Results 241 to 250 of about 589,621 (302)

Long noncoding RNA GCH1 mediates mitophagy via the PTEN‐induced kinase 1/Parkin pathway to drive chondrocyte dysfunction and cartilage degeneration in osteoarthritis

Animal Models and Experimental Medicine, EarlyView.
The graphical abstract illustrates the role of lncRNA‐GCH1 in regulating mitophagy and its downstream effects on chondrocyte dysfunction and cartilage degradation in osteoarthritis (OA). Elevated lncRNA‐GCH1 stabilizes PINK1 protein, enhancing mitophagy and mitochondrial turnover.
Gang Zeng, Yujun Sun, Taihe Liu, Wenzhou Liu, Yanbo Chen, Jionglin Wu, Jiayuan Zheng, Weidong Song, Yue Ding   +8 more
wiley   +1 more source

Dissecting immune-mediated pathways in rheumatoid arthritis: A multivariate mediation analysis of antibodies and circulating proteins. [PDF]

Sci Rep
Niu J, Zhang P, Liu W, Sun S, Zhang Y, Sang J, Yang J, Zhang Q, Chai L.   +8 more
europepmc   +1 more source

Systematic review of the subcutaneous air pouch model using monosodium urate and calcium pyrophosphate and recommendations for studying crystal‐related arthropathies

Animal Models and Experimental Medicine, EarlyView.
Simplified schematic for generation of the subcutaneous air pouch model in the rodent. On day 0 and 4, air is injected into the subcutaneous space on the dorsal surface of the rodent to generate a cavity analogous to a synovial joint. On day 6, monosodium urate (MSU) or calcium pyrophosphate (CPP) crystals are injected into the pouch to stimulate ...
Wenu Hewage, Josif Vidimce, Ryan G. Shiels, Michael Morgan, Andrew C. Bulmer   +4 more
wiley   +1 more source

Serum biochemical marker of synovial tissue turnover, C1M, predicts radiological progression in early rheumatoid arthritis. [PDF]

RMD Open
Garnero P, Falkenløve Madsen S, Eymard F, Sellam J, Chapurlat R, Bay-Jensen AC.   +5 more
europepmc   +1 more source

New Horizons for Multiple Sclerosis Therapy: 2025 and Beyond

Annals of Neurology, EarlyView.
The advances achieved against multiple sclerosis (MS) represent one of the great success stories of modern molecular medicine. The development of therapies with increasing selectivity and safety, guided by gains in understanding the fundamental immunology, neurobiology, genetics, and triggers of this disease, have broadened the traditional focus on ...
Joseph J. Sabatino Jr., Bruce A. C. Cree, Stephen L. Hauser   +2 more
wiley   +1 more source

Association between Rheumatoid Arthritis and the Incidence of IgA Nephropathy.

Am J Nephrol
Azegami T, Kaneko H, Okada A, Suzuki Y, Fujiu K, Nakayama T, Takeda N, Morita H, Takeda N, Fukui A, Yokoo T, Kaneko Y, Yasunaga H, Nangaku M, Hayashi K.   +14 more
europepmc   +1 more source

Potential Application of a Water‐Soluble Fullerene C60 Decorated with Diethylene Glycol in Treatment of Osteoarthritis

Advanced NanoBiomed Research, EarlyView.
A new ethoxyethanol derivative of iminofullerene, F2, is synthesized and labeled with 99mTc to produce 99mTc‐F2. In vitro, compound F2 inhibits the activation of primary mouse bone marrow‐derived macrophages stimulated with lipopolysaccharide. Moreover, 99mTc‐F2 is selectively enriched in the injured joints of mice. Inflammatory macrophages play a role
Rui He, Alyssa Costello, Yanjie Liu, Weicheng Wang, Zhichang Zhang, Quanjun Cui, Xinlin Yang   +6 more
wiley   +1 more source

Autoantibody clusters in rheumatoid arthritis are not driven by antigen specificity or isotype. [PDF]

RMD Open
van Mourik AG, Johansson L, van Wesemael TJ, Maurits MP, Kokkonen H, Rönnelid J, Knevel R, Toes REM, Rantapää-Dahlqvist S, van der Woude D.   +9 more
europepmc   +1 more source

Comorbidity in incident rheumatoid arthritis: a nationwide case-control study with bidirectional follow-up. [PDF]

Rheumatology (Oxford)
Batko B, Szeląg M, Krajewska-Włodarczyk M, Żuber Z, Orleański M, Podwójcic K, Sowiński J, Świderek M, Maluchnik M, Batko K, Śmiglewska A, Brzosko M, Stajszczyk M, Kwiatkowska B.   +13 more
europepmc   +1 more source

Association between cardiovascular-kidney-metabolic health and rheumatoid arthritis prevalence: A cross-sectional study. [PDF]

Medicine (Baltimore)
Wang J, Liu C, Ye Z, Lin H, Chen L.
europepmc   +1 more source