Results 241 to 250 of about 48,303,877 (349)

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

Digital Long Covid Communities-Shaping Diagnoses, Treatment Strategies and Modes of Expertise. [PDF]

Health Expect
Almqvist-Ingersoll P.
europepmc   +1 more source

ARTICLE II. Ox SIMULTANEOUS LIGATION OF THE COMMON CAROTID AND OF THE SUBCLAVIAN IN ITS THIRD PORTION IN THE TREATMENT OF SUPPOSED ANEU-RISM OF THE ARTERIAL INNOMINATA, WITH A CASE [PDF]

, 1880
Lewis A. Stimson
openalex   +1 more source

The roles and applications of extracellular vesicles in cancer

Molecular Oncology, EarlyView.
Extracellular vesicles (EVs) are minute versions of cells limited by a lipid bilayer containing cytoplasm from the cell that releases them, but without a nucleus and thus unable to self‐reproduce. EVs contain multiple molecules (proteins, lipids, glycans, and nucleic acids) they can induce complex responses in cells.
Clotilde Théry, Daniel Louvard
wiley   +1 more source

Plasma Trough Concentrations of Beta-Lactam Antibiotics in the Early Phase of Septic Shock. [PDF]

Acta Anaesthesiol Scand
Hägglund M, Brink M, Martin US, Bremell D, Svensson CJ.   +4 more
europepmc   +1 more source

THE RUSSIAN ARCTIC SEA LANE: ENDEAVOUR AND ACHIEVEMENT: Review Article of "The Northern Sea Route," by Terence Armstrong

, 1952
C.J. Webster
openalex   +2 more sources

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan, Elizabeth Thomas, Mehari M. Weldemariam, Puranik Purushottamachar, Weiliang Huang, Maureen A. Kane, Yuji Zhang, Nicholas Ambulos, Bi‐Dar Wang, David Weber, Vincent C. O. Njar   +10 more
wiley   +1 more source

In Memorial - Dorothy Erstling Cukier [PDF]

, 2023
Editor, Lead Article
core   +1 more source

Transforming Patient-Reported Outcome Measurement With Digital Health Technology. [PDF]

J Eval Clin Pract
Jackman L, Kamran R.
europepmc   +1 more source

Article on Dr. Moore

, 1956
NULL AUTHOR_ID
openalex   +1 more source