Results 71 to 80 of about 1,835,390 (328)
Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia
FEBS Letters, EarlyView.This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley +1 more source
Solid-Phase Microextraction Arrow for the Sampling of Volatile Organic Compounds in Milk Samples
Separations, 2020 A novel sample preparation method based on the use of the Arrow solid-phase microextraction device was used to extract and preconcentrate volatile organic compounds (VOCs) from milk samples prior to their determination by gas chromatography–mass ...
Natalia Manousi +2 more
doaj +1 more source
Arbitrary Arrow Update Logic with Common Knowledge is neither RE nor co-RE [PDF]
Electronic Proceedings in Theoretical Computer Science, 2017 Arbitrary Arrow Update Logic with Common Knowledge (AAULC) is a dynamic epistemic logic with (i) an arrow update operator, which represents a particular type of information change and (ii) an arbitrary arrow update operator, which quantifies over arrow ...
Louwe B. Kuijer
doaj +1 more source
The Musical Times and Singing Class Circular, 1886 n ...
Longfellow,, Gounod, C.-H.
openaire +2 more sources
Making tau amyloid models in vitro: a crucial and underestimated challenge
FEBS Letters, EarlyView.This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley +1 more source
Vacuum Structure and the Arrow of Time
, 2012 We find ourselves in an extended era of entropy production. Unlike most other observations, the arrow of time is usually regarded as a constraint on initial conditions. I argue, however, that it primarily constrains the vacuum structure of the theory.
A. Linde +4 more
core +2 more sources
The arrow of time and the nature of spacetime [PDF]
, 2013 This paper extends the work of a previous paper [arXiv:1208.2611] on the flow of time, to consider the origin of the arrow of time. It proposes that a `past condition' cascades down from cosmological to micro scales, being realized in many ...
Ellis, George F R
core +1 more source
FEBS Letters, EarlyView.Toll‐like receptors (TLRs) are important in the innate immune system. This study explores the zinc‐binding ability of the TLR2 TIR domain (TLR2TIR). We found that TLR2TIR binds zinc with nanomolar affinity through its cysteine residues. Two of them, C673 and C713, are vital for receptor activation, indicating that zinc may play a role in initiating ...
Vladislav A. Lushpa +8 more
wiley +1 more source
The hidden arrow in the FedEx logo: Do we really unconsciously “see” it?
Cognitive Research, 2023 The FedEx logo makes clever use of figure-ground ambiguity to create an “invisible” arrow in the background space between “E” and “x”. Most designers believe the hidden arrow can convey an unconscious impression of speed and precision about the FedEx ...
Shih-Chiang Ke +4 more
doaj +1 more source
FEBS Letters, EarlyView.In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley +1 more source