Results 201 to 210 of about 6,960 (260)

Proteomic Profiling Captures Residual Cardiovascular Risk Beyond the PREVENT Model in Individuals With Cardiovascular–Kidney–Metabolic Syndrome Stages 2–3

open access: yesDiabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Background Cardiovascular–kidney–metabolic (CKM) syndrome reflects complex pathobiological interactions among metabolic disorders, kidney injury, and cardiovascular disease (CVD). Stages 2 and 3 represent critical phases of disease progression characterised by high pathological heterogeneity.
Xuefei Han   +4 more
wiley   +1 more source

Acute GIP and GLP‐1 Administration Exerts Differential Metabolic Effects in Totally Pancreatectomised Individuals

open access: yesDiabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims While being recognised for stimulating pancreatic insulin secretion, GIP and GLP‐1 exert various extrapancreatic effects relevant in the context of incretin‐based therapies. Here, we evaluated the extrapancreatic effects of GIP and GLP‐1, separately and combined, on postprandial physiology in totally pancreatectomised individuals ...
Liva S. L. Krogh   +8 more
wiley   +1 more source

Equine eyelid reconstruction by semi‐circular skin flap blepharoplasty

open access: yesEquine Veterinary Education, EarlyView.
Summary Reconstructive surgeries of the equine eyelid carry significant challenges for the equine surgeon, due to the poorly mobile and tightly adhered facial skin in this species. Preservation of lid function is an essential surgical consideration in order to maintain protection of the globe and cornea and to provide ocular comfort to the case ...
V. J. Jordan, D. Leong, C. Hartley
wiley   +1 more source

Proteolysis at the extracellular matrix interface: Molecular architects and regulators in health and disease

open access: yesThe FEBS Journal, EarlyView.
The extracellular matrix (ECM) is a dynamic scaffold that orchestrates tissue architecture and cellular communication. A critical but underexplored interplay between proteases and cluster of differentiation molecules (CD) governs ECM turnover and directs cell fate.
David Jurnečka   +3 more
wiley   +1 more source

ADAM17 and its proteolytic targets in disease pathogenesis

open access: yesThe FEBS Journal, EarlyView.
ADAM17 as a multifunctional sheddase with contrasting roles across inflammatory, metabolic, cardiovascular, and neoplastic diseases. Through regulated activation by iRhom, iTAP/FRMD8, and tetraspanins, ADAM17 cleaves diverse membrane ligands and receptors, thereby promoting inflammation, fibrosis, obesity, insulin resistance, and tumor progression ...
Abdulbasit Amin, Marina Badenes
wiley   +1 more source

Associations Between Multimorbidity, Polypharmacy and Oral Conditions in Older Adults: A Systematic Review and Meta‐Analysis

open access: yesGerodontology, EarlyView.
ABSTRACT Objective This systematic review and meta‐analysis evaluated the relationship between multimorbidity and polypharmacy on the oral health in older adults (aged 75 years or older). The PECO focus question set for this study was, ‘What is the occurrence, association and impact of multimorbidity and polypharmacy on the oral conditions and its ...
Kittipit Srisanoi   +5 more
wiley   +1 more source

Effects of Regular Dual‐Light Antibacterial Photodynamic Therapy on Oral Health in Assisted Living Residents—A Randomized Controlled Trial

open access: yesGerodontology, EarlyView.
ABSTRACT Objective The objective of this study is to investigate the effect of dual‐light antimicrobial photodynamic therapy (aPDT) on oral health among older people living in assisted living facilities (ALF), comparing it to conventional oral self‐care guidance.
Wilma Romppanen   +7 more
wiley   +1 more source

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