐level computation
Michael Beer +10 more
wiley +1 more source
Solid-Phase Microextraction Arrow for the Sampling of Volatile Organic Compounds in Milk Samples
Separations, 2020 A novel sample preparation method based on the use of the Arrow solid-phase microextraction device was used to extract and preconcentrate volatile organic compounds (VOCs) from milk samples prior to their determination by gas chromatography–mass ...
Natalia Manousi +2 more
doaj +1 more source
FEBS Letters, EarlyView.Mutations in the C9orf72 gene represent the most common genetic cause of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Using patient‐derived neurons and C. elegans models, we find that the nucleoporin Nup107 is dysregulated in C9orf72‐associated ALS. Conversely, reducing Nup107 levels mitigates disease‐related changes.
Saygın Bilican +7 more
wiley +1 more source
Secondary Students’ Perceptions of Open Science Textbooks
Journal of Interactive Media in Education, 2018 In an attempt to align instructional resources with new state standards and to increase teacher awareness of these standards, one large suburban public school district piloted the development and adoption of open secondary science textbooks.
Rebecca Morales, Alesha Baker
doaj +1 more source
Novel and unscrutinized immune entities of the zebrafish gut
FEBS Letters, EarlyView.Understudied cells of the zebrafish immune system include bona fide immune cells and epithelial (‐derived) cells with immune functions. Research focusing on zebrafish cells which demonstrate similarities to mammalian immune cell counterparts may help us understand the pathologies in which they are implicated. Currently available and advanced tools make
Audrey Inge Schytz Andersen‐Civil +5 more
wiley +1 more source
FEBS Letters, EarlyView.Single‐cell RNA sequencing reveals an opposite role of SLPI in basal tumors based on metastatic spread, along with shared activation of specific regulons in cancer cells and mature luminal lactocytes, as well as downregulation of MALAT1 and NEAT1 in the latter.
Pietro Ancona +4 more
wiley +1 more source
Sabot Front Borerider Stiffness vs. Dispersion: Finding the Knee in the Curve
Shock and Vibration, 2001 In the design of armor piercing, fin-stabilized, discarding sabot projectiles, the radial stiffness of the sabot front borerider has a significant impact on the projectile's dispersion and is, therefore, an important design consideration.
Alan F. Hathaway, John R. Burnett Jr.
doaj +1 more source
LA SIMPATÍA EXTENDIDA Y LA POSIBILIDAD DE LA ELECCIÓN SOCIAL
Stoa, 2014 La meta de este artículo es examinar diferentes principios de elección social, con diferentes implicaciones para la justicia social, así como sus invariancias e interrelaciones lógicas.
Kenneth J. Arrow
doaj +1 more source