Results 171 to 180 of about 784,373 (290)

«METHOTREXATE ERA» IN CHILDREN RHEUMATOLOGY

open access: yesВопросы современной педиатрии, 2006
This article sites modern principles and theoretical substantiation of pharmacotherapy by methotrexate in patients with juvenile arthritis. Particular emphasis has been placed on parenter al methods of drug introduction, as the possibility of therapy ...
S.R. Rodionovskaya, I.P. Nikishina
doaj  

Innate Lymphoid Cell Phenotypic and Functional Alterations in Patients With Systemic Juvenile Idiopathic Arthritis

open access: yesArthritis &Rheumatology, Volume 77, Issue 10, Page 1442-1450, October 2025.
Objective Systemic juvenile idiopathic arthritis (sJIA) is a chronic childhood disease classically attributed to innate immune cell dysregulation. This study aimed to elucidate the role of innate lymphoid cells (ILCs), including natural killer (NK) cells and helper‐ILCs (hILCs), in sJIA during clinically inactive disease (CID) through phenotypic and ...
Linda Quatrini   +19 more
wiley   +1 more source

Population pharmacokinetic modelling of prednisolone in systemic lupus erythematosus patients: Analysis of exposure and disease activity

open access: yesBritish Journal of Clinical Pharmacology, Volume 91, Issue 10, Page 2854-2864, October 2025.
Abstract Aims Prednisone is a widely used glucocorticoid in the treatment of lupus, although its dosing is often determined empirically. Prednisolone, the active metabolite of prednisone, is found in its free form in the serum. The goal of this study was to develop a population pharmacokinetic model in patients with systemic lupus erythematosus (SLE ...
Naïm Bouazza   +26 more
wiley   +1 more source

PRACTICE OF INFLIXIMAB TREATMENT OF A PATIENT WITH SEVERE POLIARTICULAR JUVENILE RHEUMATOID ARTHRITIS

open access: yesВопросы современной педиатрии, 2011
This article contains observation of severe poliarticular variant of juvenile rheumatoid arthritis, resistant to glucocorticoid treatment and classic immunosuppressive therapy.
T.V. Sleptsova   +5 more
doaj  

Immune‐Mediated Necrotizing Myopathy Diagnosis and Flare in an Adolescent After COVID‐19 Vaccine

open access: yesClinical Case Reports, Volume 13, Issue 10, October 2025.
Muscle biopsy is histopathologically consistent with a diagnosis of immune‐mediated necrotizing myopathy. ABSTRACT We discuss a teenager who developed a rare pediatric autoimmune muscle disease after completing the primary COVID‐19 vaccine series, which flared shortly after COVID‐19 booster vaccination.
Patricia Hoffman   +3 more
wiley   +1 more source

Tocilizumab Dosing for Management of T Cell‐Engaging Bispecific Antibody‐Related CRS in Patients With R/R B‐Cell NHL

open access: yesClinical Pharmacology &Therapeutics, Volume 118, Issue 4, Page 917-927, October 2025.
Tocilizumab dosing for management of T cell‐engaging bispecific antibody‐related CRS in patients with R/R B‐cell NHL. The recent surge in T‐cell‐engaging and chimeric antigen receptor (CAR) T‐cell therapies is changing the landscape of cancer therapy.
Candice Jamois   +13 more
wiley   +1 more source

Autoimmune Type 1 Diabetes in the Era of Disease‐Modifying Immune Therapy

open access: yesDiabetes/Metabolism Research and Reviews, Volume 41, Issue 7, October 2025.
While disease‐modifying therapies (DMTs) have been used to treat autoimmune diseases for decades, until recently, DMTs had not been used to treat autoimmune type 1 diabetes (T1D). The approval of the first DMT for use in individuals with preclinical T1D, teplizumab, has ushered in a new era in which healthcare providers can slow the T1D disease course.
Aaron W. Michels   +3 more
wiley   +1 more source

Epilepsy and systemic autoimmune diseases: A bidirectional two‐sample Mendelian randomization study

open access: yesEpilepsia Open, Volume 10, Issue 5, Page 1415-1425, October 2025.
Abstract Objective Epidemiological data indicates that individuals with epilepsy exhibit an elevated susceptibility to autoimmune disorders, and conversely, those with systemic autoimmune diseases (SAD) demonstrate a heightened predisposition to epilepsy.
Ruoshi Tian   +4 more
wiley   +1 more source

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