Results 231 to 240 of about 42,934,457 (315)

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

Imaging Diagnosis-Sonographic Features of Bilateral Renal Lymphangiectasia in an Azotemic Dog. [PDF]

Vet Radiol Ultrasound
Wang Y, Mai W, Dourmashkin L, Leopardi V, Amerman H.   +4 more
europepmc   +1 more source

Abstract of Forthcoming Article [PDF]

, 2016
Chrisman, Rodney
core   +4 more sources

ARTICLE XV A CASE IN WHICH POUR INCHES OF THE ENTIRE DIAMETER OF THE SHAFT OF THE PEMUE WERE LOST, BY NECROSIS, WITH COMPLETE RECOVERY [PDF]

, 1884
John C. Ferguson
openalex   +1 more source

The roles and applications of extracellular vesicles in cancer

Molecular Oncology, EarlyView.
Extracellular vesicles (EVs) are minute versions of cells limited by a lipid bilayer containing cytoplasm from the cell that releases them, but without a nucleus and thus unable to self‐reproduce. EVs contain multiple molecules (proteins, lipids, glycans, and nucleic acids) they can induce complex responses in cells.
Clotilde Théry, Daniel Louvard
wiley   +1 more source

Correction: Student-centered factors influencing inclusion in biomedical majors among first-year undergraduate students. [PDF]

PLoS One
PLOS One Staff.
europepmc   +1 more source

DISCUSSION OF AN ARTICLE BY ELLIS LOVEJOY, ENTITLED, “NOTES ON FIRE CLAYS OF THE NORTHERN APPALACHIAN COAL BASIN,” IN THE MAY NUMBER OF THE JOURNAL OF THE AMERICAN CERAMIC SOCIETY¹ [PDF]

, 1919
George H. Ashley
openalex   +1 more source

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan, Elizabeth Thomas, Mehari M. Weldemariam, Puranik Purushottamachar, Weiliang Huang, Maureen A. Kane, Yuji Zhang, Nicholas Ambulos, Bi‐Dar Wang, David Weber, Vincent C. O. Njar   +10 more
wiley   +1 more source

The Role of Health Psychology in Surgical Prehabilitation: Insights From REST, a Preoperative Sleep Intervention for Total Knee Replacement Patients. [PDF]

Musculoskeletal Care
Whale K, Johnson E, Gooberman-Hill R.
europepmc   +1 more source

ARTICLE XIII. ON VACCINATION [PDF]

, 1880
Walter F. Atlee
openalex   +1 more source