Results 121 to 130 of about 784,373 (290)

Methotrexate in juvenile idiopathic arthritis: advice and recommendations from the MARAJIA expert consensus meeting

Pediatric Rheumatology Online Journal, 2018
BackgroundConventional pharmacological therapies for the treatment of juvenile idiopathic arthritis (JIA) consist of non-biological, disease-modifying antirheumatic drugs, among which methotrexate (MTX) is the most commonly prescribed.
G. Ferrara, Greta Mastrangelo, P. Barone, F. La Torre, S. Martino, G. Pappagallo, A. Ravelli, A. Taddio, F. Zulian, R. Cimaz   +9 more
semanticscholar   +1 more source

Modulators of Diacylglycerol Kinase Activity: A Review of Advances and Challenges

Medicinal Research Reviews, EarlyView.
ABSTRACT Catalyzing the conversion of diacylglycerol (DAG) in phosphatidic acid (PA), diacylglycerol kinases (DGKs) play a pivotal role in all the physiological processes modulated by these two bioactive lipids, such as lipid metabolism and immune regulation.
Luisa Racca, Gianluca Baldanzi, Alberto Massarotti   +2 more
wiley   +1 more source

Serum S100A8/A9 and S100A12 Levels in Children With Polyarticular Forms of Juvenile Idiopathic Arthritis: Relationship to Maintenance of Clinically Inactive Disease During Anti–Tumor Necrosis Factor Therapy and Occurrence of Disease Flare After Discontinuation of Therapy

Arthritis & Rheumatology, 2019
To determine the relationship between serum levels of S100A8/A9 and S100A12 and the maintenance of clinically inactive disease during anti–tumor necrosis factor (anti‐TNF) therapy and the occurrence of disease flare following withdrawal of anti‐TNF ...
C. Hinze, D. Foell, Anne L. Johnson, S. Spalding, B. Gottlieb, Paula W. Morris, Y. Kimura, K. Onel, Suzanne C. Li, A. Grom, Janalee Taylor, H. Brunner, J. Huggins, J. Nocton, K. Haines, B. Edelheit, M. Shishov, L. Jung, C. Williams, M. Tesher, D. Costanzo, L. Zemel, J. Dare, M. Passo, K. Ede, J. Olson, E. Cassidy, T. Griffin, L. Wagner-Weiner, J. Weiss, L. Vogler, K. Rouster-Stevens, T. Beukelman, R. Cron, D. Kietz, K. Schikler, J. Mehta, T. Ting, J. Verbsky, A. Eberhard, Bin Huang, E. Giannini, D. Lovell   +42 more
semanticscholar   +1 more source

Comparative evaluation of supervised and unsupervised deep learning strategies for denoising hyperpolarized 129Xe lung MRI

Magnetic Resonance in Medicine, EarlyView.
Abstract Purpose Reduced signal‐to‐noise ratio (SNR) in hyperpolarized 129Xe MR images can affect accurate quantification for research and diagnostic evaluations. Thus, this study explores the application of supervised deep learning (DL) denoising, traditional (Trad) and Noise2Noise (N2N) and unsupervised Noise2void (N2V) approaches for 129Xe MR ...
Abdullah S. Bdaiwi, Matthew M. Willmering, Riaz Hussain, Erik Hysinger, Jason C. Woods, Laura L. Walkup, Zackary I. Cleveland   +6 more
wiley   +1 more source

Features of Cellular and Humoral Immunity Functioning in Patients with Juvenile Rheumatoid Arthritis

Bolʹ, Sustavy, Pozvonočnik, 2015
The objective was to examine the state of cellular and humoral immunity in children with juvenile rheumatoid arthritis. The study involved 48 patients with juvenile rheumatoid arthritis, 24 patients with reactive arthritis and 22 apparently healthy ...
H.A. Pavlyshyn, T.A. Kovalchuk, O.R. Boiarchuk, T.V. Hariian   +3 more
doaj   +1 more source

Juvenile rheumatoid arthritis

Journal of Osteopathic Medicine, 1996
Abstract Musculoskeletal problems account for the majority of initial complaints attended to by primary care physicians. It is likely that a child who eventually has juvenile rheumatoid arthritis diagnosed will initially be evaluated by a family physician or a pediatrician. Primary care physicians will play an increasingly important role
Raymond M. Pertusi, Bernard R. Rubin, Deborah L. Blackwell   +2 more
openaire   +3 more sources

Innately Adaptive or Truly Autoimmune: Is There Something Unique About Systemic Juvenile Idiopathic Arthritis?

Arthritis & Rheumatology, 2019
Systemic juvenile idiopathic arthritis (JIA) is a form of arthritis in childhood that is initially dominated by innate immunity–driven systemic inflammation and is thus considered a polygenic autoinflammatory disease.
C. Kessel, C. Hedrich, D. Foell
semanticscholar   +1 more source

Efficacy of adalimumab in young children with juvenile idiopathic arthritis and chronic uveitis: A case series [PDF]

, 2014
Background: Juvenile idiopathic arthritis is a relatively common chronic disease of childhood, and is associated with persistent morbidity and extra-articular complications, one of the most common being uveitis.
Cattalini, Marco, Iannone, Florenzo, La Torre, Francesco, Meini, Antonella, Moramarco, Fulvio, Teruzzi, Barbara   +5 more
core   +2 more sources

Six Drivers of Aging Identified Among Genes Differentially Expressed With Age

Aging Cell, EarlyView.
A meta‐analysis of 25 transcriptomic datasets from mammalian tissues revealed 45 genes consistently upregulated or downregulated with age. Orthologs of these genes were functionally evaluated using Caenorhabditis elegans lifespan screens to reveal those with causal roles in the aging process, thus identifying six evolutionarily conserved drivers of ...
Ariella Coler‐Reilly, Zachary Pincus, Erica L. Scheller, Roberto Civitelli   +3 more
wiley   +1 more source

Association of Pharmacologic Markers of Anti-Tumor Necrosis Factor-α Activity and Etanercept Effectiveness in Juvenile Idiopathic Arthritis. [PDF]

Pharmacol Res Perspect
Relationship of pharmacologic markers of ETN response with ETN effectiveness in patients with JIA. Plasma (A) ETN concentrations, (B) anti‐TNFα activity, and (C) TNFα concentrations in patients with JIA based on the presence of active or inactive disease at the time of sampling. Data is plotted as box and whisker plots and assessed by unpaired analysis
Arain MI, Polireddy K, Fricovsky ES, Becker ML, Kazi M, Funk RS.   +5 more
europepmc   +2 more sources