Results 51 to 60 of about 865,296 (337)

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Integration of Narrative Therapy with Expressive Art Practices

Psikiyatride Güncel Yaklaşımlar, 2021
The purpose of this research is to provide information about what is narrative therapy and how expressive art practices can integrate into narrative therapy. Since the nature of narrative therapy’s structure is suitable for integration with art practices,
Şule Baştemur, Esra Baş
doaj   +1 more source

Diagnosis and management of antiretroviral-therapy failure in resource-limited settings in sub-Saharan Africa: challenges and perspectives. [PDF]

, 2010
Despite the enormous progress made in scaling up antiretroviral therapy (ART) in sub-Saharan Africa, many challenges remain, not least of which are the identification and management of patients who have failed first-line therapy. Less than 3% of patients
Akileswaran, Andreas Jahn, Anthony D Harries, Badri, Bierman, Boulle, Boulle, Colebunders, Elliott, Erik J Schouten, Ferradini, Gazzard, Gupta, Hammer, Harries, Harries, Hosseinipour, Joep J van Oosterhout, Johannessen, Johnson, Kamya, Kantor, Keiser, Kelita Kamoto, Kitahata, Kouanfack, Kuhn, Lawn, Lawn, Ledergerber, Libamba, Lockman, Maldonado, Mee, Mills, Mina C Hosseinipour, Moore, Mwaba, Orrell, Phillips, Pujades-Rodriguez, Reynolds, Rony Zachariah, Samb, Sawe, Steven D Reid, Swindells, Tuboi, Uy, van Oosterhout, Vic Arendt, Walmsley, Weiser, Wester, Wilson, Yu, Zachariah, Zengani Chirwa   +57 more
core   +2 more sources

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Low uptake of antiretroviral therapy after admission with human immunodeficiency virus and tuberculosis in KwaZulu-Natal, South Africa. [PDF]

, 2010
A prospective cohort study was conducted among human immunodeficiency virus (HIV) infected in-patients with tuberculosis (TB) or other opportunistic infections (OIs) in South Africa to estimate subsequent antiretroviral therapy (ART) uptake and ...
Kappagoda, S, Kuritzkes, D R, Maphasa, K T M, Murphy, R A, Smeaton, L, Sunpath, H, Taha, B   +6 more
core   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

A comparative study between a transscleral sustained-release device and eyedrops on intraocular distribution of carteolol hydrochloride

Heliyon, 2023
The objectives of this study were to develop a sustained-release device for carteolol hydrochloride (CH) and investigate any potential difference in the intraocular distribution of this agent between the transscleral administration of the device and ...
Yoshiko Hashikawa, Yuki Kato, Hirokazu Kaji, Toshiaki Abe, Nobuhiro Nagai   +4 more
doaj   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein

FEBS Open Bio, EarlyView.
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley   +1 more source

Exploring the relationships between personality and color preferences

Frontiers in Psychology, 2022
IntroductionThis study set out to quantitatively examine the relationship between personality and color, focusing on connotations and preference.MethodA total of 854 Koreans, aged from 20 to 60, participated in the study. They indicated which colors they
Juliet Jue, Jung Hee Ha
doaj   +1 more source