Results 41 to 50 of about 576,496 (275)
Polypharmacy to Mitigate Acute and Delayed Radiation Syndromes
Frontiers in Pharmacology, 2021 There is a need for countermeasures to mitigate lethal acute radiation syndrome (ARS) and delayed effects of acute radiation exposure (DEARE). In WAG/RijCmcr rats, ARS occurs by 30-days following total body irradiation (TBI), and manifests as potentially
Tracy Gasperetti +16 more
doaj +1 more source
Sub-Surface Meridional flow, Vorticity and the life time of Solar Active Regions
, 2010 Solar sub-surface fluid topology provides an indirect approach to examine the internal characteristics of active regions (ARs). Earlier studies have revealed the prevalence of strong flows in the interior of ARs having complex magnetic fields.
Ambastha +23 more
core +1 more source
FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source
Genesis Locations of the Costliest Atmospheric Rivers Impacting the Western United States
Geophysical Research Letters, 2021 Atmospheric rivers (ARs) are responsible for the vast majority (∼88%) of flood damage in the Western U.S., an annual average of USD$1.1 billion. Here, using historical flood insurance data, we investigate the genesis characteristics of damaging ARs in ...
Hamish D. Prince +7 more
doaj +1 more source
Frontiers in Pharmacology, 2022 The KRAS-G12C inhibitor ARS-1620, is a novel specific covalent inhibitor of KRAS-G12C, possessing a strong targeting inhibitory effect on KRAS-G12C mutant tumors.
Xing-Duo Dong +11 more
doaj +1 more source
Fish assemblages associated with three types of artificial reefs: density of assemblages and possible impacts on adjacent fish abundance [PDF]
, 2010 We evaluated the effectiveness of wooden artificial reefs (ARs) as fish habitat. Three types of ARs, made of cedar logs, broadleaf tree logs, and PVC pipes, respectively, were deployed in triplicate at 8-m depth off Maizuru, Kyoto Prefecture, Sea of ...
Kai, Yoshiaki +7 more
core
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
CALL: Prix Ars Electronica u19 – create your world
Medienimpulse, 2019 Der Wettbewerb für junge Neu-, Quer- und WeiterdenkerInnen. Für alle Young Creatives (0 – 14 Jahre) und Young Professionals (14 – 19 Jahre) in Österreich: Ab sofort kann ganzjährig eingereicht werden!
Katharina Kaiser-Müller
doaj
Recessive aminoacyl-tRNA synthetase disorders: lessons learned from in vivo disease models
Frontiers in Neuroscience, 2023 Protein synthesis is a fundamental process that underpins almost every aspect of cellular functioning. Intriguingly, despite their common function, recessive mutations in aminoacyl-tRNA synthetases (ARSs), the family of enzymes that pair tRNA molecules ...
Elizabeth Kalotay +4 more
doaj +1 more source
Variations in p-mode Parameters and Sub-surface Flows of Active Regions with Flare Activity [PDF]
, 2011 We examine the characteristic properties of photospheric p-modes and sub-photospheric flows of active regions (ARs) observed during the period of 26-31 October 2003.
Ambastha, A., Maurya, R. A.
core