Structural and hemodynamic properties in murine pulmonary arterial networks under hypoxia-induced pulmonary hypertension [PDF]
arXiv, 2020 Detection and monitoring of patients with pulmonary hypertension, defined as mean blood pressure in the main pulmonary artery above 25 mmHg, requires a combination of imaging and hemodynamic measurements. This study demonstrates how to combine imaging data from microcomputed tomography (micro-CT) images with hemodynamic pressure and flow waveforms from
arxiv
Arterial stiffening provides sufficient explanation for primary hypertension [PDF]
, 2013 Hypertension is one of the most common age-related chronic diseases and by predisposing individuals for heart failure, stroke and kidney disease, it is a major source of morbidity and mortality. Its etiology remains enigmatic despite intense research efforts over many decades.
arxiv +1 more source
Application and reduction of a nonlinear hyperelastic wall model capturing ex vivo relationships between fluid pressure, area and wall thickness in normal and hypertensive murine left pulmonary arteries [PDF]
arXiv, 2022 Pulmonary hypertension is a cardiovascular disorder manifested by elevated arterial blood pressure together with vessel wall stiffening and thickening due to alterations in collagen, elastin and smooth muscle cells. Hypoxia-induced (type 3) pulmonary hypertension can be studied in animals exposed to a low oxygen environment for prolonged time periods ...
arxiv
Molecular Mechanisms of Kidney Injury and Repair in Arterial Hypertension [PDF]
, 2019 The global burden of chronic kidney disease is rising. The etiologies, heterogeneous, and arterial hypertension, are key factors contributing to the development and progression of chronic kidney disease. Arterial hypertension is induced and maintained by
Eckardt, Kai-Uwe +1 more
core +2 more sources
Pathogenic Role of mTORC1 and mTORC2 in Pulmonary Hypertension. [PDF]
, 2018 Concentric lung vascular wall thickening due to enhanced proliferation of pulmonary arterial smooth muscle cells is an important pathological cause for the elevated pulmonary vascular resistance reported in patients with pulmonary arterial hypertension ...
Ayon, Ramon J +18 more
core +1 more source
Response to pulmonary arterial hypertension drug therapies in patients with pulmonary arterial hypertension and cardiovascular risk factors. [PDF]
, 2014 The age at diagnosis of pulmonary arterial hypertension (PAH) and the prevalence of cardiovascular (CV) risk factors are increasing. We sought to determine whether the response to drug therapy was influenced by CV risk factors in PAH patients. We studied
Charalampopoulos, A +9 more
core +1 more source
Pulmonary arterial hypertension: pathogenesis and clinical management
British medical journal, 2018 Pulmonary hypertension is defined as a resting mean pulmonary artery pressure of 25 mm Hg or above. This review deals with pulmonary arterial hypertension (PAH), a type of pulmonary hypertension that primarily affects the pulmonary vasculature.
T. Thenappan +3 more
semanticscholar +1 more source
COVID‐19 and arterial hypertension: Hypothesis or evidence?
The Journal of Clinical Hypertension, 2020 Investigations reported that hypertension, diabetes, and cardiovascular diseases were the most prevalent comorbidities among the patients with coronavirus disease 2019 (COVID‐19).
M. Tadic +3 more
semanticscholar +1 more source
Transcriptional profiling of lung cell populations in idiopathic pulmonary arterial hypertension
Pulmonary Circulation, 2020 Despite recent improvements in management of idiopathic pulmonary arterial hypertension, mortality remains high. Understanding the alterations in the transcriptome–phenotype of the key lung cells involved could provide insight into the drivers of ...
D. Saygin +7 more
semanticscholar +1 more source
Cerebral autoregulation in patients with acute lacunar infarction: a reliable predictor of outcome
Annals of Clinical and Translational Neurology, EarlyView.Abstract Objective To further investigate the association between dynamic cerebral autoregulation (dCA) and the outcomes in patients with acute lacunar infarction. Methods Patients were prospectively and consecutively enrolled at The First Hospital of Jilin University between 2016 and 2023. dCA was monitored at 1–3 and 7–10 days after the stroke.
Xiang‐Kun Si +7 more
wiley +1 more source