Results 81 to 90 of about 716,442 (251)
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
SSRN Electronic JournalScientific discussions of the arrow of time often get quite confusing due to highly complex systems they deal with. Popular literature then often coveys messages that tend to get lost in translation. The purpose of this note is to demystify the arrow of time by stripping off the unnecessary complexities and thereby simplifying the discussion.
openaire +2 more sources
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Does time exist in quantum gravity?
Zagadnienia Filozoficzne w Nauce, 2015 Time is absolute in standard quantum theory and dynamical in general relativity. The combination of both theories into a theory of quantum gravity leads therefore to a “problem of time”.
Claus Kiefer
doaj
A Review of the Concept of Time Reversal and the Direction of Time
Entropy: In the debate about the direction of time in physics, the concept of time reversal has been central. Tradition has it that time-reversal invariant laws are sufficient to state that the direction of time is non-fundamental or emergent. In this paper, we
Cristian López, Olimpia Lombardi
doaj +1 more source
FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
The Arrow of Time: Challenges for Sociological Knowledge
Социологическая наука и социальная практика, 2014 The author analyzes new challenges appeared as a result of the becoming of the complex socium. It is shown that these vulnerabilities manifest new risks for the functioning of the society and its members.
Sergey A. Kravchenko
doaj
Astronomy and Geophysics, 1971 If we are unfortunate enough to drop a basket of eggs we may rightly feel dismayed. For even with the most painstaking human manipulation it is surely not possible to reassemble the broken pieces.
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Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source