Results 221 to 230 of about 181,515 (271)

sGC stimulator BAY 41‐8543 improves survival and ventricular function in a rat model of doxorubicin‐induced cardiomyopathy with nephrotic syndrome

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Anthracyclines such as doxorubicin (DOXO) remain a cornerstone of cancer therapy but are associated with a high risk of cardiotoxicity and subsequent heart failure (HF). Impairment of NO/soluble guanylyl cyclase (sGC)/cGMP pathway has been reported in anthracycline‐induced cardiomyopathy.
Olga Gawrys, Petra Škaroupková, Soňa Kikerlová, Zdeňka Vaňourková, Martina Hüttl, Olga Lenčová, Kasin Yadunandam Anandam, Svenja Stomberg, Sönke Behrends, Barbara Szeiffová Bačová, Matúš Sykora, Lisa Dietz, Peter Sandner, Luděk Červenka, Martin Štěrba   +14 more
wiley   +1 more source

Transgluteal vs. Anterior and Posterior Approaches for Porcine Model of Irreparable Acetabular Labral Tear: A Comparative Study on Feasibility and Safety. [PDF]

Biomed Res Int
Dai W, Su T, Yang L, Chen X, Deng S, Chen G.   +5 more
europepmc   +1 more source

Emerging insights into amino acid metabolism in the heart: implications for cardiovascular diseases and therapeutic targeting

British Journal of Pharmacology, EarlyView.
As a metabolically versatile organ, the heart is capable of generating energy from a wide range of substrates. Although fatty acid and glucose metabolism in the heart have been extensively studied, the contribution of amino acid metabolism to cardiac physiology and disease is gaining increasing attention.
Tayyiba Azam, Hongyuan Zhang, Min Zi, Chen Chen, Junfang Wu, Andreas Papapetropoulos, Xin Wang   +6 more
wiley   +1 more source

Lifestyle Management in Menopause: A Systematic Review of Women With Premature Ovarian Insufficiency

Clinical Endocrinology, EarlyView.
ABSTRACT Objective Premature ovarian insufficiency (POI), the loss of ovarian function before age 40, increases the risk of cardiovascular disease, low bone mineral density, dementia and psychological distress. Lifestyle interventions reduce chronic disease risk in other populations and, with hormone therapy, may improve health outcomes in POI.
Ladan Yeganeh, Nathalie Vermeulen, Carolyn Ee, Helena Teede, Amanda J. Vincent   +4 more
wiley   +1 more source

Management strategies for acute type A aortic dissection during pregnancy: a single-center retrospective experience. [PDF]

BMC Pregnancy Childbirth
Xu Y, Xia YH, Bai ZM, Dai XF.
europepmc   +1 more source

Mosaic KRAS Variant as a Cause of Developmental Eye Anomalies in an Individual With EncephaloCranioCutaneous Lipomatosis

Clinical Genetics, EarlyView.
We describe a girl presenting with structural eye anomalies and a constellation of features suggestive of the mosaic RASopathy EncephaloCranioCutaneous Lipomatosis (ECCL). Tissue‐specific investigations identified a mosaic KRAS variant at a mutational hotspot (p.[Ala146Pro]), prompting appropriate tumour surveillance.
Karthikah Jeganathan, Fabiola Ceroni, Samuel J. H. Clokie, Nicole Motton Hill, Manoj Parulekar, Karl Johnson, Lidiya V. Talbot, Dorine A. Bax, Nicola K. Ragge   +8 more
wiley   +1 more source

Treatment of aortic arch and left subclavian artery aneurysms in two stages using combined surgical approaches: case report. [PDF]

J Vasc Bras
Der Wu JS, Dias LPM, Volpiani GG, Castelli V, Dos Santos VP, Nogueira LEMP, Bernardi WH, Caffaro RA.   +7 more
europepmc   +1 more source

3D‐Printed Bioadhesive Interfaces as Proliferative Niches for Tissue Repair

Cell Proliferation, EarlyView.
3D printing transforms bioadhesives into structured, multifunctional interfaces that coordinate adhesion, mechanics, transport and biofunctional signalling and may thereby enable proliferative‐niche formation. Qualifying interfaces support cell survival, context‐appropriate proliferation and constructive remodelling advancing tissue repair towards ...
Zhen Gu, Xinyong Su, Guoshi Xu, Yongqiang Wen, Qi Gu   +4 more
wiley   +1 more source

Acute cardiorenal decompensation in the setting of chronic renal artery stenosis treated with successful renal artery stenting. A case report. [PDF]

Arch Peru Cardiol Cir Cardiovasc
Ahmed N, Arriola-Montenegro J, Rashid S, McPhail IR, Bizer B, Craici IM, Riad SM.   +6 more
europepmc   +1 more source

MD‐1 Deficiency Mitigates Atherosclerosis by Inhibiting NLRP3 Inflammasome Activation via cGAS‐STING Dependent Pathway in Macrophages

Cell Proliferation, EarlyView.
MD‐1 is induced and activated in macrophages. The activated MD‐1 subsequently promotes the cGAS‐STING‐TBK1‐IRF3 signalling pathway to activate the NLRP3 inflammasome, and subsequently increases pro‐inflammatory macrophage polarisation and decreases plaque stability to accelerate the development of atherosclerosis.
Fang Zhao, Zhili Jin, Zhiwei Cai, Quan Zhang, Tao He, Xiangjie Kong, Ming Chen, Zhibing Lu, Xiaorong Hu, Wen‐Lin Cheng   +9 more
wiley   +1 more source