Endothelial cells in the pathogenesis of pulmonary arterial hypertension
European Respiratory Journal, 2021 Pulmonary arterial hypertension (PAH) is a devastating disease that involves pulmonary vasoconstriction, small vessel obliteration, large vessel thickening and obstruction, and development of plexiform lesions.
C. Evans +4 more
semanticscholar +1 more source
ERJ Open Research, 2023 Background Converging evidence from proteogenomic analyses prioritises thrombospondin-2 (TSP2) as a potential biomarker for idiopathic or heritable pulmonary arterial hypertension (PAH).
Anna M. Dittrich +7 more
doaj +1 more source
Transient but not genetic loss of miR-451 attenuates the development of pulmonary arterial hypertension [PDF]
, 2013 <b>Rationale:</b> MicroRNAs are small non-coding RNAs involved in the regulation of gene expression and have recently been implicated in the development of pulmonary arterial hypertension (PAH).
Baker, Andrew H. +5 more
core +7 more sources
Resistant hypertension after renal infarction in a man with fibromuscular dysplasia
Blood Pressure, 2021 We report the case of 39-year-old Caucasian man presenting in emergency department with new onset of severe hypertension with hypokalaemia eight weeks after renal colic. Patient was referred to a hypertension unit for further investigation.
Nikolina Bukal +4 more
doaj +1 more source
Pulmonary arterial hypertension [PDF]
Breathe, 2005 Key pointsPAH is defined by RHC showing a pre-capillary PH.Clinical suspicion of PH should arise in the case of symptoms such as dyspnoea without overt signs of specific heart or lung disease.RHC is required to confirm the diagnosis of PAH, to assess the severity of the haemodynamic impairment and to test the vasoreactivity of the pulmonary circulation.
Xavier Jaïs +5 more
openaire +4 more sources
Cardiovascular consequences of aircraft noise exposure
Frontiers in Public Health, 2022 The results from epidemiological studies suggest that environmental noise including aircraft, railway, road traffic, wind turbine, and leisure-related noise is a growing public health concern.
Justyna Ba̧czalska +6 more
doaj +1 more source
LIT01-196, a Metabolically Stable Apelin-17 Analog, Normalizes Blood Pressure in Hypertensive DOCA-Salt Rats via a NO Synthase-dependent Mechanism [PDF]
Frontiers in Pharmacology, Frontiers, 2021, 12, 2022 Apelin is a neuro-vasoactive peptide that plays a major role in the control of cardiovascular functions and water balance, but has an in-vivo half-life in the minute range, limiting its therapeutic use. We previously developed LIT01-196, a systemically active metabolically stable apelin-17 analog, produced by chemical addition of a fluorocarbon chain ...
arxiv +1 more source
The Paradox of Pulmonary Vascular Resistance: Restoration of Pulmonary Capillary Recruitment as a \u3ci\u3eSine Qua Non\u3c/i\u3e for True Therapeutic Success in Pulmonary Arterial Hypertension [PDF]
, 2022 Exercise-induced increases in pulmonary blood flow normally increase pulmonary arterial pressure only minimally, largely due to a reserve of pulmonary capillaries that are available for recruitment to carry the flow.
Catravas, John D. +5 more
core +2 more sources
The physiological basis of pulmonary arterial hypertension
European Respiratory Journal, 2021 Pulmonary arterial hypertension (PAH) is a rare dyspnoea-fatigue syndrome caused by a progressive increase in pulmonary vascular resistance and eventual right ventricular (RV) failure.
R. Naeije, M. Richter, L. Rubin
semanticscholar +1 more source
Chronic Kidney Disease and Arterial Stiffness: A Two-Way Path
Frontiers in Medicine, 2021 The kidney-heart relationship has raised interest for the medical population since its vast and complex interaction significantly impacts health. Chronic kidney disease (CKD) generates vascular structure and function changes, with significant hemodynamic
Felipe Inserra +6 more
doaj +1 more source