Results 241 to 250 of about 1,220,899 (350)

Pharmacomicrobiomics

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Oral medications encounter gut commensal microbes that participate directly and indirectly in drug effects through metabolism, interactions with drug metabolites, or production of substrates that compete with drugs for drug‐metabolizing enzymes, consequently influencing drug pharmacokinetics.
Naomi Gronich   +11 more
wiley   +1 more source

Evolving Real‐World Data and Evidence Use for New Drugs and Regenerative Medical Products Approvals in Japan—An Analysis of the 6‐Year Trend

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Several regulatory initiatives have been made to clarify the acceptability and requirements of real‐world data and real‐world evidence (RWD/E) for the benefit/risk assessment of new medical products in Japan. The objectives of this review were to characterize the use of RWD/E in regulatory applications of new medical products and to describe the ...
Suguru Okami   +2 more
wiley   +1 more source

Methotrexate-Induced Pneumonitis in a Patient with Chronic Chikungunya Arthritis. [PDF]

open access: yesRev Soc Bras Med Trop
Oliveira JL   +3 more
europepmc   +1 more source

Infectious arthritis I

open access: yes, 2015
Emilio Martín-Mola, Alejandro Balsa
openaire   +2 more sources

A practical approach to panel design, validation, and interpretation for the evaluation of T‐cell neoplasms by flow cytometry

open access: yesCytometry Part B: Clinical Cytometry, EarlyView.
Abstract The diagnosis of T‐cell neoplasms remains one of the most challenging areas in hematopathology due to the immunophenotypic heterogeneity and subtle aberrancies often present in these entities. This “Best Practice” manuscript provides a practical framework for laboratories to design, validate, and interpret immunophenotyping studies of immature
Jean Oak   +10 more
wiley   +1 more source

Editorial: Improve immunity against infection and tumor by regulating gut microbiota. [PDF]

open access: yesFront Cell Infect Microbiol
Cai Y, Mokhtar NM, Ayerdi SGS, Kang Y.
europepmc   +1 more source

RORγt‐APCs: The New Masters of Oral Tolerance

open access: yesBarrier Immunity, EarlyView.
ABSTRACT Oral tolerance is defined by the hypo‐responsiveness of our body to fed antigens, and its failure can lead to immune‐mediated diseases, such as allergy, chronic inflammation and autoimmune diseases. Decades of research have demonstrated that antigen‐presenting cells (APCs) promote oral tolerance by inducing regulatory T cells (Tregs) and/or ...
Thierry Gauthier, WanJun Chen
wiley   +1 more source

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