Results 41 to 50 of about 169,738 (259)
Polypharmacy to Mitigate Acute and Delayed Radiation Syndromes
Frontiers in Pharmacology, 2021 There is a need for countermeasures to mitigate lethal acute radiation syndrome (ARS) and delayed effects of acute radiation exposure (DEARE). In WAG/RijCmcr rats, ARS occurs by 30-days following total body irradiation (TBI), and manifests as potentially
Tracy Gasperetti +16 more
doaj +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Recessive aminoacyl-tRNA synthetase disorders: lessons learned from in vivo disease models
Frontiers in Neuroscience, 2023 Protein synthesis is a fundamental process that underpins almost every aspect of cellular functioning. Intriguingly, despite their common function, recessive mutations in aminoacyl-tRNA synthetases (ARSs), the family of enzymes that pair tRNA molecules ...
Elizabeth Kalotay +4 more
doaj +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
Genesis Locations of the Costliest Atmospheric Rivers Impacting the Western United States
Geophysical Research Letters, 2021 Atmospheric rivers (ARs) are responsible for the vast majority (∼88%) of flood damage in the Western U.S., an annual average of USD$1.1 billion. Here, using historical flood insurance data, we investigate the genesis characteristics of damaging ARs in ...
Hamish D. Prince +7 more
doaj +1 more source
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
USDA-ARS-FAESRU 14Jul2017 Salmonella enterica sequencing
, 2021 Salmonella isolates were recovered from mink feces and feed samples from a mink farm in the United ...
USDA-ARS (17854919)
core
, 2015 Esta publicación se realiza con motivo de la exposición titulada Ars-Herbaria celebrada en el Real Jardín Botánico de Madrid del 26 de marzo al 12 de abril de 2015.
Muñon, Jesús +15 more
core +1 more source
Dictynna, 2010 La compétition artistique entre Pallas et Arachné au livre VI des Métamorphoses oppose une déesse, qui représente l’auguste noblesse divine (augusta grauitas), à une tisserande d’origine sociale fort modeste – précise Ovide – mais que son art a rendue ...
Florence Klein
doaj