Results 151 to 160 of about 85,829 (309)

Arterial stiffness and vascular aging: mechanisms, prevention, and therapy

Signal Transduction and Targeted Therapy
Cardiovascular diseases are the leading cause of morbidity and mortality worldwide. The central underlying mechanisms of cardiovascular diseases are vascular aging and associated arterial stiffness. Arterial stiffness is characterized by structural (e.g.,
Maximilian Jonathan Herzog, Patrick Müller, Katharina Lechner, Marvin Stiebler, Philipp Arndt, Matthias Kunz, Dörte Ahrens, Alexander Schmeißer, Stefanie Schreiber, Ruediger C. Braun-Dullaeus   +9 more
doaj   +1 more source

Open Intrameniscal Examination and Reduction of Depressed Tibial Plateau Fracture

Arthroscopy Techniques, EarlyView.
Abstract In the Schatzker classification, approximately 60.5% of tibial fractures can potentially involve depression fractures of the plateau, on average in types II, III, and IV, and are particularly prevalent among the elderly population. A significant challenge in managing these fractures is achieving optimal visualization of the depressed fracture ...
Sohrab Keyhani, Kamran Shirbache, Iman Menbari Oskouie, Rodrigo Pesantez, Mehdi Komijani, Fardis Vosoughi   +5 more
wiley   +1 more source

Arterial Stiffness and Obesity as Predictors of Diabetes: Longitudinal Cohort Study

JMIR Public Health and Surveillance
BackgroundPrevious studies have confirmed the separate effect of arterial stiffness and obesity on type 2 diabetes; however, the joint effect of arterial stiffness and obesity on diabetes onset remains unclear ...
Cancan Cui, Zhiyuan Wu, Jia Zheng, Jiaqi Chu, Jiajing Zhu, Yitian Qi, Zhenming Zhang, Zhijia Wang, Mengchao Zhang, Zhanhao Mo, Liangkai Cheng, Lei Ding, Xiaoping Kang, Lin Liu, Te Zhang   +14 more
doaj   +1 more source

Blood pressure effects of SGLT2 inhibitors and GLP‐1 receptor agonists: Mechanisms, trial evidence and Real‐world data

British Journal of Clinical Pharmacology, EarlyView.
SGLT2 inhibitors and GLP‐1 receptor agonists modestly lower blood pressure across diverse patient populations, including those without diabetes. These effects appear largely independent of glycaemic control and offer additive value in high‐risk patients with overlapping comorbidities.
Andrej Belančić, Yusuf Ziya Sener, Marijana Vučković, Joseph Edgar Blais, Almir Fajkić, Emina Sher, Mislav Radić, Josipa Radić   +7 more
wiley   +1 more source

The predictive value of arterial stiffness on major adverse cardiovascular events in individuals with mildly impaired renal function

, 2016
Jie Han,* Xiaona Wang,* Ping Ye, Ruihua Cao, Xu Yang, Wenkai Xiao, Yun Zhang, Yongyi Bai, Hongmei Wu Department of Geriatric Cardiology, Chinese PLA General Hospital, Beijing, People’s Republic of China *These authors contributed equally to  ...
Yang X, Ye P, Zhang Y, Xiao W, Han J, Wang X, Bai Y, Cao R, Wu H   +8 more
core  

Role of elastin and elastin-derived peptides in arterial stiffness: from synthesis to potential therapeutic interventions

299313The vascular wall is a composite environment made of a myriad of different cell types and a complex extracellular matrix (ECM). The latter has a direct impact on vessel function and pathophysiological remodeling of ECM is associated with ...
Jaisson, Stéphane, Laffargue, Muriel, Romier-Crouzet, Béatrice, Duca, Laurent, Schmelzer, Christian E.H., Sartelet, Hervé, Wahart, Amandine, Bennasroune, Amar H., Martiny, Laurent, Blaise, Sébastien A., Gillery, Philippe, Maurice, Pascal   +11 more
core   +1 more source

Possible therapeutic repositioning of valproic acid: From epileptic seizures to acute kidney injury

British Journal of Clinical Pharmacology, EarlyView.
Valproic acid, an anticonvulsant, may be repositioned to prevent acute kidney injury due to ischemia followed by reperfusion. It preserves renal functions, electrolyte homeostasis and active sodium transport in kidney tubules, and blocks the onset of hypertension.
Danilo Alves‐Bezerra, Luiza B. Negreiros, Amaury Pereira‐Acácio, Isadora G. Almeida, João P. M. Veloso‐Santos, Jarlene A. Lopes, Glória Costa‐Sarmento, Humberto Muzi‐Filho, Adalberto Vieyra   +8 more
wiley   +1 more source

Advancing design strategies in smart stimulus‐responsive liposomes for drug release and nanomedicine

BMEMat, EarlyView.
Schematic illustration of stimulus‐responsive liposomes designed for controlled drug release and nanomedicine. The innermost circle represents different liposomal structures, including unilamellar, multilamellar, and multivesicular liposomes. The middle layer illustrates the responsive phospholipid components.
Yuchen Guo, Nan Li, Daiwei Zhang, Jingya Gu, Zhihuan Liao, Zihao Teng, Xiangfu Du, Peter S. Timashev, Shipeng Chen, Shuaidong Huo   +9 more
wiley   +1 more source

Marine silicon for biomedical sustainability

BMEMat, EarlyView.
Schematic illustrating marine silicon for biomedical engineering. Abstract Despite momentous divergence from oceanic origin, human beings and marine organisms exhibit elemental homology through silicon utilization. Notably, silicon serves as a critical constituent in multiple biomedical processes.
Yahui Han, Zhibo Yang, Wei Xia, Chengtie Wu   +3 more
wiley   +1 more source

Radial capacity and hemodynamics evaluation in vitro and implantable feasibility validation in vivo of thinner bioresorbable polymer vascular stents

BMEMat, EarlyView.
A series of in vitro experiments, numerical simulations and in vivo experiments were conducted to jointly evaluate the effects of different thicknesses of bioabsorbable polymer vascular stents on their radial capacity, hemodynamics and in vivo outcomes.
Chong Chen, Tao Li, Zhongyou Li, Jingyuan Zhou, Zhuo Zhang, Yan Xiong, Rifang Luo, Yu Chen, Yunbing Wang, Ping Fu   +9 more
wiley   +1 more source