Results 311 to 320 of about 2,251,525 (387)

Targeting miRNA‐1a and miRNA‐15b: A Novel Combinatorial Strategy to Drive Adult Cardiac Regeneration

open access: yesAdvanced Science, EarlyView.
The article explores a novel therapeutic strategy for cardiac regeneration by targeting miRNA‐1a and miRNA‐15b. Combinatorial inhibition of miR‐1a and miR‐15b enhances cardiomyocyte proliferation, improves heart function, and reduces fibrosis in myocardial infarction models.
Ting Yuan   +16 more
wiley   +1 more source

Uncover Hidden Physical Information of Soft Matter by Observing Large Deformation

open access: yesAdvanced Science, EarlyView.
Detecting internal abnormalities in soft matter remains challenging due to its heterogeneous nature. This study introduces a method that infers hidden physical properties by matching observed deformation with simulation through parallel Bayesian optimization.
Huanyu Yang   +9 more
wiley   +1 more source

CXCL13 Damages Blood Spinal Cord Barrier by Promoting RNF6/Sqstm1‐Ubiquitination Induced Autophagy in Experimental Allergic Encephalomyelitis

open access: yesAdvanced Science, EarlyView.
In multiple sclerosis, the disruption of the blood‐spinal cord barrier (BSCB) induced by CXCL13 facilitates the infiltration of inflammatory cells into the central nervous system, resulting in demyelination and neuronal injury. Mechanistically, the deleterious impact of CXCL13 on the BSCB is associated with a reduction in tight junction protein ...
Jingjing Han   +10 more
wiley   +1 more source

Engineering the Immune Response to Biomaterials

open access: yesAdvanced Science, EarlyView.
This paper reviews immune responses to biomaterials, stages of evolution in relation to managing these responses ranging from preventing to modulating them. It also discusses state‐of‐the‐art strategies to modulate these responses and modes of their delivery.
Abolfazl Salehi Moghaddam   +12 more
wiley   +1 more source

Development of Carbon‐11 Labeled Pyrimidine Derivatives as Novel Positron Emission Tomography (PET) Agents Enabling Brain Sigma‐1 Receptor Imaging

open access: yesAdvanced Science, EarlyView.
Novel carbon‐11 labeled pyrimidine derivatives are developed as PET imaging probes for visualizing sigma‐1 receptors in the brain. [11C]CNY‐01 demonstrates superior brain uptake and binding specificity in both rodents and non‐human primates. The study reveals decreased sigma‐1 receptor expression in Alzheimer's disease, offering a promising tool for ...
Ping Bai   +12 more
wiley   +1 more source

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