Results 81 to 90 of about 174,809 (302)

Endogenous “Time Bomb” – Mislocalized Phospholipase A2 as a Critical Mediator of Ultra‐Rapid Mortality in Sepsis and Acute Lung Injury

Advanced Science, EarlyView.
Phospholipase A2 (PLA2), a dormant enzyme, becomes lethal when activated—collapsing lungs in minutes. Our dual therapy (DOPS + varespladib) boosts survival from 0% to >90% in sepsis/ALI. A breakthrough for acute lung injury treatment. ABSTRACT This study reveals that phospholipase A2 (PLA2), normally stable and nontoxic, can be activated specifically ...
Jianyu Wang, Zhongxing Xu, Lin Wang, Xin Sui, Yuan Luo, Xiuli Zhao, Jun Yang, Yongan Wang   +7 more
wiley   +1 more source

Beyond labels: determining the true type of blood gas samples in ICU patients through supervised machine learning

BMC Medical Informatics and Decision Making
Background In the Intensive Care Unit (ICU), data stored in patient data management systems (PDMS) is commonly used in clinical practice and research. Parameters from point-of-care arterial blood gas (BG) analysis are used in the diagnosis and definition
Johan Helleberg, Anna Sundelin, Johan Mårtensson, Olav Rooyackers, Ragnar Thobaben   +4 more
doaj   +1 more source

The Predictors of Obesity Hypoventilation Syndrome in Obstructive Sleep Apnea

Balkan Medical Journal, 2017
Background: As obesity increases, the frequency of obstructive sleep apnea and obesity hypoventilation syndrome increases also. However, obesity hypoventilation syndrome frequency is not known, as capnography and arterial blood gas analysis are not ...
Aylin Pıhtılı, Züleyha Bingöl, Esen Kıyan   +2 more
doaj   +1 more source

Predictors of Intensive Care Unit admission in patients with coronavirus disease 2019 (COVID-19)

Monaldi Archives for Chest Disease, 2020
Italy is currently experiencing an epidemic of coronavirus disease 2019 (Covid-19). Aim of our study is to identify the best predictors of Intensive Care Unit (ICU) admission in patients with Covid-19.
Maria Viviana Carlino, Natja Valenti, Flavio Cesaro, Anita Costanzo, Giovanna Cristiano, Mario Guarino, Alfonso Sforza   +6 more
doaj   +1 more source

Using an Audience Response System Smartphone App to Improve Resident Education in the Pediatric Intensive Care Unit. [PDF]

, 2018
In the Pediatric Intensive Care Unit (PICU), most teaching occurs during bedside rounds, but technology now provides new opportunities to enhance education. Specifically, smartphone apps allow rapid communication between instructor and student.
Anas, Nick, Bruno, Diana, Chung, Hoyoung, Decamps, Jose, Evans, Darci, Kallay, Tom, Mink, Richard B, Vilasagar, Niveditha   +7 more
core   +2 more sources

Tailored Porous Bimetallic Nanozyme Platform for Full‐Cycle Therapeutics of Intestinal Ischemia/Reperfusion

Advanced Science, EarlyView.
ABSTRACT Intestinal ischemia/reperfusion (I/R) injury presents a biphasic pathology: an acute oxidative‐inflammatory phase leading to organ failure, and a recovery phase marked by mucosal dysfunction and bacterial translocation. The developed MPB@TA‐Cu‐Ma nanocomposite functions as a dual‐phase therapeutic platform with significant efficacy. It rapidly
Chenghao Qiu, Wenjing Xian, Mengxue Wang, Guozhi Zhao, Yanhuo Zhang, Zhiyu Zhou, Bo Sheng, Zhuo Zhen, Xie Liu, Shouwen Diao, Mengwei Tu, Chen Qiu, Huixian Wang, Jianbo Zhang, Peng Zhu, Tong Li   +15 more
wiley   +1 more source

Leukocyte sequestration in pulmonary microvessels and lung injury following systemic complement activation in rabbits [PDF]

, 1999
Inflammatory reactions are associated with sequestration of leukocytes in the lung. Complement activation leads to accumulation of leukocytes in alveolar septa and alveoli, to lung edema and hemorrhage.
Goetz, Alwin Eduard, Groh, Joachim, Kiefmann, Rainer, Kuebler, Wolfgang M., Kuhnle, Gerhard E. H., Sckell, Axel   +5 more
core   +1 more source

H2S‐Releasing Aspirin Nanoparticles Alleviate Endometriosis and Associated Anxiety

Advanced Science, EarlyView.
Albumin nanoparticles loaded with an H2S‐releasing aspirin derivative (ACS14) hitchhiking neutrophils after intraperitoneal injection and preferentially accumulate in endometriosis lesions in mice. The treatment suppresses lesion growth by regulating PI3K/Akt and reduces inflammation by inhibiting NF‐κB.
Mengni Zhou, Renbin Dou, Rong Wu, Yunyu Xu, Ying Wang, Peng Wang, Jinfu Li, Pengcheng Lu, Yu Mao, Jieying Qian, Yunjiao Zhang, Jiqian Zhang, Shasha Zhu   +12 more
wiley   +1 more source

Pulmonary shunt in critical care: a practical approach with clinical scenarios

Journal of Anesthesia, Analgesia and Critical Care
Background Pulmonary shunt refers to the passage of venous blood into the arterial blood system bypassing the alveoli-blood gas exchange. Pulmonary shunt is defined by a drop in the physiologic coupling of lung ventilation and lung perfusion.
Davide Raimondi Cominesi, Mario Forcione, Matteo Pozzi, Marco Giani, Giuseppe Foti, Emanuele Rezoagli, Francesco Cipulli   +6 more
doaj   +1 more source

Impact of Intraoperative Colloid versus Crystalloid Administration on Postoperative Outcomes in Major Gastrointestinal Surgeries: An Interventional Study [PDF]

Journal of Clinical and Diagnostic Research
Introduction: Colloids and crystalloids are frequently used for fluid resuscitation. However, their differing physiological properties may impact postoperative outcomes in distinct ways. Emerging evidence indicates that these variations could play a role
Manoj Kumar, Jay Brijesh Singh Yadav, Himanshu Prince, Matendra Singh Yadav, Prashant Kumar Mishra, Purva Kumrawat, Meera Kumari, Raghvendra Singh   +7 more
doaj   +1 more source