Results 71 to 80 of about 619,883 (320)

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Sub-Surface Meridional flow, Vorticity and the life time of Solar Active Regions

, 2010
Solar sub-surface fluid topology provides an indirect approach to examine the internal characteristics of active regions (ARs). Earlier studies have revealed the prevalence of strong flows in the interior of ARs having complex magnetic fields.
Ambastha, Basu, Basu, Beck, Braun, Cattaneo, Corbard, Couvidat, Haber, Hill, Hindman, Howe, Jouve, Komm, Komm, Komm, Leibacher, Mason, Maurya, Nordlund, Pevtsov, Rast, Rieutord, Zhao   +23 more
core   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

K-PAM: a unified platform to distinguish Klebsiella species K- and O-antigen types, model antigen structures and identify hypervirulent strains

Scientific Reports, 2020
A computational method has been developed to distinguish the Klebsiella species serotypes to aid in outbreak surveillance. A reliability score (estimated based on the accuracy of a specific K-type prediction against the dataset of 141 distinct K-types ...
L. Ponoop Prasad Patro, Karpagam Uma Sudhakar, Thenmalarchelvi Rathinavelan   +2 more
doaj   +1 more source

Long-period oscillations of active region patterns: least-squares mapping on second-order curves

, 2016
Active regions (ARs) are the main sources of variety in solar dynamic events. Automated detection and identification tools need to be developed for solar features for a deeper understanding of the solar cycle.
De Causmaecker, P., Dumbadze, G., Gurgenashvili, E., Khodachenko, M., Kukhianidze, V., Poedts, S., Ramishvili, G., Shergelashvili, B. M., Zaqarashvili, T. V.   +8 more
core   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Une réponse ovidienne à Asclépiade ? Hypothèse d’une allusion à l’épigramme sur la Lydé d’Antimaque (AP IX, 63) dans le certamen de Pallas et Arachné (Met. VI)

Dictynna, 2010
La compétition artistique entre Pallas et Arachné au livre VI des Métamorphoses oppose une déesse, qui représente l’auguste noblesse divine (augusta grauitas), à une tisserande d’origine sociale fort modeste – précise Ovide – mais que son art a rendue ...
Florence Klein
doaj  

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

III Congreso de Ingeniería de tejidos y medicina regenerativa

ARS Medica
El Congreso de Ingeniería de Tejidos y Medicina Regenerativa (ITMR) es un encuentro bianual que busca reunir a la comunidad científica e instituciones públicas y privadas en torno a las temáticas de ingeniería de tejidos, biomateriales, medicina ...
ARS MEDICA
doaj   +1 more source

Ars Memorativa, Ars Oblivionis in Middle English Religious Plays

American, British and Canadian Studies Journal, 2015
This paper investigates the multi-layered violence of religious representation in the late medieval York biblical plays, with a focus on the Supper at Emmaus.
Ciobanu Estella Antoaneta
doaj   +1 more source