Results 91 to 100 of about 49,298 (201)
International Journal of Laboratory Hematology, Volume 48, Issue 2, Page 392-401, April 2026.ABSTRACT Introduction D‐dimers are produced by lysis of cross‐linked fibrin. In children, D‐dimer testing is used to evaluate disseminated intravascular coagulation (DIC) and some inflammatory states, but its use is not validated for screening or ruling out suspected venous thromboembolic events (VTE).
Rabab Al Dawood +4 more
wiley +1 more source
Immunology, Volume 177, Issue 4, Page 736-748, April 2026.A constant rate of DNA damage that is not perfectly repaired will cause a constant rate of DNA mutations. The chance of mutation will increase if DNA is prone to damage, such as occurs in somatic hypermutation (SHM) hotspots and GC‐rich DNA. Thus, if one mutation‐prone DNA site drives disease, the age of onset of disease and degree of penetrance should
Piet C. de Groen
wiley +1 more source
Orthodontics &Craniofacial Research, Volume 29, Issue 2, Page 300-308, April 2026.ABSTRACT Objective This study aimed to provide age‐related osseous measures of the temporomandibular joints (TMJs) and mandibular ramus in asymptomatic children and adolescents and to develop percentile reference data for ramus height. Material and Methods A retrospective cross‐sectional study was conducted on 133 asymptomatic participants (67 males ...
Juliet Zuying Shen +4 more
wiley +1 more source
The FASEB Journal, Volume 40, Issue 6, 31 March 2026.Here, Systemic Sonic Hedgehog (Shh) emerges as a sex‐specific metabolic signal and potential biomarker. Across two large cohorts, Shh rose selectively in females with type 2 diabetes, with a sharp pre‐diagnostic increase in about one‐quarter of cases, indicating value for early risk stratification.
Johannes Alfredsson +11 more
wiley +1 more source
ACR Open Rheumatology, Volume 8, Issue 3, March 2026.Objective To characterize clinical and transcriptomic differences in juvenile scleromyositis overlap (jOverlap) compared to juvenile systemic sclerosis (jSSc) and juvenile dermatomyositis (JDM), focusing on autoantibody profiles, organ involvement, treatment, and peripheral blood gene expression.
Amanda D. Robinson +6 more
wiley +1 more source
ACR Open Rheumatology, Volume 8, Issue 3, March 2026.Objective Juvenile‐onset systemic sclerosis (jSSc) is a rare, heterogeneous pediatric autoimmune disease. Existing severity tools are often adapted from adult systemic sclerosis and lack pediatric‐specific validation. The Juvenile Systemic Sclerosis Severity Score (J4S) was developed to address this gap by capturing multiorgan disease burden.
Samantha A. Branton, Kathryn S. Torok
wiley +1 more source
Elevated Peripheral CD161+ Treg Cells and Their Clinical Significance in Behçet Syndrome
ACR Open Rheumatology, Volume 8, Issue 3, March 2026.Objective Behçet syndrome (BS) is a systemic autoimmune vasculitis characterized by immune dysregulation involving multiple immune cell subsets. CD161+ Treg cells exhibit proinflammatory properties and impair immune regulation during inflammation. This study aimed to investigate the alterations in CD161+ Treg cells in BS and their clinical relevance ...
Jiachen Li +9 more
wiley +1 more source
Engineering Immune Cell to Counteract Aging and Aging‐Associated Diseases
Advanced Science, Volume 13, Issue 14, 9 March 2026.This review highlights a paradigm shift in which advanced immune cell therapies, initially developed for cancer, are now being harnessed to combat aging. By engineering immune cells to selectively clear senescent cells and remodel pro‐inflammatory tissue microenvironments, these strategies offer a novel and powerful approach to delay age‐related ...
Jianhua Guo +5 more
wiley +1 more source
American Journal of Medical Genetics Part A, Volume 200, Issue 3, Page 733-737, March 2026.ABSTRACT Hypoparathyroidism, sensorineural deafness, and renal dysplasia (HDR) syndrome is caused by pathogenic variants in the GATA3 gene located on chromosome 10p14. Here we present a 10‐year‐old girl with HDR syndrome who also has oligoarticular juvenile idiopathic arthritis (JIA).
Lauren N. Meiss +8 more
wiley +1 more source
Arthritis &Rheumatology, Volume 78, Issue 3, Page 743-751, March 2026.Objective To estimate the effect of time from symptom onset to start of biologic treatment on achieving inactive arthritis within six months in a cohort of patients with juvenile idiopathic arthritis (JIA). Methods The international UCAN CAN‐DU study prospectively enrolled patients with JIA across Canada and the Netherlands.
Jelleke B. de Jonge +102 more
wiley +1 more source