Results 61 to 70 of about 181,515 (271)

Proximal femoral focal deficiency : a case report [PDF]

, 2008
Proximal Femoral Focal Deficiency (PFFD) is a rare and complex congenital anomaly (1:50,000-200,000 population) that results in varying degrees of femoral hypoplasia with limb shortening and pelvic abnormalities.
Ellul, Marthese, Grixti, Charles J., Chircop, Marcelle, Grech, Victor E.   +3 more
core  

NCLX Inhibition plus Ca2+ Delivery Potentiates Electroporation and Antitumor Immunity in Pancreatic Ductal Adenocarcinoma

Advanced Science, EarlyView.
Electroporation combined with NCLX inhibition and Ca2+ delivery induces mitochondrial Ca2+ overload in PDAC cells, triggering pyroptosis, DAMP release, and antitumor immune activation. Simultaneously, suppression of tumor‐derived SPP1 weakens SPP1–CD44 signaling and remodels macrophages toward an antitumor phenotype, thereby enhancing CD8+ T‐cell ...
Chuanbing Zhao, Long He, Yu Lu, Zanglong Deng, Hongzhen Wei, Yunpeng Zhang, Ming Yang, Tao Yin   +7 more
wiley   +1 more source

Aneurisma de artéria isquiática persistente: relato de caso Persistent sciatic artery aneurysm: case report

Jornal Vascular Brasileiro, 2008
Os autores relatam um caso de aneurisma de artéria isquiática persistente, uma rara doença vascular congênita ocasionada por falha ou no desenvolvimento do sistema femoral ou na involução do tronco vascular primitivo durante o desenvolvimento ...
José Lacerda Brasileiro, Juliana Chen, Maldonat Azambuja Santos   +2 more
doaj   +1 more source

Thioredoxin‐2 Alleviates Osteoporosis by Restraining FOXO3a Nuclear Translocation

Advanced Science, EarlyView.
Endothelial TRX2 preserves bone homeostasis by retaining FOXO3a at mitochondria and limiting TRAIL production. Loss of TRX2 or oxidative stress releases FOXO3a for nuclear translocation, increasing endothelial TRAIL secretion and driving osteoclast formation and bone loss.
Chi Zhan, Zhaocai Zhou, Yue Ding, Rong Lian, Xinyu Li, Xintong Zhang, Jie Cao, Zhonghui Tang, Zhengmei Lin, Zhi Song, Feng He   +10 more
wiley   +1 more source

Vascularização temporária de membros isquêmicos por meio de shunt arteriomedular: trabalho experimental Temporary vascularization on ischemic limbs through arterial-medullar shunt: an experimental work

Jornal Vascular Brasileiro, 2012
CONTEXTO: Os autores idealizaram um shunt temporário entre a artéria femoral e o canal medular de ossos longos para manter a viabilidade dos membros agudamente isquêmicos, enquanto não é possível estabelecer um tratamento definitivo.
Ronaldo André Poerschke, Daniela Augustin Silveira, Peterson Lodi, Wagner Titton, Guilherme Marx, Alexandre Soares Lampert   +5 more
doaj   +1 more source

Lactate Homeostasis Disruption Potentiates TACE‐Immunotherapy in Hepatocellular Carcinoma

Advanced Science, EarlyView.
Lactate homeostasis is disrupted through spatially coordinated extracellular neutralization and intracellular acidification, triggering calcium overload, mitochondrial dysfunction, and immunogenic cell death. This metabolic reprogramming alleviates the immunosuppressive tumor microenvironment and enhances immune checkpoint blockade, providing a ...
Minjiang Chen, Xiaoxiao Chen, Baozhu Yang, Hui Xu, Xueting Sun, Hongkai Qi, Huilin Hu, Ronghua Wu, Fengkai Qiu, Bing Wu, Yu Luo, Gaofeng Shu, Jiansong Ji   +12 more
wiley   +1 more source

Pseudoaneurisma de arteria femoral asociado a fístula arteriovenosa producido por tornillo de bloqueo distal

Revista chilena de radiología, 2017
El pseudoaneurisma de arteria femoral asociado a fístula arteriovenosa es una complicación de los procedimientos intervencionistas endovasculares. Sin embargo, no se han descrito casos en los que ambas lesiones se produzcan como consecuencia de cirugía traumatológica y, en concreto, que sean secundarias a la colocación de clavo gamma en fémur con ...
Cozcolluela C, M. Rosa, Díaz de Rada L, Pablo, Zalazar, Laura, Ibáñez M, David, Yanguas B, Nerea, Insausti G, Iñigo   +5 more
openaire   +2 more sources

ALDH2 Deficiency Promotes Mitochondrial Oxidative Stress and Adverse Limb Outcomes via VDAC–HSP60 Signaling

Advanced Science, EarlyView.
ALDH2 deficiency promotes 4‐HNE accumulation, resulting in covalent modification of HSP60, disruption of its oligomeric assembly, and VDAC1‐dependent release of HSP60 from mitochondria to the cytosol. Pharmacological activation of ALDH2 preserves HSP60 proteostasis and mitochondrial integrity, whereas the clinical association between the ALDH2 rs671 ...
You‐Cheng Lin, Nan‐Chun Wu, Chon‐Seng Hong, Po‐Chao Hsu, Wen‐Jin Yang, Yi‐Cheng Chang, Che‐Hong Chen, Wei‐Ting Chang   +7 more
wiley   +1 more source

Interação entre as vias de sinalização de receptores serotoninérgicos e Β-adrenérgicos em artéria femoral de ratos Interacción entre las vías de señalización de receptores serotoninérgicos y β-adrenégicos en la arteria femoral de ratones Interaction between serotoninergic-and β-adrenergic receptors signaling pathways in rat femoral artery

Arquivos Brasileiros de Cardiologia, 2012
FUNDAMENTO: A doença coronária tem sido amplamente estudada em pesquisas cardiovasculares. No entanto, pacientes com doença arterial periférica (DAP) têm piores resultados em comparação àqueles com doença arterial coronariana.
Maria Andréia Delbin, Alexandre Sérgio Silva, Edson Antunes, Angelina Zanesco   +3 more
doaj  

Irrigación y conformación fascicular del nervio femoral en el perro [PDF]

, 2009
El objetivo del trabajo fue determinar el origen y distribución segmentaria de los vasos sanguíneos queconstituyen el sistema extrínseco de vascularización e identificar el número y situación delos fascículos que conforman el nervio femoral en el perro ...
Cabrera, W. R., Baéz, A. D., Flores Quintana, Carolina Isabel, Llano, Eduardo G., Cabrera, Walter Ramón, Llano, Eduardo Gabriel, Llano, E. G., Flores Quintana, C. I., Báez, Alejandro Daniel   +8 more
core   +1 more source