Results 331 to 340 of about 1,316,710 (378)

Deep phenotyping of heart failure with preserved ejection fraction through multi‐omics integration

European Journal of Heart Failure, EarlyView.
Deep phenotyping of of heart failure with preserved ejection fraction (HFpEF) through multi‐omics integration. AI, artificial intelligence. Aims Heart failure with preserved ejection fraction (HFpEF) has become the predominant form of heart failure and a leading cause of global cardiovascular morbidity and mortality.
Jakob Versnjak, Titus Kuehne, Pauline Fahjen, Nina Jovanovic, Ulrike Löber, Gabriele G. Schiattarella, Nicola Wilck, Holger Gerhardt, Dominik N. Müller, Frank Edelmann, Philipp Mertins, Roland Eils, Michael Gotthardt, Sofia K. Forslund, Benjamin Wild, Marcus Kelm   +15 more
wiley   +1 more source

The relationship between different severity of COVID-19 pneumonia and arterial stiffness based on artificial intelligence analysis. [PDF]

Front Med (Lausanne)
Wu L, Jin L, Li X, Zhang M, Chen J, Tang X, Du L, Wang X, Li Z, Luo X.   +9 more
europepmc   +1 more source

Left ventricular transthyretin amyloid load and apical sparing in patients with newly confirmed transthyretin amyloid cardiomyopathy

European Journal of Heart Failure, EarlyView.
In a large cohort of patients with newly diagnosed transthyretin amyloid cardiomyopathy (ATTR‐CM), echocardiographic apical sparing was associated with increased left ventricular amyloid load and atrial remodelling. Quantitative biopsy analysis revealed that Perugini scores often failed to accurately reflect myocardial amyloid burden.
Thomas Krammer, Maria J. Baier, Vanessa Lutz, Anna‐Christina Hübner, Tilman Zschiedrich, David Lukas, Christian Le Phu, Matthias Wolf, Claire Maassen, Michael Wester, Stefan Neef, Christian Schach, Can‐Martin Sag, Katja Evert, Michael Paulus, Christine Meindl, Maria Tafelmeier, Kurt Debl, Lars S. Maier, Stefan Wagner, Christoph Röcken, Julian Mustroph   +21 more
wiley   +1 more source

Blood Pressure Mediates the Association Between Visceral-to-Subcutaneous Fat Ratio and Arterial Stiffness in Patients With Type 2 Diabetes. [PDF]

J Diabetes Res
Tang D, Gu X, Xuan Y, Zhu F, Shen Y, Lu L.   +5 more
europepmc   +1 more source

Adverse Outcome Pathways Applied to Space Radiation Research

Environmental and Molecular Mutagenesis, EarlyView.
ABSTRACT Long‐duration spaceflight exposes astronauts to various stressors that can alter human physiology, potentially causing immediate and long‐term health effects. These stressors can damage biomolecules, cells, tissues, and organs, leading to adverse outcomes.
Vinita Chauhan, Veronica S. Grybas, Devyn Hoopfer, Casey Higginson, Elizabeth A. Ainsbury, Omid Azimzadeh, Afshin Beheshti, Steve Blattnig, Marjan Boerma, Sylvain V. Costes, Stephen Doty, Christelle Adam‐Guillermin, Nobuyuki Hamada, Patricia Hinton, Janice L. Huff, Robert Reynolds, Ruth C. Wilkins, Scott Wood, Carole L. Yauk   +18 more
wiley   +1 more source

Carotid intima‐media thickness may be an early biomarker for cardiovascular risk in patients treated with ketogenic dietary therapy

Epilepsia Open, EarlyView.
Abstract Objective To assess early signs of atherosclerosis following long‐term treatment with the ketogenic diet therapy due to concerns regarding the impact of this low‐carbohydrate, high‐fat diet on cardiovascular health. Method In this cohort study, 28 patients aged 6 to 49 years who had been treated with ketogenic diet therapy for more than five ...
Kathrine C. Haavardsholm, Mahtab Zamani, Mona Skjelland, Anette Ramm‐Pettersen, Karolina Skagen   +4 more
wiley   +1 more source

Integrative Evidence From Metabolome‐Wide Mendelian Randomization and Animal Models Implicates Tyrosine in Cardiac Hypercontractility and Arrhythmia Risk

Food Frontiers, EarlyView.
Plasma metabolome‐wide Mendelian randomization analysis established a causal link between tyrosine and arrhythmia. GWAS meta‐analysis identified tyrosine‐associated loci linked to cardiovascular risk factors. Animal studies confirmed that oral tyrosine intake modulates heart rhythm via adrenergic signaling activation.
Zhikang Cao, Huiying Liu, Peng Chen, Liyue Chen, Zhixin Chen, Jiaqiang Lin, Zixuan Fu, Zhipeng Li   +7 more
wiley   +1 more source

Alteration in Carotid Arterial Stiffness During Passive Leg Raising May Reflect Vascular Endothelial Function. [PDF]

Circ Rep
Okada K, Nakabachi M, Hayashi Y.
europepmc   +1 more source

Multiparametric Ultrasound for Preoperative Assessment of Parotid Tumors: A Novel Diagnostic Pathway

Head &Neck, EarlyView.
ABSTRACT Background Accurate preoperative differentiation of parotid gland tumors (PGTs) is essential for facial nerve preservation. This study evaluates a novel, real‐time multiparametric ultrasound (mpUS) approach combining B‐mode, shear wave elastography (SWE), and contrast‐enhanced ultrasound (CEUS), based on qualitative image interpretation ...
Katharina Margherita Wakonig, Markus Herbert Lerchbaumer, Philipp Arens, Heidi Olze, Steffen Dommerich, Thomas Fischer   +5 more
wiley   +1 more source

Interactive effects of arterial stiffness and Alzheimer's disease risk on cognitive decline in older adults without dementia. [PDF]

Alzheimers Dement
Edwards L, Smirnov DS, Thomas KR, Longardner K, Delano-Wood L, Bondi MW, Salmon DP, Galasko D, Bangen KJ.   +8 more
europepmc   +1 more source