Results 41 to 50 of about 1,129,912 (308)

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Accelerated Vascular Aging as a Possible Mechanism of Troponin I Release in the Absence of Clinically Manifested Myocardial Injury

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background We examined the association between clusters of vascular aging manifestations and ultrasensitivity cardiac troponin I in individuals without cardiovascular disease.
G. A. Alanis, P. Boutouyrie, M. Abouqateb, R. M. Bruno, M. Andrieu, B. Vedie, D. Geromin, N. Danchin, S. Laurent, X. Jouven, J. P. Empana   +10 more
doaj   +1 more source

Functional optimization of the arterial network [PDF]

, 2014
We build an evolutionary scenario that explains how some crucial physiological constraints in the arterial network of mammals - i.e. hematocrit, vessels diameters and arterial pressure drops - could have been selected by evolution.
Mauroy, Benjamin, Moreau, Baptiste
core  

Equivalence of arterial and venous blood for [11C]CO2-metabolite analysis following intravenous administration of 1-[11C]acetate and 1-[11C]palmitate [PDF]

, 2013
PURPOSE: Sampling of arterial blood for metabolite correction is often required to define a true radiotracer input function in quantitative modeling of PET data. However, arterial puncture for blood sampling is often undesirable.
Brown-Proctor, Clive, Green, Mark A., Hutchins, Gary D., Mather, Kieren J., Moberly, Steven P., Ng, Yen   +5 more
core   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Total-liver-volume perfusion CT using 3-D image fusion to improve detection and characterization of liver metastases [PDF]

, 2008
The purpose of this study was to evaluate the feasibility of a totalliver- volume perfusion CT (CTP) technique for the detection and characterization of livermetastases.
Kuijk, Cornelis van, Meijer, Sybren, Meijerink, Martijn, Tol, Petrousjka van den, Waesberghe, Jan van, Weide, Lineke van der   +5 more
core   +3 more sources

DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling

FEBS Open Bio, EarlyView.
Elevated DDX3X expression led to downregulation of BMPR2, a key regulator of endothelial homeostasis and function. Our co‐immunoprecipitation assays further demonstrated a molecular interaction between DDX3X and BMPR2. Notably, DDX3X promoted lysosomal degradation of BMPR2, thereby impairing its downstream signaling and facilitating endothelial‐to ...
Yu Zhang, Jing Wang, De‐Hui Qian, Yang‐Fan Lv, Tian‐Le Cheng, Da‐Peng Wang, Jing Zhang, Ye Fan   +7 more
wiley   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Exploring the relationship of peripheral total bilirubin, red blood cell, and hemoglobin with blood pressure during childhood and adolescence

Jornal de Pediatria (Versão em Português), 2018
Objective: Total bilirubin is beneficial for protecting cardiovascular diseases in adults. The authors aimed to investigate the association of total bilirubin, red blood cell, and hemoglobin levels with the prevalence of high blood pressure in children ...
Xiao‐tian Chen, Song Yang, Ya‐ming Yang, Hai‐long Zhao, Yan‐chun Chen, Xiang‐hai Zhao, Jin‐bo Wen, Yuan‐rui Tian, Wei‐li Yan, Chong Shen   +9 more
doaj   +3 more sources

Epidural Spinal Cord Stimulation of Lumbosacral Networks Modulates Arterial Blood Pressure in Individuals With Spinal Cord Injury-Induced Cardiovascular Deficits

Frontiers in Physiology, 2018
Disruption of motor and autonomic pathways induced by spinal cord injury (SCI) often leads to persistent low arterial blood pressure and orthostatic intolerance.
Sevda C. Aslan, Sevda C. Aslan, Bonnie E. Legg Ditterline, Bonnie E. Legg Ditterline, Michael C. Park, Michael C. Park, Claudia A. Angeli, Claudia A. Angeli, Claudia A. Angeli, Enrico Rejc, Enrico Rejc, Yangsheng Chen, Yangsheng Chen, Alexander V. Ovechkin, Alexander V. Ovechkin, Andrei Krassioukov, Andrei Krassioukov, Andrei Krassioukov, Susan J. Harkema, Susan J. Harkema, Susan J. Harkema   +20 more
doaj   +1 more source