Results 241 to 250 of about 15,257 (261)
Some of the next articles are maybe not open access.
An Update on Artemisinin Resistance
2019While the precise mode of action of artemisinin (ART) derivatives remains obscure, it is nonetheless commonly accepted that ART generates reactive oxygen intermediates that contribute to cell death. Also, numerous studies confirm that point mutations in the propeller domain of K13 protein play a key role in resistance to ART derivatives. Because of its
Ariey, Frederic, Ménard, Didier
openaire +3 more sources
Artemisinins and immune system
European Journal of Pharmacology, 2011Artemisinins in combination with other antimalarial drugs remain the mainstay of current antimalarial armamentarium. It is interesting to note that many traditional drugs with antiprotozoal background can wield immunomodulation on the recipient's immune system in a positive or negative direction. Artemisinins also attribute immunomodulatory distensions.
Lubna, Shakir +4 more
openaire +2 more sources
A Concise Synthesis of (+)-Artemisinin
Journal of the American Chemical Society, 2012Malaria represents one of the most medically and economically debilitating diseases present in the world today. Fortunately, there exists a highly effective treatment based on the natural product artemisinin. Despite the development of several synthetic approaches to the natural product, a streamlined synthesis that utilizes low-cost chemical inputs ...
Chunyin, Zhu, Silas P, Cook
openaire +2 more sources
Artemisinins: Artemisinin, Dihydroartemisinin, Artemether and Artesunate
2011Artemisinin comes from the plant, Artemisia annua, an ancient Chinese herbal remedy for relapsing fever. Rediscovery of its antimalarial action in China in the 1970s has seen it and its semisynthetic derivatives become the most useful drugs for most malarial illness. Artemisinins have a sesquiterpene lactone structure.
openaire +1 more source
Synthesis of Artemisinin G from Artemisinin via Photocatalysis
European Journal of Organic ChemistryAbstractPhotoredox catalysis has become a mainstay in synthetic methodology over the past decade. However, its application in the functionalization of natural products remains to be further explored. Herein, we report an efficient approach to synthesize artemisinin G from artemisinin via photocatalysis in high yield.
Menghan Wang +5 more
openaire +1 more source