Results 301 to 310 of about 1,239,872 (342)

Tie2‐Dependent Mechanisms Influence Leptomeningeal Collateral Dynamics and Reperfusion Following Stroke

open access: yesAdvanced Science, EarlyView.
This work demonstrates that endothelial EphA4 limits Tie2 activation and curbs leptomeningeal collateral expansion after ischemic stroke. Pharmacological activation of Tie2 by an Ang‐1 mimetic or genetic loss of EphA4 stimulates collateral vessel growth, improves cerebral perfusion, and enhances neurological recovery.
Alexandra M. Kaloss   +9 more
wiley   +1 more source

ADAR1 as a Placental Innate Immune Rheostat Sustaining the Homeostatic Balance of Intrinsic Interferon Response at the Maternal‐Fetal Interface

open access: yesAdvanced Science, EarlyView.
This study reveals that ADAR1, an RNA‐editing enzyme, fine‐tunes immune responses in the placenta by preventing the accumulation of immunogenic double‐stranded RNAs (dsRNAs) from interferon‐stimulated genes. The loss of ADAR1 in the placenta leads to excessive interferon signaling restricted to the junctional zone, disrupting placental development and ...
Xiaogang Chen   +7 more
wiley   +1 more source

Pathogenicity of Mediator Complex Subunit 27 (MED27) in a Neurodevelopmental Disorder with Cerebellar Atrophy

open access: yesAdvanced Science, EarlyView.
MED27 is one of the 26 subunits in the human Mediator complex (MED). Neurodevelopmental disorder‐causing MED27 genetic variants induce instability of MED, leading to disrupted DNA occupancy, altered chromatin interaction, and subsequent transcriptional dysregulation of critical downstream genes, including master regulatory transcription factors ...
Nuermila Yiliyaer   +18 more
wiley   +1 more source

Double Versus Single Hepatic Artery Anastomosis in Pediatric Left Liver Grafts: A Reassessment of Outcomes. [PDF]

open access: yesPediatr Transplant
Costa CM   +18 more
europepmc   +1 more source

Clinical profile and long-term outcomes of pediatric-onset Takayasu's arteritis: data from a mexican national referral center. [PDF]

open access: yesPediatr Rheumatol Online J
Pagoaga-Vásquez DP   +8 more
europepmc   +1 more source

Surgical management of a ruptured cirsoid aneurysm: illustrative case. [PDF]

open access: yesJ Neurosurg Case Lessons
De Paulis D   +7 more
europepmc   +1 more source

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