This study reveals that M2‐EVs mitigate periodontitis‐induced bone resorption by modulating neutrophil fate. Single‐cell RNA sequencing identified an Anxa1hi neutrophil subpopulation with pro‐reparative properties. M2‐EVs disrupt neutrophil maturation, promoting this subpopulation through key reprogramming genes (Acvrl1, Fpr2). These findings highlight
Yufei Yao+7 more
wiley +1 more source
Management of septic arthritis in adults with a hot swollen joint: British Society for Rheumatology guideline scope. [PDF]
Arumalla N+21 more
europepmc +1 more source
BACTERIOLOGIC STUDIES IN CHRONIC ARTHRITIS AND CHOREA [PDF]
John H. Richards
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Integrated single‐cell transcriptomic and metabolomic analyses reveal that MYC‐driven glycolysis activates the PI3K‐AKT‐FOXO1 pathway, disrupting Th17/Treg balance and promoting uveitis. MYC inhibition restores immune homeostasis and alleviates disease symptoms.
He Li+11 more
wiley +1 more source
Mendelian randomization analysis of gut microbiota-driven immune modulation in rheumatoid arthritis: New mechanistic insights and therapeutic targets. [PDF]
Tan H+6 more
europepmc +1 more source
A COMPARATIVE STUDY OF ANTIHY ALURONIDASE, ANTISTREPTOLYSIN “O,” ANTISTREPTOKINASE, AND STREPTOCOCCAL AGGLUTINATION TITERS IN PATIENTS WITH RHEUMATIC FEVER, ACUTE HEMOLYTIC STREPTOCOCCAL INFECTIONS, RHEUMATOID ARTHRITIS AND NON-RHEUMATOID FORMS OF ARTHRITIS 1 [PDF]
Robert W. Quinn, Sung J. Liao
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Advanced Pharmaceutical Nanotechnologies Applied for Chinese Herbal Medicines
This review offers a comprehensive overview of pharmaceutical nanotechnology strategies to address limitations associated with the complex material basis and relative mild therapeutic efficacy of Chinese herbal medicines, and summarizes the advantages of these strategies.
Jiameng Li+11 more
wiley +1 more source
Septic Arthritis After Anterior Cruciate Ligament Reconstruction: A Comparative Study of Pediatric, Adolescent, and Young Adult Populations. [PDF]
Chona D+11 more
europepmc +1 more source
Bacteroides fragilis‐derived outer membrane vesicles deliver miR‐5119 and alleviate colitis by targeting PD‐L1 to inhibit GSDMD‐mediated neutrophil extracellular trap formation. Abstract Inflammatory bowel disease (IBD) results from a breakdown in the symbiotic relationship between the intestinal commensal microflora and the mucosal immune system.
Yi Yang+11 more
wiley +1 more source