Results 121 to 130 of about 3,334,012 (298)

Impact of molecular diagnostics and targeted cancer therapy on patient outcomes (MODIFY): a retrospective study of the implementation of precision oncology

open access: yesMolecular Oncology, EarlyView.
The authors conducted a retrospective study of 94 patients with advanced cancer who underwent next‐generation sequencing (NGS) gene panel analysis and received targeted treatments when applicable. Results further support evidence indicating that molecular profiling provides clinical benefit.
Michaël Dang   +3 more
wiley   +1 more source

The Time's Arrow within the Uncertainty Quantum [PDF]

open access: yesarXiv, 1998
A generalized framework is developed which uses a set description instead of wavefunction to emphasize the role of the observer. Such a framework is found to be very effective in the study of the measurement problem and time's arrow. Measurement in classical and quantum theory is given a unified treatment.
arxiv  

Detection rate for ESR1 mutations is higher in circulating‐tumor‐cell‐derived genomic DNA than in paired plasma cell‐free DNA samples as revealed by ddPCR

open access: yesMolecular Oncology, EarlyView.
Analysis of ESR1 mutations in plasma cell‐free DNA (cfDNA) is highly important for the selection of treatment in patients with breast cancer. Using multiplex‐ddPCR and identical blood draws, we investigated whether circulating tumor cells (CTCs) and cfDNA provide similar or complementary information for ESR1 mutations.
Stavroula Smilkou   +11 more
wiley   +1 more source

Information and the arrow of time [PDF]

open access: yesarXiv, 2011
This paper is a discussion about the relationship between time and information. We argue that the direction of arrow of time is related to the directivity of information copying that occurs in Nature.
arxiv  

Robust acute myeloid leukemia engraftment in humanized scaffolds using injectable biomaterials and intravenous xenotransplantation

open access: yesMolecular Oncology, EarlyView.
Patient‐derived xenografts (PDXs) can be improved by implantation of a humanized niche. We tested different biomaterials and approaches, and demonstrate that the combination of an injectable biomaterial for scaffold creation plus an intravenous route for acute myeloid leukemia (AML) xenotransplantation provide the most convenient and robust approach to
Daniel Busa   +13 more
wiley   +1 more source

Growth of Knowledge and Entropy in Quantum Physics [PDF]

open access: yesarXiv, 2008
Most attempts to argue for the second law of thermodynamics fail because (1) they use the unviable frequency theory of probability and (2) they do not explain why the arrow of time seen in experiments is aligned with the thermodynamic arrow of time. I use the decision theoretic interpretation of quantum probability from the many worlds interpretation ...
arxiv  

KMT2A degradation is observed in decitabine‐responsive acute lymphoblastic leukemia cells

open access: yesMolecular Oncology, EarlyView.
We demonstrate that decitabine (DEC) not only degrades the DNA methyltransferase DNMT1 but also the leukemic driver lysine methyltransferase KMT2A likely due to structural similarity of the DNA‐binding CXXC domains. DEC influences KMT2A downstream processes and synergizes with menin inhibitor revumenib (REV) to decrease leukemic cell proliferation, and
Luisa Brock   +10 more
wiley   +1 more source

The arrow of time: Advancing insights into action control from the arrow version of the Eriksen flanker task. [PDF]

open access: yesAtten Percept Psychophys, 2021
Ridderinkhof KR   +4 more
europepmc   +1 more source

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