Results 321 to 330 of about 503,391 (396)

Mechanism of ITGB2 in Osteoclast Differentiation in Osteoarthritis

open access: yesCell Proliferation, EarlyView.
In osteoclast precursors, higher ITGB1 than ITGB2 expression increases ITGA2‐ITGB1 integrin. In OA, extracellular signals upregulate ITGB2 and downregulate ITGB1, enhancing ITGA2‐ITGB2 integrin. This activates Rac1 to Rac‐GTP, driving osteoclast differentiation. Hyperactive subchondral osteoclasts accelerate OA progression.
Yang Yang   +16 more
wiley   +1 more source

Medical countermeasures during public health emergencies—Does information sharing among health system coalition help?

open access: yesDecision Sciences, EarlyView.
Abstract Challenged by constrained healthcare resources, hospitals encounter barriers to accommodating patient demand during public health emergencies. Building on a comprehensive literature review of information and knowledge exchange in healthcare, disaster management, and humanitarian operations management, this study explores the influence of ...
Sukrit Pal, Anand Nair
wiley   +1 more source

It is all about value now: The data you need to collect and how to do it [PDF]

open access: yes, 2018
Bozic, Kevin J   +3 more
core   +1 more source

Post‑Marketing Surveillance of the Safety and Effectiveness of Emicizumab in Japanese Patients With Congenital Haemophilia A With Inhibitors

open access: yesHaemophilia, EarlyView.
ABSTRACT Introduction The bispecific monoclonal antibody emicizumab was approved for prophylactic treatment of congenital haemophilia A (HA) in Japan in 2018. Aim To monitor long‐term safety and effectiveness of emicizumab, including appropriate concomitant use of bypassing agents (BPAs), in Japanese patients with congenital HA with inhibitors who ...
Midori Shima   +7 more
wiley   +1 more source

How effective is mHealth-supported home-based post-knee arthroplasty rehabilitation in improving knee function and continuum of care: protocol of an open label randomised controlled trial from India. [PDF]

open access: yesBMJ Open
Girotra S   +15 more
europepmc   +1 more source

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