The trajectory to diagnosis with pulmonary arterial hypertension: a qualitative study [PDF]
, 2012 Objectives To investigate the patient's experience of the trajectory to receiving a diagnosis of pulmonary arterial hypertension (PAH) and inform the provision of care for this patient group.
Armstrong, I +4 more
core +2 more sources
Advanced Science, EarlyView.Cardiovascular disease (CVD) and cancer are leading causes of death worldwide, with overlapping risk factors and pathophysiological mechanisms. This review explores shared pathways, including metabolic dysregulation, chronic inflammation, and gut microbiome alterations, highlighting dual‐benefit strategies such as lifestyle modifications and repurposed
Shihan Xiang +6 more
wiley +1 more source
Advanced Science, EarlyView.This study highlights GRK2 is a central mediator in OSS‐induced endothelial dysfunction. OSS activates GPCRs in endothelial cells, leading to GRK2 phosphorylation and the activation of AP‐1. AP‐1 induces inflammation, while also promoting NR4A1 expression and anchoring LKB1 in the nucleus, which suppresses AMPK activity. This cascade causes endothelial
Li‐Da Wu +18 more
wiley +1 more source
Association between one-hour post-load plasma glucose levels and vascular stiffness in essential hypertension [PDF]
, 2012 Objectives: Pulse wave velocity (PWV) is a surrogate end-point for cardiovascular morbidity and mortality. A plasma glucose value $155 mg/dl for the 1-hour post-load plasma glucose during an oral glucose tolerance test (OGTT) is able to identify ...
Arturi, F +8 more
core +2 more sources
Production of Prolonged Arterial Hypertension in Dogs by Chronic Stimulation of the Nervous System [PDF]
, 1951 Robert D. Taylor, Irvine H. Page
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Advanced Science, EarlyView.Epidemiological data confirm obesity elevates thoracic aortic dissection (TAD) risk. Patient analyses implicate hyperleptinemia, where leptin binding to vascular smooth muscle cell (VSMC) receptors triggers Socs3‐mediated suppression of Stat5a transcriptional activity.
Ling Chen +18 more
wiley +1 more source
Progenitor cells, bone marrow–derived fibrocytes and endothelial-to-mesenchymal transition: new players in vascular fibrosis [PDF]
, 2016 No abstract ...
Harvey, Adam +4 more
core +2 more sources
The Electrolytes of Arterial Wall in Experimental Renal Hypertension [PDF]
, 1956 Louis Tobian, LOIS WHITE
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ATF3 Deficiency Exacerbates Ageing‐Induced Atherosclerosis and Clinical Intervention Strategy
Advanced Science, EarlyView.Targeting ATF3 with terazosin to against VSMC Senescence and atherosclerosis. TZ reduces the binding affinity of YTHDF2 to Atf3 mRNA, while enhancing mRNA stability. ATF3 promotes Atg7 transcription, enhancing autophagy. ATG7 binds to ATF3 in the cytoplasm, facilitating ATF3 translocation to the nucleus and establishing positive feedback. By modulating
Hao Nie +11 more
wiley +1 more source
SENSITIVITY OF THE SMALLEST CUTANEOUS BLOOD VESSELS: QUANTITATIVE RESPONSES TO GRADED MECHANICAL STIMULATION AND TO LOCAL ISCHEMIA IN ARTERIAL HYPERTENSION, ARTERIOSCLEROSIS, AND CERTAIN ALLIED DISORDERS 1 [PDF]
, 1942 J R DiPalma, Frances I. Foster
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