Results 321 to 330 of about 3,603,562 (358)

Targeted Delivery of CNS‐Specific Hesperidin as a Leptin Sensitizer for Treating Obesity‐Associated Sleep‐Disordered Breathing

open access: yesAdvanced Science, EarlyView.
Hesperidin nanoparticles (HE NPs) effectively combat obesity and sleep‐disordered breathing in mice by enhancing leptin sensitivity. Through suppression of hypothalamic endoplasmic reticulum stress and restoration of leptin signaling, HE NPs promote weight loss and improve breathing during sleep.
Yixuan Wang   +11 more
wiley   +1 more source

FMO2 Promotes Angiogenesis via Regulation of N‐Acetylornithine

open access: yesAdvanced Science, EarlyView.
This study identifies flavin‐containing monooxygenase 2 (FMO2) as a novel proangiogenic regulator in endothelial cells. Targeted FMO2 ablation impairs vessel sprouting, whereas its compensation potently enhances angiogenesis. Metabolomics and single‐cell sequencing reveal that FMO2 drives vascular growth via the N‐acetylornithine/ATF3/NOTCH1 axis ...
Jingyi Wang   +15 more
wiley   +1 more source

S···O Conformation Locks Synergistic Alkoxy Chain Engineering of NIR‐II Phototheranostic Molecules for Precision Hepatocellular Carcinoma Theranostics

open access: yesAdvanced Science, EarlyView.
This study introduces a synergistic S‐O conformation locking and alkoxy chain engineering strategy to enhance S‐D‐A‐D‐S molecular planarity. The engineered IR‐BTOG achieves concurrent NIR‐IIa absorption and NIR‐IIb emission, demonstrating exceptional photothermal efficiency and fluorescence quantum yield.
Gui‐long Wu   +10 more
wiley   +1 more source

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