Results 61 to 70 of about 1,758,752 (301)
Vacuum Structure and the Arrow of Time
, 2012 We find ourselves in an extended era of entropy production. Unlike most other observations, the arrow of time is usually regarded as a constraint on initial conditions. I argue, however, that it primarily constrains the vacuum structure of the theory.
A. Linde +4 more
core +2 more sources
FEBS Letters, EarlyView.Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma +8 more
wiley +1 more source
Multi-Level Languages are Generalized Arrows [PDF]
arXiv, 2010 Multi-level languages and Arrows both facilitate metaprogramming, the act of writing a program which generates a program. The arr function required of all Arrows turns arbitrary host language expressions into guest language expressions; because of this, Arrows may be used for metaprogramming only when the guest language is a superset of the host ...
arxiv
Revisiting the Origin of the Universe and the Arrow of Time [PDF]
arXiv, 2021 We reconsider the old but yet unsolved problems, origin of the universe and the arrow of time. We show that only the closed universe is free from the singularity with the arrow of time symmetric with respect to the maximal size of the cosmic scale. The Wheeler-DeWitt equation is explicitly solved to obtain the local dynamical times.
arxiv
Identification of novel small molecule inhibitors of ETS transcription factors
FEBS Letters, EarlyView.ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla +9 more
wiley +1 more source
arXiv, 2023 In this paper we introduce arrow algebras, simple algebraic structures which induce elementary toposes through the tripos-to-topos construction. This includes localic toposes as well as various realizability toposes, in particular, those realizability toposes which are obtained from partial combinatory algebras.
arxiv
The Saccharomyces cerevisiae amino acid transporter Lyp1 has a broad substrate spectrum
FEBS Letters, EarlyView.In Saccharomyces cerevisiae, Yeast Amino acid Transporter family members mediate the import of amino acids, ranging from substrate specialists to generalists. Here, we show that the specialist transporter, Lyp1, has a broader substrate spectrum than previously described, with affinity constants spanning from micromolar to millimolar.
Foteini Karapanagioti +3 more
wiley +1 more source
Cosmological arrow of time in f(R) gravity [PDF]
arXiv, 2016 The cosmological arrow of time may be linked to the thermodynamic arrow by second law of thermodynamics. The time asymmetry is also associated with dissipative fluid as Tolman introduced a viscous fluid to generate an arrow of time in cyclic cosmology.
arxiv
FEBS Letters, EarlyView.In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley +1 more source
The Arrow of Time in Rigged Hilbert Space Quantum Mechanics [PDF]
arXiv, 2005 Arno Bohm and Ilya Prigogine's Brussels-Austin Group have been working on the quantum mechanical arrow of time and irreversibility in rigged Hilbert space quantum mechanics. A crucial notion in Bohm's approach is the so-called preparation/registration arrow. An analysis of this arrow and its role in Bohm's theory of scattering is given.
arxiv